The present disclosure generally provides methods of implanting an implantable device in contact with a brain of a subject. Also provided are kits and systems for the implantation of one or more implantable devices.

An active skull replacement system including an implant having an area A, an upper surface, and a bottom surface, adapted to be implanted at least in part into a skull of a subject so to substitute a portion of the skull, the bottom surface arranged to face at least in part a cranial cavity, and having a first wireless bidirectional data communication device, a device operably connected to the bottom surface of the implant, the device adapted to at least one of stimulate a physiological response and record a physiological parameter of the subject, and an external reader adapted to be placed on the scalp of the subject and including a second wireless bidirectional data communication device configured to communicate with the first wireless bidirectional data communication device of the implant to operate the device, wherein the external reader and the implant are fixed and aligned among each other through a magnetic device.

A device is configured to receive a catheter. The catheter may be a catheter of a ventriculoperitoneal shunt or an external ventricular drain. The device includes (ii) an upper flange having an opening, and (ii) elongate body defining a lumen in communication with the opening. The catheter may be inserted through the opening and the lumen. The device includes an electrode disposed on the elongate body. When the device is implanted in a subject, the upper flange rests on a skull of the subject adjacent to a burr hole, the elongate body is inserted through the burr hole, and the electrode is positioned intracranially in the subject.

A device for implant in a hole in cranium relative to a bone table includes a can having an electrical-contact pad. The can has a perimeter edge defining a boundary, and a recessed portion with an upper surface positioned to lie beneath the bone table when the can is placed in the hole. The device also include a cover assembly that couples to and decouples from the can at the electrical-contact pad. A strain relief system includes a lower strain relief and an upper strain relief. The lower strain relief defines channels that receive a portion of a lead and includes a curved portion that extends upward from the upper surface of the recessed portion to the bone table, and a linear portion that extends from the curved portion to an end beyond the perimeter edge. The upper strain relief couples to and decouples from the can and/or the lower strain relief.

Lead fixation devices for mounting at a cranial burr hole and securing a medical lead implanted into a brain through the burr hole. One embodiment comprises a clamp having centrally disposed clamping walls activated by a plunger having actuating tabs. The clamping walls may be an integral part of a device base, or a separate part seated in a central opening of the base. The clamp is activated by pressing the actuating tabs of the plunger into apertures adjoining the clamping walls, which displaces the clamping walls to clamp the lead. Another embodiment comprises a base having a plurality of radial and peripheral lead retention grooves configured to securely retain a substantial segment of the lead at the exit from the burr hole. Still another embodiment comprises both a clamp and peripheral retention grooves to provide a dual fixation and strain relief of the lead within the lead fixation device.

A set of shielded coils for wireless power transmission into a medical implant is described in which the external, power transmission coil is blocked at least on one side by a shield with a broken ring and radial fingers while the power receiver coil inside the medical implant is surrounded by a shield having a broken ring connecting radial fingers and ribs around its circumference. The finger and rib configurations minimizes eddy currents in the shields. A ground plane of the implant's internal circuitry, which is within the shield along with the receiver coil, can cap off the cupped receiver shield to form a Faraday cage with it. The metal or other conductive shielding prevents large electric fields from the coils from penetrating into the tissue of the subject while simultaneously allowing magnetic fields inductively couple the coils for charging. An implant with sensitive electrodes that measure minute voltages from a brain or other tissues is protected from capacitively driven voltage swings or other transients during charging.

An implantable neural tissue electrode assembly includes a cylindrical electrode lead with at least one electrode contact on the outer surface of the electrode lead. An active distal end fixation anchor is located at the distal end of the electrode lead and is adapted to fasten to adjacent tissue by rotation in a fastening direction. A passive rear fixation anchor is located on the outer surface of the electrode lead offset a longitudinal distance back from the distal end and has at least one curved blade with a blade tip directed away from rotation in the fastening direction. The rear fixation anchor is adapted to permanently fasten to adjacent tissue by rotation opposite to the fastening direction so that the blade tip cuts into the adjacent tissue, and the electrode assembly is adapted such that physiological induced strains are distributed along the electrode lead.

Systems, apparatus, and methods for treating medication refractory epilepsy are disclosed. In one embodiment, a method of treating epilepsy is disclosed comprising detecting, using a first electrode array coupled to a first endovascular carrier, an electrophysiological signal of a subject. The method further comprises analyzing the electrophysiological signal using a neuromodulation unit electrically coupled to the first electrode array and stimulating an intracorporeal target of the subject using a second electrode array coupled to a second endovascular carrier implanted within a part of a bodily vessel superior to a base of the skull of the subject.

A stimulation lead extends from a proximal end to a distal end and includes a plurality of electrodes disposed along the distal end of the lead; a plurality of terminals disposed along the proximal end of the lead; and an elongated body separating the plurality of electrodes from the plurality of terminals. The elongated body includes an outer tube of insulative material, and a cog-shaped conductor guide disposed within the outer tube. The conductor guide includes a central core and a plurality of protrusions extending outward from the central core. The plurality of protrusions and the outer tube define a plurality of pocket regions. The stimulation further includes a plurality of conductors disposed within the plurality of pocket regions, each conductor coupling at least one of the plurality of electrodes to at least one of the plurality of terminals.

A lead fixation device for attaching a deep brain stimulation lead within in a burr hole in a human skull. The lead fixation device may comprise a mounting plate having first and second arms. The first arm may comprise a first flange, a first mounting hole, and a first inner wall. The second arm may comprise a second flange, a second mounting hole, and a second inner wall. The first and second arms may comprise first and second arcuate grooves located on the first and second inner walls. When the lead device is in a closed position the first and second arcuate grooves form a guide channel and the first and second inner walls form an exit channel to receive the lead when the lead fixation device is in a closed position.