Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, and which composition is effective in treating a disorder of the nail or nail bed.

The present invention relates to a compound represented by the following formula (I):

A[B—(C).sub.v].sub.w  (I), wherein A is a photoprotective moiety, B is a linker, C is a functional group, v is an integer from 1 to 2000, and w is an integer from 1 to 6. It also relates to a composition comprising the same and, more particularly, to a cosmetic or a sunscreen composition. It also relates to the use of such compounds in cosmetic and therapeutic applications. The invention also relates to the use of such compounds for reducing photodegradation and/or photoinstability of pharmaceuticals and cosmetics. The invention further relates to a material comprising a support and such a compound adhered to said support.

The present invention relates to sunscreen or daily care compositions comprising (i) an ultraviolet absorber water-dispersed composition comprising (a) micronized methylene bis-benzotriazolyl tetramethylbutylphenol, and (b) at least one polyglycerol monoalkyl ester; and (ii) at least one oil soluble UVA filter.

Disclosed are cosmetic or pharmaceutical composition comprising a UV filter combination of (a) an aqueous dispersion of 5,6,5′,6′-tetraphenyl-3,3′-(1,4-Phenylene)bis(1,2,4-Triazine) corresponding to the formula ##STR00001## in particulate form; and (b) the UV filters selected from (b.sub.1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b.sub.2) Butyl Methoxydibenzoylmethane; (b.sub.3) Diethylhexyl Butamido Triazone; (b.sub.4) Ethylhexyl Triazone; (b.sub.5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b.sub.6) Ethyhexyl Methoxycinnamate; (b.sub.7) Ethylhexyl Salicylate; (b.sub.8) Homosalate; (b.sub.9) Octocrylene; (b.sub.10) Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b.sub.11) Phenylbenzimidazole Sulfonic Acid; (b.sub.12) Titanium Dioxide; (b.sub.13) Tris-Biphenyl Triazine; and (b.sub.14) (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone; (b.sub.15) BBDAPT; Benzoic acid, 4,4′-[[6-[[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1 disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester; (b.sub.16) benzylidene malonates; and (b.sub.17) merocyanine derivatives; (b.sub.18) Bis(butylbenzoate) diaminotriazine aminopropylsiloxane; (b.sub.19) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) encapsulated in a polymer matrix; (b.sub.20) 2-(2H-Benzotriazol-2-yl)-6-[(2-ethylhexyloxy)methyl]-4-methylphenol; and (b.sub.21) 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-methylphenyl ester.

The present invention relates to a sunscreen formulation comprising at least one of the UV filters (A) selected from (a) triazine derivatives; (b) cinnamic acid derivatives; (c) bis-resorcinyl triazines; (f) benzimidazole derivatives; (i.sub.5) 4-Methylbenzylidene Camphor; (h) benzoyl piperazine derivatives; (j) benzoxazole derivatives; (k) diarylbutadiene derivatives; (I) phenyl benzotriazole derivatives; (n) benzylidene malonates; (o.sub.3) TEA-Salicylate; (r) imidazoline derivatives; (u) inorganic UV filters selected from metal oxides; (v) naphthalates; and (w) merocyanine derivatives; and optionally comprising at least one of the UV filters (B) selected from (d) aminobenzophenone derivatives; (e) dibenzoylmethane derivatives; (g) β,β-Diphenylacrylate derivatives; (i.sub.5) camphor derivatives different from; (o.sub.3) salicylate derivatives different from; (p) anthranilate derivatives; and (s) benzalmalonate derivatives; wherein the ratio R of the effective irradiance for previtamin D.sub.3 formation E.sub.pvd to the effective irradiance for erythema formation E.sub.er on the skin is at least 1.8, for increasing the transmittance of UV radiation on human skin for the production of cholecalciferol (previtamin D.sub.3) and simultaneously for the use in a method for protecting the human skin against UV radiation when exposed to the sun, which method comprises applying said sunscreen formulation to the skin.

Sunscreen composition including a combination of a linear ultraviolet radiation absorbing polyether that includes a covalently bound UV-chromophore, and at least one non-polymeric UV-screening compounds.

Disclosed herein are methods of making and using sunscreen compositions comprising at least one UV absorbing conjugate compound. The present disclosure comprises compositions comprising at least one UV absorbing conjugate compound that reflects and/or absorbs UV radiation, such as UV-A, UV-B and/or both UV-A and UV-B, that are not absorbed by, transmitted across and/or transported from the surface of the subjects body to the interior of the body or circulatory system of the subjects body.

This invention provides an inhibitor of multidrug resistance-associated proteins with 12 transmembrane domains containing, as an active ingredient, a compound for treatment of hyperuricemia or a salt thereof. In an embodiment, the compound is represented by Formula I

##STR00001##

wherein R.sup.1 represents a halogen atom, a nitro group (—NO.sub.2), a cyano group (—CN), a formyl group (—CHO), or a trifluoromethyl group (—CF.sub.3), R.sup.2 represents a hydrogen atom or an alkoxy group having C.sub.1-10 linear or branched alkyl group, X represents a carboxyl group (—CO.sub.2H), a carbamoyl group (—CONH.sub.2), or an alkoxycarbonyl group having C.sub.1-5 linear or branched alkoxy group, and Y represents a hydrogen atom or a C.sub.1-4 linear or branched alkyl group. In an embodiment, the multidrug resistance-associated protein with 12 transmembrane domains is ABCC11. In particular, the inhibitor of the present invention can be used in a pharmaceutical or cosmetic composition for the prevention or treatment of axillary osmidrosis.

Provided are preparation of a PCM microcapsule in the form of a core-shell having an excellent heat absorption function by using a temperature-controllable phase change material (PCM) as a core material and a biodegradable polymer material as a shell material, and a cooling cosmetic composition for external skin capable of exhibiting a prevention effect of thermal aging using the same. The core-shell PCM microcapsule having an automatic temperature control function according to the present invention is prepared by dissolving a shell material and a single or mixed PCM in a solvent to produce an oil phase polymer solution, dissolving an aqueous polymer to produce an external continuous phase, emulsifying the oil phase polymer solution and the external continuous phase, and removing the external continuous phase and the solvent and carrying out drying.

A cosmetic including at least one cyclic silicone represented by formula (1), and having a boiling point of 205 to 255° C. and a viscosity of less than 5 mm.sup.2/s (25° C.). This cosmetic has a light touch, a good spread, and excellent water repellency, forms a uniform cosmetic film, can achieve a feeling of use without a strong oily feeling, and has stability over time and cosmetic persistence when a variety of oil such as a silicone, hydrocarbon oil, and ester, an organic ultraviolet absorber, or an oily component being solid at 25° C. is mixed. ##STR00001## (Wherein R.sup.1 is a monovalent hydrocarbon group having 2 or 3 carbon atoms, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are each independently a monovalent hydrocarbon group having 1 to 3 carbon atoms, “a” is a positive number satisfying 0<a<4, and “b” and “c” are each independently a number of 0 to 3, provided that (a+b+c)≤4.)