A system and methods for performing neurophysiologic assessments during surgery, such as assessing the health of the spinal cord via at least one of MEP and SSEP monitoring and assessing bone integrity, nerve proximity, neuromuscular pathway, and nerve pathology during spine surgery.

A container, a toothbrush, or a device including at least one sacrificial electrode. In one aspect, the container may include a body adapted to contain an oral care solution and a cap selectively removable from the body. The cap may include a cavity configured to contain a fluid, a first electrode comprising a sacrificial metal, a second electrode spaced from the first electrode, and an electrical connection electrically connecting the first electrode and the second electrode to a power source. Activation of the power source may generate an electric field between the first and second electrodes, thereby causing the sacrificial metal of the first electrode to release ions into the fluid in the cavity of the cap.

A device for electrical stimulation of one or more components of the periodontal complex and surrounding tissue of a tooth, for uses such as reducing orthodontic pain and encouraging tooth movement, has electrodes of a rigid, electrically conductive material in a fixed spatial relationship configured for application to oral mucosa and attached gingiva adjacent to, and along a periodontal ligament of, a root structure of a single tooth. An electrical circuit is configured for electrical connection to the at least two electrodes. The electrical circuit has an output providing a subsensory electrical stimulus comprising a waveform in accordance with predetermined stimulation parameters. After the electrodes are applied to the oral mucosa and attached gingiva adjacent to, and along the periodontal ligament of, a root structure of the tooth, a switch, when activated, activates the electrical circuit to output the electrical stimulus through the at least two electrodes.

An intraoral device includes a mouthpiece for receiving a dentition of a user. The intraoral appliance further includes an oxygen sensor and an infrared radiation emitter. The oxygen sensor may include a photoplethysmography sensor. The intraoral device may further include a thermoelectric power source to supply power to the infrared radiation emitter and the photoplethysmography sensor.

The present invention relates to electroporation (EP) devices that are able to generate an electroporation causing electrical field at the mucosal! layer, and preferably in a tolerable manner. Further, it includes the generation of a protective immune response, cellular and/or humoral, using the oral EP device along with a genetic construct that encodes an immunogenic sequence.

An electrical discharge irrigation device includes a power source to produce power of a first voltage, a circuit coupled to the power source to convert the power of the first voltage to power of a second voltage where the second voltage is higher than the first voltage, a trigger to activate the circuit, an igniter coupled to the circuit to produce a spike, an electrical charge storage component coupled to the igniter the electrical charge storage component becoming conductive and storing an electrical charge after receiving the spike, and an output tip. The output tip includes an electrode and insulating material as an outer layer.

An oral care device may include: a body including a head; a plurality of teeth cleaning elements extending from the head; a first electrode on the head; a second electrode on the head and spaced apart from the first electrode, wherein at least one of the first and second electrodes is a sacrificial electrode; a power source; and a controller configured to operably couple the power source to the first and second electrodes to create an electric potential between the first and second electrodes so that ions are released from the sacrificial electrode during a brushing session; wherein the controller is configured to change a magnitude of the electric potential the brushing session ends.

Mandibular repositioning devices have a maxillary piece that has a tooth covering with a driver flange protruding laterally outward on a right side proximate a backmost teeth mold and/or on a left side proximate the backmost teeth mold and have a mandibular piece that has a tooth covering with a protrusive flange extending cranially therefrom. Each driver flange has an anterior side with a convex curvature and each protrusive flange has a posterior side with a concave-to-convex curvature from its base toward its most cranial point. The convex portion of the concave-to convex curvature is positioned to engage the convex curvature of the driver flange in a rest position. Downward movement of the mandibular piece moves the convex portion of the posterior side of the protrusive flange along the convex curvature of the driver flange, thereby moving a user's mandible forward.

Mandibular lingual repositioning devices include a mandibular piece having a first teeth covering and a housing proximate a left molar portion and a right molar portion that each have a first drive and a protrusive flange extending cranially and a stimulator protrusion extending toward the tongue each extend from the housing, and include a maxillary piece having a second teeth covering and a housing proximate each of a left molar portion and a right molar portion that each have a second driver. Each housing encloses a power source electrically connected to a motor and to an on-board circuit board, and has its respective driver operatively connected to a respective motor. Each housing of the mandibular piece also has an electrode of a stimulator electrically connected to its power source. Each first driver is operatively engaged with the maxillary piece and each second driver is operatively engaged with a protrusive flange.

Mandibular repositioning devices have a mandibular piece having a first teeth covering and having a housing proximate each of a left molar portion and a right molar portion, a protrusive flange extending cranially from each housing, and a maxillary piece having a second teeth covering and having a housing proximate each of a left molar portion and a right molar portion. Each housing encloses a power source electrically connected an on-board circuit board and the housings of the maxillary piece further have the power source electrically connected to a motor operatively connected to a drive for anterior and posterior movements of the mandibular piece. The maxillary piece sits on the mandibular piece with the driver operatively engaged with the protrusive flange. The protrusive flange has a concavely-shaped anterior surface mated to a convexly-shaped head of the driver shaped to match the concavely-shaped anterior surface of the protrusive flange.