A topical medication including a therapeutically effective amount of an AMPK (adenosine monophosphate-activated protein kinase) agonist for use in the treatment of one or more the human or animal medical conditions. The medical conditions include, but are not limited to: shingles (herpes zoster), post-herpetic neuralgia (PHN), gout, migraine, trigeminal neuralgia, Complex Regional Pain Syndrome (CRPS), diabetic neuropathy, peripheral neuropathy, rheumatoid arthritis, insect-related wheals, urushiol-related rash, psoriasis, herpes simplex, atopic dermatitis (eczema), contact dermatitis, allergic dermatitis, neurotrophic ulcers, first- and second-degree burns (e.g., sunburn and chemical), fibromyalgia, rubeola, and acne. Also disclosed are a method of employing the composition and a wound dressing incorporating a therapeutically effective amount of an AMPK agonist in combination with an antimicrobial agent.

A biological tissue transdermal patch houses a battery part and an active ingredient such that they do not come into contact with each other. For the use of the biological tissue transdermal patch, the battery part and the active ingredient are brought into contact to start battery reaction of the battery part and the battery part is attached to a biological tissue. Carbonized bacterial cellulose or cellulose nanofiber carbon is used for a positive electrode of the battery part.

Provided is a skin care device including a head part brought into contact with skin of a user, a battery configured to supply power for operation of the head part, a body part having a fastening portion provided at one end to which the head part is fastened and provided with the battery therein, and a cap assembly detachably attached to one end of the body part and forming an accommodation space configured to accommodate the head part, wherein the cap assembly includes a sterilization module disposed to irradiate ultraviolet light toward the head part when the cap assembly accommodates the head part.

Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., nicotine compounds for the treatment of nicotine cravings from tobacco use. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient.

A skin treatment device, adapted for delivery of an active ingredient into the human skin by means of iontophoresis, the device having electrodes to establish an electric field on the human skin, wherein the device includes an array of n electrodes with at least a first and a second electrode.

An iontophoresis system for positioning against skin of a subject is disclosed. The iontophoresis system can comprise at least one vessel having a solvent therein. An anode apparatus can couple to the at least one vessel. The anode apparatus can comprise a first reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a first electrode positioned above the first reservoir. A cathode apparatus can couple to the at least one vessel. The cathode apparatus can comprise a second reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a second electrode positioned above the second reservoir.

A device for delivery of electrical current to an area of the skin includes a first pad shaped in the form of a base having four finger-shaped protrusions; a second pad shaped in the form of a palm having a single thumb-shaped protrusion, where the first pad and the second pad each comprises a conductive layer and preferably has tabs on the edges; a first electrical connection system electrically connected to the conductive layer of the first pad; a second electrical connection system electrically connected to the conductive layer of the second pad; a controller circuit connected to the first electrical connection system and second electrical connection system; and a wearable power source. Alternatively, the device may also have the shape of a foot or other body part.

A device for increasing a concentration of at least one analyte in an advective flow of biofluid includes an agent for enhancing a paracellular permeability of an epithelial tissue; and an iontophoresis electrode and a counter electrode, which are adapted to increase the concentration of said analyte in the advective flow of the biofluid. A method of sensing an analyte in a biofluid includes increasing a paracellular permeability of an epithelial tissue layer; and inducing electro-osmotic flow by reverse iontophoresis to increase a concentration of said analyte in an advective flow of the biofluid, wherein said advective flow is driven by at least one of saliva generation, sweat generation, or reverse iontophoresis.

Disclosed are compositions that comprise an organic electrochemical mediator and a gasotransmitter salt which converts into a gasotransmitter via electron transfer. Also disclosed are bandages and wound dressings comprising the subject gasotransmitters, and methods of making a gasotransmitters, comprising exposing the compositions to a voltage sufficient to reduce the water soluble organic mediator. Further disclosed are methods of treating a variety of trauma and disease states by applying a therapeutically effective amount of at least one gasotransmitter thereto, and methods of generating an effective dose of the gasotransmitter generated from electrolytic reaction involving the gasotransmitter-generating compositions.

A device for delivery of electrical current to an area of the skin includes a first pad shaped in the form of a base having four finger-shaped protrusions; a second pad shaped in the form of a palm having a single thumb-shaped protrusion, where the first pad and the second pad each comprises a conductive layer and preferably has tabs on the edges; a first electrical connection system electrically connected to the conductive layer of the first pad; a second electrical connection system electrically connected to the conductive layer of the second pad; a controller circuit connected to the first electrical connection system and second electrical connection system; and a wearable power source. Alternatively, the device may also have the shape of a foot or other body part.