An adapter includes a first connector, a second connector, and a circuit that reverses a polarity of a signal received at the first connector. Moreover, a lead includes a connector including a cathode terminal and an anode terminal, an electrode including a tip and a ring, and a circuit that connects the anode terminal of the connector to the tip of the electrode and that connects the cathode terminal of the connector to the ring of the electrode.

Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.

The combination microarray patch for drug delivery and electrochemotherapy device is a medical device for delivering two separate pharmaceutical preparations to a patient, as well as providing electrostimulation for electroactive pharmaceuticals. A first pharmaceutical preparation is manually delivered into the patient through a first set of drug delivery needles. Similarly, a second pharmaceutical preparation is manually delivered into a patient through a second set of drug delivery needles. A desired electrical potential may then be selectively applied across first and second sets of electrotherapy needles for electroporation to facilitate delivery of the pharmaceutical preparations. The second pharmaceutical preparation may be a conjugate of the first for targeted drug delivery.

A device (1) for bone reconstruction, has an anode (A), a cathode (C), an electrical circuit (2) to which the cathode (C) and anode (A) are connected, and an electric generator (G), preferably a current generator, for supplying power to this circuit; the device being suitable for implantation within the body of a vertebrate.

A method for determining a location of an arrhythmogenic foci (632) in or near a heart (101) includes the steps of positioning a locator assembly (100) within the heart (101), the locator assembly (100) including a plurality of electrodes (102) that receive electrical signals from the heart (101), generating a first signal array (733) from the electrical signals received by the plurality of electrodes (102) to determine an actual location of the arrhythmogenic foci (632), artificially stimulating the heart (101) based on the actual location determined by the first signal array (733) to generate a second signal array (733), and confirming the actual location of the arrhythmogenic foci (632) by comparing the first signal array (733) with the second signal array (735). In some embodiments, the locator assembly (100) includes a plurality of bipolar electrodes (102).

The invention is within the general field of electroporation. In particular, the invention is within the general field of endoscopic electroporation and relates to a bipolar electrode suitable for endoscopic use, i.e. an electrode assembly that can be inserted in a resectoscope and deployed so as to treat e.g. internal organs tumors, such as bladder, rectum or esophagus.

Electrotransport drug delivery devices, system and methods of using configured to determine if a current is present between the anode and cathode when drug is not intended to be delivered by the device. These devices/systems may include an off-current module to determine that any current (e.g., which may be inferred by measuring potential difference between the anode and cathode of the device) flowing between the anode and cathode is below a threshold value when the device is not supposed to be delivering drug, thereby preventing unintended delivery of drug and/or alerting a user that unintended delivery of drug may occur.

A device with in situ anode and cathode microneedles is used, either with or without any cosmetic, cosmeceutical, nutraceutical, and/or pharmaceutical composition or formulation. The in situ anode and cathode microneedles form battery cells or half-cells when placed in contact with an electrolyte found in bodily interface tissue, to produce an electromotive force without any additional chemical battery or power source. The microneedles may be composed of, or may carry (e.g., be coated with) electrical potential material(s) that has or have an electrical potential relative to an electrolyte in the bodily interface material. A first number of microneedles may, for instance, include a first electrical potential material having a first electrical potential. A second number of microneedles may, for instance, include a second electrical potential material having a second electrical potential. The first number of microneedles may thus serve as an anode, while the second number of microneedles may thus serve as a cathode. Alternatively, a number of microneedles may, for instance, include both a first electrical potential material and a second electrical potential material, having a first electrical potential and a second electrical potential, respectively. Respective portions of each of the microneedles may thus serve as an anode and a cathode. Again, such may be accomplished without any other or additional electrochemical battery.

Electroporation process for delivering a composition comprising at least one peptide of molecular weight ranging from 500 Da to 20 kDa

The present invention relates to an electroporation process for delivering a composition through human keratin materials, the composition comprising a peptide with a molecular weight ranging from 500 Da to 20 kDa, the electroporation process comprising the exposure of the composition in contact with said keratin materials to a succession of pulses of an electric current, the electric current being supplied by an electroporation device having an electrode (2) and a counterelectrode (3), the pulses each having a duration of between 1 ms and 5 s, with a rest interval between them of between 0.1 s and 5 s, and the electric current having a voltage amplitude ranging from 20 V to 400 V and a current ranging from 0.1 mA to 10 mA.

The present disclosure relates to a skin treatment device, the skin treatment device comprising: a main body including a control unit that controls the operation of the skin treatment device and a power source unit that supplies power to the medical skin treatment device; a transfer unit for moving the main body; and a handpiece which receives power from the power source unit of the main body, is controlled by the control unit, and has one side that comes into contact with the skin of a patient to radiate therapeutic energy below the skin surface of the patient and thus improve the skin.