Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.

A system for infusing medication into a mammalian subject is provided. The system includes an injection system for controlling a flow of fluid from a fluid reservoir to a needle. A sensor is provided that detects a characteristic indicative of the fluid pressure in the needle. The injection system controls the flow of fluid to the needle in response to the characteristic detected by the sensor and the sensor continuously detects the characteristic as the needle is inserted into the subject. The system further includes a conductive element for providing electric nerve stimulation, wherein the system provides electric nerve stimulation in response to the sensor detecting a pressure exceeding an upper limit.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

The present disclosure relates to subcutaneous direct current (DC) nerve conduction block. A subcutaneous electrode can be implanted under a subject's skin between the subject's skin and a neural structure within the subject's body. The subcutaneous electrode can be coupled to a current generator. A DC can be configured by the current generator and delivered through the subcutaneous electrode to block conduction in the neural structure. The subcutaneous electrode eliminates an effect of an impedance of the subject's skin on the DC. The DC can be returned to the current generator by a return electrode.

Disclosed are applicators and methods injecting of a liquid anesthetic into a dental patient with no or minimal pain. In accordance with one embodiment the applicator is for intraligamentary injection and includes an elongated, thin member having an open distal free formed of a resilient and somewhat conformable material suitable for producing a substantially fluid-tight interface with the anatomic structures at the gingival sulcus to inject the anesthetic therein. In another embodiment the applicator includes a flexible skirt surrounding a sharpened cannula, with the cannula being movable with respect to the skirt. The skirt is arranged to receive the anesthetic to anesthetize the gum, whereupon the cannula can then pierce the gum to inject the anesthetic into the underlying anatomic structure.

A wearable brain multi-stimulation pain control device is provided, comprising a main support unit, an auxiliary support unit, an audio stimulation unit, and an optical frequency-flashed stimulation unit. The main support unit includes two ear portions corresponding to a user’s ears and a front side portion, and the auxiliary support unit includes a mounting portion. Two opposite ends of the mounting portion are pivoted to the main support unit, and the audio stimulation unit includes two speakers that are respectively arranged on the ear portions and can broadcast a binaural beats with frequency following response. The optical frequency-flashed stimulation unit is arranged on the front side portion and can stimulate at least one eye of the user with flickering light, so that the user can obtain multiple stimulations at the same time in a single course of treatment to achieve the effect of improving pain.

The present invention relates to a method of medical treatment of lameness in a mammal in need thereof, the method comprising applying pulsed radiofrequency (PRF) to the mammal so that an outcome selected from the group consisting of an improvement stance or gait, a stabilization in the decrease of a deviation from normal stance or gait, a decrease of the manifestation of pain, a stabilization in the manifestation of pain, a decrease in the mechanical restrictions causing alteration of stance or gait, a stabilization in the mechanical restrictions causing alteration of stance or gait, a decrease in neuromuscular disease, a stabilization in neuromuscular disease, and/or a decrease or stabilization of inflammation is achieved.

A system for selectively blocking nerve fiber activity in a target nerve is provided. The system includes one or more electrodes. The system further includes an electronic control system electrically attached to each electrode to deliver electrical stimulation to a target nerve to block nerve signal transmission of C-fibers in the target nerve such that the nerve signal transmission of A-fibers in the target nerve providing motor function and/or low-threshold sensory function is not blocked. A method of delivering electrical stimulation to selectively block nerve fiber activity in a target nerve and a kit for performing a procedure to selectively block nerve fiber activity are disclosed.

Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.

An Implantable Pulse Generator (IPG) is disclosed that is capable of sensing a degree to which recruited neurons in a patient's tissue are firing synchronously, and of modifying a stimulation program to promote desynchronicity and to reduce paresthesia. An evoked compound action potential (ECAP) of the recruited neurons is sensed as a measure of synchronicity by at least one non-active electrode. An ECAP algorithm operable in the IPG assesses the shape of the ECAP and determines one or more ECAP shape parameters that indicate whether the recruited neurons are firing synchronously or desynchronously. If the shape parameters indicate significant synchronicity, the ECAP algorithm can adjust the stimulation program to promote desynchronous firing.