Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

An electrode for electrical stimulation of tissue and administration of substances to the tissue includes a first conductive plate and a second conductive plate surrounding the first conductive plate. The first conductive plate and the second conductive plate are separated from each other. An activation signal is applied to the first conductive plate to generate an electric field inducing a current in the tissue and applying an electric potential to the second conductive plate to obtain an electric potential differential with respect to the first conductive plate. The electric potential of the second conductive plate forces the current induced by the first conductive material plate to penetrate the surface of the tissue in contact with the conductive plates and prevents the induced current from flowing on the surface of the tissue.

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Various systems and methods provide iontophoretic delivery of anesthesia at a patient's tympanic membrane. Some implementations provide channel switching enabling a single current sink to pull current through two electrodes in an alternating fashion based on clock pulses. The iontophoretic delivery of anesthesia may be driven by an AC modulated current. Some implementations provide for continuous flow of fresh iontophoresis fluid to the ear canal during iontophoresis. The fluid flows from a source reservoir into the cavity between the tympanic membrane and a plug, and then drains out of the cavity to a reservoir. An iontophoresis system may also detect capacitance between an anode electrode and an auxiliary electrode in a patient's ear canal, watching for reduced capacitance to indicate presence of a bubble in the iontophoresis fluid.

An adhesive polymer matrix for the delivery of an active principle via iontophoresis. The matrix having a first face intended to be applied onto skin and a second face intended to cooperate with electrodes. The matrix comprises electrically conductive zones and at least one electrically insulating zone, each conductive zone being insulated from another conductive zone by an insulating zone. The techniques involve the use of an electric current in order to facilitate the transdermal diffusion of active substances, and relates more particularly to an iontophoresis device.

A drug delivery device (100) includes a base (102) having a first region (104) with a drug delivery assembly (106) associated therewith. The drug delivery device also includes an antenna (112) disposed in the first region to radiate an electromagnetic field, the base defining a plane (114) and the antenna disposed in the plane of the base, and an electromagnetic field generator (116) selectively coupled to the antenna.

A benefit agent delivery system whereby benefit agents can be delivered on demand and/or a variety of different benefit agents at different concentrations can be delivered from the same system. The benefit agent delivery system includes a microcell layer comprising a plurality of microcells, wherein the microcells are filled with a carrier and a benefit agent. The microcells include an opening, wherein the opening is spanned by a sealing layer comprising a polymer and metallic material. Application of an electric field across the microcell layer and the sealing layer results in the migration of the metallic material from the sealing layer and the creation of a porous sealing layer, allowing the benefit agent to be released from the benefit agent delivery system.

A skin care device according to an embodiment includes a main body and a head part connected to the main body, wherein the head part includes a housing in which an upper portion thereof is open, and including an accommodation space therein, an electrode part disposed in the housing, a plurality of light emitting elements disposed in the housing and spaced apart from the electrode part, and a cover part for shielding of the open upper region of the housing, wherein the cover part includes a hole corresponding to the electrode part, a part of the electrode part protrudes from an upper surface of the cover part via the hole, and an upper surface of the electrode part facing a skin of a user includes a convex curved surface toward the skin.

An iontophoresis device may include a flexible support layer, an electrode layer, having at least two electrically isolated electrodes, fixed to the support layer. A return electrode is separated from the electrode layer and the flexible support layer. A control module is detachably connected to the electrode layer and to the return electrode. The control module is configured to provide a variable current source or a variable voltage source only to a selected proper subset of the at least two electrically isolated electrodes while not providing the variable current source to other electrodes of the at least two electrically isolated electrodes.

A patch for a therapeutic electrical stimulation device includes a shoe connected to the first side of the patch, the shoe including a body extending in a longitudinal direction from a first end to a second end, and having first and second surfaces, the first end of the shoe defining at least two ports, and the first surface of the shoe defining a connection member. The patch also includes at least one conductor positioned in the ports of the first end of the shoe. The shoe is configured for sliding insertion into a receptacle defined by a controller so that the conductor is connected to the controller to deliver electrical current from the controller, through the conductor, and to the electrodes, and the connection member is at least partially captured by a detent defined by the controller in the receptacle to retain the shoe within the receptacle.