The disclosure relates to methods of treating or reducing ocular pain in a subject. The method includes stimulating nasal tissue in a subject in need of treatment. Optionally, the method can be performed using a stimulator probe having first and second nasal insertion prongs having respective electrodes that can be positioned adjacent to a septum of the subject. The stimulator probe can be connected to a stimulator body having a control subsystem to control an electrical stimulus to be delivered to the subject via the stimulator probe. Optionally, the subject does not have low tear volume.

Electrical stimulation devices and associated systems and methods are disclosed herein. In some embodiments, the electrical stimulation device comprises an elongated member configured to be orally or nasally inserted into a patient's pharynx. The device may further include a conductive element carried by a distal portion of the elongated member and configured to deliver stimulation energy to nearby tissue. The device can include a cover configured to move relative to the conductive elements to selectively cover or expose the conductive elements.

Electrical stimulation devices and associated systems and methods are disclosed herein. In some embodiments, the electrical stimulation device comprises an elongated member configured to be orally or nasally inserted into a patient's pharynx. The device may further include a conductive element carried by a distal portion of the elongated member and configured to deliver stimulation energy to nearby tissue to treat one or more of gastric motility, sleep apnea, and speech disorders.

Provided herein is a system comprising (1) a microelectrode array (MEA) component comprising an integrated multiplexed (MUX) logic circuit; and (2) a microprocessor, e.g., MOSFET, such as a CMOS, wherein the MEA is in electrical communication with the microprocessor such that signals produced by the microelectrodes are transmitted to the processor through the MUX. The use of a MUX reduces the number of outputs used to communicate signals from multiple microelectrodes to the microprocessor. The two components are removably engageable with each other such that after one or more uses, the engaged MEA can be removed and replaced with a new MEA, without the necessity of disposing the microprocessor.

The invention generally relates to systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition.

An apparatus for performing bioelectric stimulation, the apparatus comprising: a stimulation unit; a measurement unit comprising an amplifier; first and second stimulation electrodes operable to apply electrical signals to tissue of a patient; first and second measurement electrodes operable to receive first and second measurement signals from the tissue of the patient; wherein the stimulation unit is configured to deliver a first stimulation signal to the first stimulation electrode and a second stimulation signal to the second stimulation electrode; wherein the first signal and the second signal are mirrored about a biasing voltage, the biasing voltage set in dependence of the dynamic range of the amplifier.

Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

An implantable neurostimulator includes a lead comprising a plurality of electrodes at a distal end, and an implant body including electronics for controlling operation of the electrodes. An electrical connector establishes an electrical connection between the electronics and the electrodes. The implant body includes a first portion of the electrical connector, and the proximal end of the lead includes a second portion of the electrical connector. The first and second portions of the electrical connector are connectable to establish the electrical connection between the electronics and the electrodes. The lead is configured for initial implantation in the patient and the implant body is configured for subsequent implantation in the patient. The electrical connector is configured so that the connection of the first and second portions can be performed with the implant body and the lead positioned at a surgical site in the patient.

The present invention relates to a system and method, in which a distal end of an electrode is implanted in an organ, such as a pituitary gland, for intermittent electrical stimulation thereof and a proximal end of the electrode is provided with a connection plug, a distal end of which can be attached to a bone adjacent the organ, such an anterior wall of the sphenoid sinus/vomer, and a proximal end of which can be reversibly connected electrically to a wire that is connected electrically to a source of electrical stimulation for the organ.

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.