Various implementations include a mixing vial for use in a cartridge syringe. The mixing vial includes a vessel, a stopper, and a dislodgeable plug. The stopper includes an open first end, a closed second end, and a stopper side wall. A hollow interior chamber is defined by the stopper side wall and the closed second end. The stopper is positioned in a sealing relationship with an inner surface of the vessel. An outer surface of the stopper side wall includes two ribs extending radially outwardly from the stopper side wall. Each of the two ribs is axially spaced apart from each other. An inner surface of the stopper side wall defines an annular groove located axially between the two ribs. The dislodgeable plug is disposed within the hollow interior chamber of the stopper such that an edge of the dislodgeable plug is disposed within the groove of the stopper.

An injection system includes a syringe body defining a proximal opening at a proximal end thereof and a distal needle interface at a distal end thereof. The system also includes proximal and distal stopper members disposed in the syringe body, forming respective proximal and distal drug chambers. The system further includes a plunger member configured to be manually manipulated to insert the proximal stopper member relative to the syringe body. Moreover, the system includes a fluid conveying assembly including a penetrating member configured to penetrate the distal stopper member to fluidly couple the proximal and distal drug chambers, a distal exit tube, and a transfer member disposed at least partially around a portion of the penetrating member and defining a fluid passage. A distal end of the penetrating member is disposed in the distal exit tube.

The present disclosure relates to a container (10) for at least a first injectable medicament (60), the container comprising:an elongated body (11) having a tubular-shaped sidewall (12) extending along a longitudinal axis (z) and having a distal end (13), wherein the elongated body (11) comprises a hollow space (15) with a needle receiving subsection (17) adjacent to the distal end (13),an outlet (40) at the distal end (13) of the body (11),a piston (20) arranged inside the elongated body (11), sealingly engaged with the sidewall (12) and slidable along the longitudinal axis (z) relative to the sidewall (12),a membrane (30) arranged inside the elongated body (11) sealingly engaged with the sidewall (12) and being at least one of slidable and deformable along the longitudinal axis (z) relative to the sidewall (12),a first cavity (16) confined by the sidewall (12), the outlet (40) and the membrane (30), wherein the first injectable medicament (60) is located in the first cavity (16),a second cavity (18) confined by the sidewall (12), the piston (20) and the membrane (30), wherein the piston (20) and the membrane (30) are separated from each other by a distance along the longitudinal axis (z),wherein the outlet (40) is configured to receive or to hold a needle (50) extending from the distal end (13) into the needle receiving subsection (17), andwherein in an initial configuration, the membrane (30) is located outside the needle receiving subsection (17) and wherein the membrane (30) is displaceable or deformable relative to the sidewall (12) to such an extent that at least a portion (31) of the membrane (30) enters the needle receiving subsection (17).

The disclosure relates to a needle assembly adapted to couple with a medicament delivery device including a needle having a proximal tip and a distal tip, a needle hub coupled to the needle, a body adapted to engage the needle hub, a removable needle cap adapted to cover the distal tip, and a removable sealing element. The sealing element is adapted to seal an open proximal end of a compartment of the body, including the proximal tip, in such a manner that the proximal tip is housed in a sealed environment before use of the needle. The disclosure further relates to a medicament delivery device including such a needle assembly.

A method for buffering anesthetic.

An injection device (100) including a tubular body (3) within which a cartridge is inserted (10) equipped with a bottom (14) and a back chamber (8) containing one first substance (SI). The device (100) also has a front chamber (9) containing one second substance (S2) intended to be mixed inside the tubular body (3) with the first substance (SI) to reconstitute the injectable substance (S). The device (100) is characterized in that the cartridge (10) has a flexible body (13) suitable for tearing as a result of the increase of pressure inside the cartridge (10) in order to put in communication the back chamber (8) with the front chamber (9) and to allow the reconstitution of the injectable solution (S).

A drug delivery housing device includes a first housing component comprising a first connecting end, and a second housing component comprising a second connecting end. An insert is provided on the first or second connecting end, and a receptacle is provided on the other one of the first and second connecting ends. The insert is insertable into the receptacle for mutually fastening the first and second housing components. A threaded connection mutually connects the first and second connecting ends and includes a helical thread on the insert and a helical counter thread complementary shaped to the helical thread and provided in the receptacle. A rotation lock is configured to impede screwing and/or unscrewing of the first and second housing components. The rotation lock includes a locking structure on the first housing component and a counter locking structure complementary shaped to the locking structure and provided on the second housing component.

The invention provides in one aspect a drug delivery device comprising a drug container assembly containing a drug, and a plunger positioned within the container assembly, the drug container assembly having an outlet for dispensing the drug, wherein, in an initial position, the outlet is sealed; a drive mechanism comprising a first stored energy source operable to apply pressure on the plunger or the drug container to pressurise the drug, and a first release mechanism operable to unseal the outlet after the drug has been pressurised. In another aspect, there is provided a drug delivery device comprising a housing, including an external housing portion configured to be held in use and a drug containing portion containing a drug, a needle assembly comprising a needle fixed to a needle hub, the needle hub configured to move relative to the drug containing portion from an initial position within the housing to an insertion position in which the needle extends beyond the housing, a first stored energy source configured to move the needle hub from the initial position to the insertion position, and a plunger within the housing and configured to move relative to the drug containing portion to eject the drug through the needle when the needle is in the insertion position.

A medicament delivery device (100) for the delivery of medicament from a container (12) through a cannula (16). The device comprises a chassis (300), a carriage (200), and an insertion spring (70) for biasing the carriage (200) for movement in an insertion direction with respect to the chassis (300) from a starting position in which the cannula (16) is shrouded to an insertion position in which the cannula (16) is extended. A drive mechanism (400) is provided for driving the container's stopper (22) to expel medicament. The drive mechanism (400) is carried by the carriage (200) and comprises a movable drive member (404), a drive means (40) for applying a driving force to the drive member (404), and force transmission means (406) for transmitting the driving force to the stopper (22). The drive means (40) is arranged around or alongside at least part of the force transmission means (406).

The present invention relates to a housing of a drug delivery device comprising a cylindrically shaped body (12) to accommodate a drive mechanism (13) and comprising a cartridge holder (14) to accommodate a cartridge (16) containing a dispensable medicament, the housing further comprising a connector assembly (20) to releasably interconnect body (12) and cartridge holder (14), the connector assembly (20) comprising: a tangentially extending recessed structure (30) with a tangential opening (31) to receive a radially extending pin (26), wherein the recessed structure (30) is fastened to one of body (12) and cartridge holder (14) and wherein the pin (26) is fastened to the other one of body (12) and cartridge holder (14), a release member (40) having a retaining portion (42) to cover the opening (31) in a locking configuration (60), wherein the release member (40) is displaceable in tangential direction (3) against a restoring force away from the recessed structure (30) into a release configuration (62), in which the opening (31) is uncovered to tangentially remove the pin (26) therefrom.