The present invention relates to an electrode assembly system for treatment of internal organ oedema by electro-osmosis and/or electrophoresis by delivering an electric field, the system comprising a first electrode, a second electrode, and a control unit, wherein the first electrode and second electrode are electrically connected to the control unit, the control unit being adapted to charge the first electrode negatively and the second electrode positively, and to directly control a strength of an electric field induced by the first electrode and the second electrode to a preset value for generating a treatment-specific electric flux. The present invention also relates to the use of such system, as well as a process of treatment of internal organ oedema using such system.

The present invention provides a combined direct cardiac compression and aortic counterpulsation device comprising: an inflatable direct cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom, an aortic counterpulsation chamber configured when inflated to displace aortic volume for the purposes of causing a counterpulsation effect, and a driver operably connected to said inflatable direct cardiac compression jacket and to said aortic counterpulsation chamber, said driver is configured to inflate said direct cardiac compression jacket and to deflate said aortic counterpulsation chamber during systole of the heart; said driver is further configured to deflate said direct cardiac compression jacket and to inflate said aortic counterpulsation chamber during diastole of the heart.

Systems, methods, and devices to facilitate insertion of certain leads with electrode(s) into patients are described. Leads can be implanted to work in conjunction with a cardiac pacemaker or cardiac defibrillator. A lead for cardiac therapy may be inserted into an intercostal space associated with the cardiac notch of a patient. Devices for delivery may include, for example, a delivery system coupled with an electrical lead and having a handle, a component advancer and insertion tips. The handle is configured to be actuated by an operator and the component advancer is configured to advance an electrical lead into the patient. The insertion tips can be configured to close around the electrical lead within the component advancer, to push through biological tissue, and to open to enable the lead to advance into the patient. The electrical lead can also be maintained in a particular orientation during the advancement into the patient.

Disclosed is a delivery system for a component, for example, a splitting lead. A splitting lead can have a proximal portion to engage a controller and a distal portion to split apart into sub-portions that travel in multiple directions during implantation into a patient. The delivery system can include a handle and a component advancer to advance and removably engage a portion of the component. The component advancer can be coupled to the handle and advance the component into the patient by applying a force to the portion in response to actuation of the handle by the operator. Also, the delivery system can include an insertion tip with first and second ramps to facilitate advancement of first and second sub-portions into the patient in first and second directions. The leads may have various electrode configurations including, for example, wrapped or embedded electrodes, helical or elliptical coils, thin metallic plates, etc.

An electrode (10) for treating organic tissue by means of direct current, comprising an electrode holder (20), at least one electrically conductive electrode surface (30), which is let into the electrode holder (20), wherein the at least one electrode surface (30) is connected to at least one control element (400) and wherein the at least one control element (400) is connected to a control and energy supply unit by way of electrical lines (60, 70), wherein the at least one control element (400) is configured in such a way that each individual electrode surface (30) is actuable by the at least one control element (400) in such a way that a current density (J) provided within a predetermined interval for each one of the at least one electrode surfaces (30) can be maintained or that a current density (J) for each one of the at least one electrode surfaces (30) can be maintained around a predetermined value.

A radially compressible cardiac gripper for at least mechanical stimulation of a heart. The cardiac gripper has two gripper arms, wherein at least one of the gripper arms comprises a flexible section configured for movement of the arm having the flexible section.

Disclosed is a delivery system for a component, for example, a splitting lead. A splitting lead can have a proximal portion to engage a controller and a distal portion to split apart into sub-portions that travel in multiple directions during implantation into a patient. The delivery system can include a handle and a component advancer to advance and removably engage a portion of the component. The component advancer can be coupled to the handle and advance the component into the patient by applying a force to the portion in response to actuation of the handle by the operator. Also, the delivery system can include an insertion tip with first and second ramps to facilitate advancement of first and second sub-portions into the patient in first and second directions. The leads may have various electrode configurations including, for example, wrapped or embedded electrodes, helical or elliptical coils, thin metallic plates, etc.

Representative embodiments of the present invention provide for novel, minimally invasive implantable devices and methods for targeted tissue drug delivery of cardiovascular drugs.

A method for increasing left ventricular torsion by multi-point pacing includes fitting a plurality of pacemaker points at an epicardium of a heart such that the plurality of pacemaker points are positioned proximate an apex of a left ventricular muscle of the heart and sequentially pacing the plurality of pacemaker points. The left ventricular muscle of the heart twists in response to the sequential pacing. A system for implementing multi-point ventricular pacing is also provided.

The invention relates to an electromedical implantable or extracorporeally applicable device for treating and monitoring organs as well as a method for therapeutic organ treatment. The aim of the invention is to create an electromedical implantable or externally applicable device which allows healing processes to be excited in diseased organs. Said aim is achieved by an electromedical implantable or extracorporeally applicable device for treating and monitoring organs, comprising a programmable generator and receiver unit which generates and receives electrical microcurrents and electromagnetic power and is connected in a conducting manner to electrodes, a telemetry unit that is integrated into the generator and receiver unit and is provided with a transmitter and a receiver for exchanging data with extracorporeal devices, and a power supply unit.