A system for use during revascularization includes a catheter having an adjustable balloon for delivery a stent, one or more pacing electrodes for delivering one or more pacing pulses to a patient's heart, and a pacemaker configured to generate the one or more pacing pulses to be delivered to the heart via the one or more pacing electrodes. The one or more pacing pulses are delivered at a rate substantially higher than the patient's intrinsic heart rate without being synchronized to the patient's intrinsic cardiac contractions, and are delivered before, during, or after an ischemic event to prevent or reduce cardiac injury.

A cable assembly for a patient treatment system comprises an electrical cable having a proximal connector configured to connect to an external electrical stimulator device and a distal connector including a distal housing having an open distal end. The distal housing houses a manifold that supports a plurality of spring-loaded electrical contact assemblies aligned in two rows and being electrically connected to a corresponding one of a plurality of electrical contacts in the proximal connector. The housing distal open end is closed by a header that is movable between a closed position resting on the housing open end and an open position spaced there above. The header has a pair of side-by-side longitudinally extending openings. With the header in the open position, a practitioner holds the distal connector in one hand and with the other hand inserts the distal electrical contacts of one or two therapy delivery devices into the longitudinally extending openings. The practitioner then moves the header into the closed position to bring the distal electrical contacts of the therapy delivery devices into firm electrical contact with the spring-loaded electrical contact assemblies housed inside the distal housing.

The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (AC) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. Methods are also provided to minimize or eliminate pain during defibrillation.

An ambulatory medical device comprising: a monitoring component comprising at least one sensing electrode for detecting a cardiac condition of a patient; at least one processor configured for: adjusting one or more detection parameters for detecting the cardiac condition of the patient based at least in part on at least one of 1) one or more environmental conditions and 2) input received from the monitoring component; and providing at least one of an alarm and a treatment in response to detecting the cardiac condition of the patient based on the adjusted one or more detection parameters.

An apparatus, a system, and methods for maintaining and monitoring an excised donor heart. The apparatus comprises a first component for receiving and submerging therein an excised heart in a constantly circulating perfusate solution and a second component comprising equipment for adjusting the temperature and oxygen content of the perfusate solution. The first component comprises an integral pair of defibrillating pads. A first conduit infrastructure interconnects the first module, the second module and an aorta of the excised donor heart pushing a perfusion solution from the first module through the second module into the aorta. The second conduit infrastructure connects the first module with the right atrium and the left atrium for pushing the perfusion solution from the first module into the atria. The third conduit infrastructure connects the first module with the pulmonary artery and provides an after pressure to the flow of the perfusion solution from the pulmonary artery.

In embodiments, a wearable cardiac defibrillator system includes an energy storage module configured to store a charge. Two electrodes can be configured to be applied to respective locations of a patient. One or more reservoirs can store one or more conductive fluids. Respective fluid deploying mechanisms can be configured to cause the fluids to be released from one or more of the reservoirs, which decreases the impedance at the patient location, and decreases discomfort for the patient. In some embodiments an impedance is sensed between the two electrodes, and the stored charge is delivered when the sensed impedance meets a discharge condition. In some embodiments, different fluids are released for different patient treatments. In some embodiments, fluid release is controlled to be in at least two doses, with an intervening pause.

A wearable medical system delivers and verifies capture of pacing pulses. The wearable medical system includes a support structure, a plurality of ECG electrodes, an energy output device coupled to an output circuit, a processor, and a plurality of therapy electrodes. The processor is in communication with the plurality of ECG electrodes and the output circuit. The processor causes a pacing pulse to be delivered to the patient via the energy output device, the output circuit, and the plurality of therapy electrodes. The processor determines whether the pacing pulse was captured by determining whether the ECG signal, within a window subsequent to a blanking period and a refractory period following delivery of the pacing pulse, meets one or more capture criteria. In response to a determination that the pacing pulse was captured, delivery of an additional pacing pulse is prevented else an additional pacing pulse is delivered to the patient.

An external ambulatory medical system configured to be worn by a patient and release a fluid to the patient's skin before providing therapy is provided. The medical system includes a garment configured to be worn about the patient's torso, a medical device controller configured to receive cardiac signals of the patient, and a plurality of therapy electrodes configured to be operably connected to the medical device controller and disposed in the garment. Each of the plurality of therapy electrodes includes a pressure source configured to provide a pressurized fluid to facilitate conductive gel deployment for the medical system. The pressure source includes a reservoir containing the pressurized fluid and at least one release mechanism configured to cause a release of the pressurized fluid from the reservoir to an exit port of the pressure source when the medical system is preparing to deliver a therapeutic shock to the patient.

A wearable medical system (WMS) includes one or more pacing capabilities. The WMS May detect when the patient's heart rhythm starts to deteriorate, but not necessarily in a way that requires Defibrillation. In particular, the WMS may detect bradycardia of one or more types, and then confirm the detection before pacing to treat the detected bradycardia.

A medical device processor is configured to receive a first cardiac electrical signal sensed from a first sensing electrode vector, receive a second cardiac electrical signal sensed from a second sensing electrode vector different than the first sensing electrode vector, and construct a third cardiac electrical signal from the first cardiac electrical signal and the second cardiac electrical signal. In some examples, the system determines sensed cardiac events according to at least one setting of a cardiac event sensing threshold control parameter from at least the third cardiac electrical signal and may determine at least one acceptable setting of a sensing control parameter based on the determined sensed cardiac events. The processor may generate an output representative of the determined sensed cardiac events.