Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.

Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.

Transdermal electrical stimulation (TES) applicators that are wearable and configured to attached to a subject's pinna (ear) and adapted to apply TES to modulate the subject's cognitive and/or physiological state. These apparatuses may be configured so that they can be worn against the ear (e.g., the cymba of the ear) to deliver TES. Also described herein are methods of using them to modulate a subject's cognitive state. These TES applicators may also be adapted to function as audio headphones for concurrent delivery of TES and audible signals (e.g., music).

An electrode is provided for recording electroencephalographic signals and/or for stimulating patients. The electrode includes a patient contact part and a transmission part. A layer of electrolyte material is further provided in contact with the patient's skin and interposed between the patient's skin and the contact part. The contact part and/or the transmission part includes of a soft and/or flexible material.

The invention discloses a functional electrical stimulation device including a headset, an electrical stimulation patch, an LED display screen, a circuit board, a rechargeable battery and a wireless terminal, and a method for using same. Two headphone bodies are symmetrically disposed on the headset, the circuit board and rechargeable battery are respectively mounted on the headphone bodies, and a music control button and an electrical stimulation mode and time control button are mounted on the two headphone bodies respectively. Two electrical stimulation patches are mounted on a middle portion of the headset, two LED display screens are respectively mounted on the two electrical stimulation patches. An audio decoder chip, a button control module, a power switch, an electrical stimulation generation module, a wireless communications module and a charging port are disposed on the circuit board, and the wireless terminal is independently disposed and in wireless communication with the circuit board.

A system includes ultrasound transducers configured to generate and direct ultrasound beams at a region within a portion of a subject's brain, sensors configured to measure a response from the portion of the subject's brain in response to one or more ultrasound beams, and an electronic controller in communication with the ultrasound transducers configured to generate, based on a measured response from the portion of the subject's brain in response to two or more ultrasound beams generated from two or more different angles, a model of the portion of the subject's brain, wherein the model has a higher resolution than a maximum resolution of a single ultrasound beam, and generate, based on the model of the portion of the subject's brain, stimulation parameters for the ultrasound transducers to generate and direct a stimulation ultrasound beam at the region within the portion of the subject's brain.

An optical stimulation lead includes a lead body including a distal end, a distal portion, and a proximal portion; and an optical assembly attached to the distal end of the lead body. The optical assembly includes a light emitter; a feedthrough assembly including at least one ceramic block, at least one feedthrough pin extending through the at least one ceramic block and electrically coupled to the light emitter, and a metal housing attached to the at least one ceramic block; a metal tube attached to the feedthrough assembly and disposed around the light emitter; and an emitter cover disposed over the light emitter and coupled to the metal tube.

The present invention relates to systems for providing noninvasive cranial nerve stimulation and methods for using the same. The present invention administers therapy through electrodes that are noninvasively attached to one or more of a subject's cranial nerve. The systems can be used to enhancing rehabilitation and recovery by improving neuroplasticity and coupling muscle training with feedback.

There is disclosed a system for providing transcutaneous electrical stimulation to the vagus nerve of an individual comprising: an electrode unit mountable within the auricle of the individual and having at least a first electrode and a second electrode for applying the transcutaneous electrical stimulation at the cymba conchae and the tragus of the individual's auricle, and a controller for controlling the transcutaneous electrical impulse delivered by each of the first electrode and second electrode.

An electrode system is provided for sensing and/or stimulating a brain while reducing risk associated with the sensing and stimulation. The system is scalable to different numbers of contacts to span large areas of the brain. The system includes an electrode array made with a plurality of patches connected together physically and electrically. The array and/or each patch can have its own respective intelligent multiplexer and/or intelligent demultiplexer to aggregate the respective sense and/or stimulate signals, thereby reducing the wire count down to a single wire or wireless link. The array or each patch can have an embedded ground plane, thus minimizing the susceptibility to external EM noise. Moreover, the physical resolution of the array or each patch can be adjusted as needed.