A system and method of electrotherapy for enhanced drug delivery, comprising an electrode patch and an electrotherapy apparatus providing electrical current onto the electrode patch. The electrode patch contains one or more active drug ingredients in a layer of conductive gel, and the electrotherapy apparatus provides electrical current onto the electrode patch for the enhanced drug delivery of active drug ingredients. The conductive gel is in contact with a human or animal body, and the electrode patch also includes a layer of conductive sheet, a supporting layer, and conductive connectors. The conductive gel has the viscosity allowing it to adhere to skin on a human or animal body. The active drug ingredients that can be delivered through the conductive gel include: lidocaine, capsaicin, menthol, camphor, methyl salicylate, trolamine salicylate, Arnica montana, Calendula officinalis, Hypericum perforatum, Symphytum officinale, cannabidiol (CBD) or any combination of these substances. The mass fraction of the active drug ingredients can vary from 0.001% to 30%. The electrotherapy device can be reused.

An electrically stimulated CBD infused pain-relieving patch that is placed on a human's skin that is used to relieve pain when it is connected to a controlled electrical current generating device. The electrically stimulated CBD infused pain-relieving patch comprises of a carrier that has at least one electrode, at least one conductive electrode sheet that is attached to the carrier, and a conductive gel that is placed on the electrode sheet. The conductive gel contains at least one analgesic that is selected from the group consisting of Menthol, CBD, Lidocaine or Capsaicin. The conductive gel has inactive ingredients.

Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

The present invention relates to apparatus for topical application of material for cosmetic purposes (10). The apparatus for topical application of material (10) comprises measurement apparatus configured to measure a property of skin of a human or animal subject and actuating apparatus configured to change a permeability of the skin of the human or animal subject in dependence on the measured property of the skin. The apparatus for topical application of material (10) further comprises application apparatus configured to apply material for cosmetic purposes to the skin whilst substantially no iontophoretic current flows through the skin and after the permeability of the skin has been changed.

Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

Described are methods and devices (100) for measuring a sweat property of skin (12) in response to at least one test material or component (172, 174, 176, 178). Embodiments of the device include a plurality of different sweat stimulation sites. The Sweat stimulation sites may include one or more sweat stimulant reservoirs (142, 144, 146, 148) configured to deliver a sweat stimulant to the surface of the skin (12). Embodiments may also include at least one electrode (150, 152, 154, 156, 158) for measuring a sweat property or to iontophoretically deliver the sweat stimulant from the reservoir (142, 144, 146, 148). In embodiments, the sweat stimulant is selected from acetylcholine, carbachol, methacholine, bethanechol, muscarine, pilocarpine, oxotremorine, and combinations thereof.

A device for applying a product to be distributed on user's skin by iontophoresis, includes a body intended to receive the product to be distributed, including an electric current generator; and an applicator head mounted on the body, the applicator head including: a device for distributing the product to be distributed on the skin; and a first electrode and a second electrode that are separated by an interelectrode zone, the first electrode and the second electrode to receive an electric current from the generator.

A transdermal delivery system (1) configured to deliver an active agent to human or animal tissue, comprising a penetrative electrode (2) of one polarity that provides an electrical contact (3) beneath the stratum corneum (20); a surface electrode (4) of the opposite polarisation to that of the penetrative electrode (2) that provides an electrical contact to the external surface of the skin (21) on the opposite side of the stratum corneum (20) to the electrical contact (3) of the penetrative electrode (2); a dispenser (5) configured to deliver of an active agent to the external surface of the skin (21) adjacent to an electrical contact of the surface electrode (4); a method of delivering the active agent to the tissue of a human or animal body using the transdermal delivery system (1) and an electrode assembly (10) for use in preparing the transdermal delivery system (1).

The invention provides a variety of novel devices, systems, and methods of utilizing mixed-ionic-electronic conductor (MIEC) materials adapted to function with an applied current or potential. The materials, as part of a circuit, are placed in contact with a part of a human or nonhuman animal body. A sodium selective membrane system utilizing the MIEC is also described.

The present disclosure relates to devices and systems for targeted and controlled delivery of a therapeutic agent to a treatment site of an eye. Particularly, aspects are directed to a therapeutic agent delivery device that includes a polymeric substrate having a release region, a delivery region, and a receiving region; one or more reservoirs formed within the release region; a therapeutic agent disposed within the one or more reservoirs; an active, passive, or combination thereof controlled release mechanism for release of the therapeutic agent from the one or more reservoirs into the delivery region; and a circuit formed on the polymeric substrate, the circuit having a current source, a first iontophoresis electrode located within the delivery region for transport of the therapeutic agent from the delivery region into a target tissue via electromigration, and a second iontophoresis electrode located within the receiving region for maintaining electroneutrality within the tissue.