A drug container closure for mounting on an open-topped drug container to form a ready-to-use drug reconstitution assemblage for use with a needleless syringe. The drug container closure includes a drug container stopper for sealing the drug container and a fluid transfer member with an integral needleless syringe connector and a puncturing cannula. The fluid transfer member is manually disposed along a diametric inverted L-shaped track pair from an initial non-puncturing position to a puncturing position. The inverted L-shaped track pair includes one-way snap members to prevent a user returning the fluid transfer member to an earlier position and indicating progress of the user activation.

Liquid drug transfer devices employing manual rotation of a drug vial adapter with respect to a liquid container adapter for dual flow communication step actuation for establishing flow communication between a liquid container containing liquid contents and an initially intact, namely, non-punctured, drug vial. Manual rotation compacts a liquid drug transfer device along a longitudinal device axis for urging a puncturing tip through a drug vial stopper during a drug vial flow communication step for flow communication with a drug vial interior. Manual rotation also executes a liquid container flow communication step for flow communication with a liquid container, therefore establishing flow communication between a drug vial and a liquid container.

A needle-less vial assembly that includes a substance transfer assembly configured to telescopically engage with a vial neck of a vial. A first portion of the substance transfer assembly is configured to sealingly engage with an interior wall of the vial neck, where the first portion includes a first inlet configured to receive a substance from the vial. A second portion of the substance transfer assembly is configured to matingly engage with a syringe, and includes an outlet configured to dispense the substance to the syringe. A channel is defined through the first portion and the second portion, thereby enabling fluid communication of the substance from the vial to the syringe via the first inlet and the outlet.

An integrated medicine mixing interface comprising a medicine mixing mouth (1), hard double interfaces (2) and a medicine feed needle (3). The hard double interfaces (2) comprise a base (21), a medicine mixing interface (22) and an infusion interface (23). The medicine mixing mouth (1) and the medicine mixing interface (22) are integrated. When using the integrated medicine mixing interface, it is only necessary to weld the base (21) to the bag body of a soft infusion bag (11) and integrate the medicine mixing mouth (1) with the medicine mixing interface on the hard double interfaces (2) without adopting a hose connection and an easily folding handle, which not only reduces hose installation location, but also avoids welding leakage brought about by hose welding defects. Moreover, the structure is simple and the costs are low.

This CIP, Continuation-in-part, presents constructive details of the material contained in the original document BR 10 2016 016091-0 and not specified until then, and the valve (3) can also be used in transfers, dilution and drip chamber and medicine bottles, vaccines and related, the valve (3) has five basic components: conical base (4), which receives in its interior the assembly of the second component, which is the conical movable part (7); the conical base (4) which receives in its core (16) the assembly of the third component which is a smaller diameter o-ring sealing ring (13); on the other hand, the conical movable part (7) receives in its lower groove (14) the assembly of the fourth component, which is a larger diameter o-ring sealing ring (12); the conical base (4) receives the assembly of the fifth component which is the cap (10), which protects the thread in the luer-lock pattern (8); the cover (10) prevents the separation of the conical movable part (7) in relation to the conical base (4); the movable conical part (7) has a surface (22) with an angulation (X), equal to that verified on the inner surface (27) of the conical base (4); the constructive variation of the valve (3a) is fixed to the mouthpiece (6a) of the bottle (F) through its conical base (4), this adjusted to the diameter of the bottle, keeping the valve system unchanged; in addition, the cover (10) of the valve (3a) presents a constructive variation (not shown) formed by a cylindrical body, internally threaded, provided with a lower ring connected to the cover body through a plurality of breaking points, welding points plastic or shrink.

A method of powderizing a dry cake pharmaceutical drug product for injection within a vial may include securing a vial containing a dry cake pharmaceutical drug product for injection to a shaker device and powderizing the dry cake pharmaceutical drug product within the vial by shaking the vial with the shaker device operated at between about 100 to about 5000 cycles per minute for between about 10 minutes and about 1 hour.

A fluid connector for selectively establishing fluid communication between a first medical container and a second medical container is provided. The fluid connector includes an adapter configured to removably attach to the first container. The adapter includes an access port and a cap. The connector further includes an outer sleeve connected to the adapter and a tubular body retained at least partially within the outer sleeve. The body has a proximal end connected to the adapter and a distal end connected to the second container. The fluid connector is transitionable from a first position in which the first container and the second container are in fluid isolation to a second position in which the first container and the second container are in fluid communication. At least a portion of the cap of the adapter is retained within the outer sleeve.

A package that is configured to store and dispense fluids. The package includes a container and a dosing dispenser for closing an opening to the container. The dosing dispenser includes a body portion having a syringe receiver that is configured to receive a syringe to remove fluid from the container.

Kits and methods provide for the isolation of white blood cells from bodily fluids. In one exemplary aspect, a method for isolating white blood cells from blood includes the act of adding a blood sample to a separation tube having a distal end, a proximal end, and a valve located proximate said proximal end, said valve being configured to transition between at least first, second, and third positions. The method also includes the act of removably attaching a cap to the distal end, centrifuging the separation tube with the valve in the first position, removing the cap at the distal end of the separation tube and removably attaching a first syringe to the proximal end, switching the valve to the second position and withdrawing, via the first syringe, a red blood cell sediment. The method also includes the act of switching the valve to the first position and removing the first syringe, adding a small volume of buffer to the separation tube, removably attaching a cap to the distal end and centrifuging the separation tube and removing the cap at the distal end of the separation tube and removably attaching a second syringe to the proximal end. Additional acts include switching the valve to the second position, withdrawing the remaining red blood cell sediment via the second syringe and switching the valve to the first position and removing the second syringe.

A fluid transfer apparatus is illustrated and described. The fluid transfer apparatus includes a fluid inlet, a fluid outlet and a fluid transfer device. The fluid inlet is associated with a fluid receptacle receiving portion, and the fluid receptacle receiving portion is configured to receive and engage at least a portion of a fluid receptacle. The fluid transfer apparatus is configurable between a first isolation state, in which the fluid transfer device is isolated from the fluid receptacle, such that the fluid container is fluidically isolated from the fluid inlet, to a second coupled state, in which the fluid transfer device is engaged with the fluid receptacle, such that the fluid receptacle is in fluid communication with the fluid inlet.