The present invention relates to an auricular neurostimulation device wearable by a user and configured to stimulate the Auricular Branch of Vagus Nerve (ABVN) on the user’s ear: the device comprises at least two electrodes designed to be located in the cymba and in the cavity of the cavum conchae respectively; the electrodes stimulate the nerve ramifications of the cymba and the cavum conchae, respectively, when an electrical voltage difference is applied between them. The invention further refers to an auricular neurostimulation system comprising an auricular neurostimulation device as described and a charging case where the device can charge an internal battery and where the device discharges into this case the data captured by the photoplethysmographic or biosensor during stimulation and sends them to a dedicated platform in the cloud. The invention also refers to a method of operation of an auricular neurostimulation system as described.

A stimulation device may include a tube, where the tube defines a lumen therein and a gas outlet. The gas outlet may be configured to allow gas to pass from the lumen to an exterior of the tube. The stimulation device may also include one or more first electrodes associated with the tube, one or more second electrodes, and a nasal cavity interface proximal of the gas outlet and the one or more first electrodes.

Systems and methods of the present disclosure are directed to neural stimulation via non-invasive sensory stimuli. The non-invasive sensory stimuli can reduce neuroinflammation, improving synaptic plasticity and stimulating neural networking, and improving microglial-mediated clearance of cerebral insults, which would otherwise contribute to the progression of brain atrophy, by inducing synchronized gamma oscillations in at least one region of a brain in a subject. Stimulations can adjust, control or otherwise manage the frequency of the neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain, while mitigating or preventing adverse consequences on a cognitive state or cognitive function that stem from progression of brain atrophy.

Disclosed is a system for associating a symptom with a medical condition. The system comprises a server arrangement, associated with a user device. The server arrangement is operable to: provide, to user device, a set of user activities; receive, from user device, information relating to selection of a user activity from set of user activities; receive, from user device, user input associated with selected user activity; analyse user input and assign performance score thereto; identify, based on performance score, one or more symptoms; and assign severity score to symptom for associating symptom with medical condition. Disclosed also is method for associating symptom with medical condition and computer program product to execute aforementioned method.

A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.

A vestibular neurostimulation device, which may include first and second electrodes; first and second thermoelectric devices thermally coupled, respectively, to first and second earpieces that are configured to be insertable into respective ear canals of a patient; and a controller comprising a waveform generator. The waveform generator may be is configured to deliver a modulated electric signal to the patient through galvanic vestibular stimulation (GVS) using the first and second electrodes and to deliver a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) using the first and second earpieces simultaneous with the delivery of the modulated electrical signal through GVS. The CVS and/or GVS may be configured to increase a passage of insulin-like growth factor 1 (IGF-1) through a blood-brain-barrier.

Provided are a method, server, and computer program for designing a customized headgear for transcranial direct current stimulation. According to one embodiment, there is provided a method for designing a customized headgear for transcranial direct current stimulation performed by a computing device and applying electrical stimulation to a preset target point in a brain of a subject, the method including: acquiring a head image of the subject; generating a headgear mask by using the acquired head image; generating a stimulator mask by using an optimal stimulation position combination for applying the electrical stimulation to the preset target point; and generating a customized headgear mask for the subject by performing a subtraction operation between the generated headgear mask and the generated stimulator mask.

Disclosed is a method of enhancing exposure therapy including providing an exposure therapy to a patient and stimulating the patient's vagus nerve at the same time as the exposure therapy. Also disclosed is a post-traumatic stress disorder therapy method including providing an exposure event to a patient and stimulating the patient's vagus nerve during the exposure event. Also disclosed is a phobia disorder therapy method including providing an extinction event to a patient and stimulating the patient's vagus nerve during the exposure event. Also disclosed is an obsessive compulsive disorder therapy method including providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event. Also disclosed is an addiction disorder therapy method including providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event.

Provided are an optimal stimulation position combination determination method using a preset guide system, a server, and a computer program. The optimal stimulation position combination determination method using a preset guide system according to various embodiments of the present invention is executed by a computing device and includes: simulating electric stimulation for a brain of a subject by using a plurality of stimulation position according to a preset guide system; and determining an optimal stimulation position combination for applying the electric stimulation to the preset target point in the brain of the subject by using a simulation result of the electric stimulation.

A method for generating stimulation parameters, an electrical stimulation control apparatus and an electrical stimulation system are provided. After receiving a brainwave signal, the brainwave signal is decomposed to obtain a first sub-signal and a second sub-signal. Then, the first sub-signal is analyzed to obtain an intrinsic frequency series, and the second sub-signal is converted to a Boolean signal. Subsequently, the intrinsic frequency series and the Boolean signal, which serve as a set of stimulation parameters, are outputted to the stimulator, enabling the stimulator to generate a stimulus signal.