An example of a system for delivering neurostimulation energy to a patient using a plurality of electrodes may include a stimulation circuit and a sensing circuit. The stimulation circuit may be configured to deliver the neurostimulation energy using stimulation electrodes selected from the plurality of electrodes and to control the delivery of the neurostimulation energy. The sensing circuit may be configured to receive one or more neural signals from sensing electrodes selected from the plurality of electrodes and may include a signal processing circuit. The signal processing circuit may include a detection circuit and an analysis circuit. The detection circuit may be configured to detect one or more attributes of neural responses from the received one or more neural signals. The analysis circuit may be configured to analyze the detected one or more attributes of the neural responses for one or more indications of a neurodegenerative disease.

Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Cortical network structure that mediates response to brain stimulation, and associated systems and methods are disclosed herein. In one embodiment, a method for brain stimulation includes: delivering an input stimulus to an area of the brain, via a cortical implant; in response to delivering the input stimulus, generating neural signals in the brain; and generating a predicted outcome of the input stimulus. The predicted outcome is based on a set of data derived from a model that combines: protocol features that are brain agnostic, and network features that are based on interactions between neural nodes of the brain.

In rehabilitation, a stimulation pattern when applied to a body part by a neuromuscular electrical stimulation (NMES) device is effective to cause the body part to perform an intended action. The applying includes increasing a stimulation level at which the stimulation pattern is applied over time and, during the applying, acquiring video of the body part. The body part is monitored during the applying by analysis of the video, and the applying is automatically stopped in response to the monitoring indicating the body part has performed the intended action. The stimulation pattern may be defined as one or more subsets of electrodes of the NMES device and an electrode group stimulation level for each respective subset of electrodes, and the increasing of the stimulation level comprises increasing a scaling factor applied to the electrode group stimulation levels over time.

An assistance method for assisting a person in grasping or otherwise manipulating an object includes receiving video of a hand of the person and of an object. An intent to grasp the object is identified based on proximity of the hand to the object in the video or as measured by a proximity sensor, or using gaze tracking, or based on measured neural activity of the person. The object and the hand in the video are analyzed to determine an object grasping action for grasping or otherwise manipulating the object. An actuator is controlled to cause the hand to perform the determined hand action for grasping or otherwise manipulating the object.

Differential charge-balancing can be used in high-frequency neural stimulation. For example, a neural stimulation apparatus can have first and second electrodes configured to be coupled proximate to a nerve fiber to implement a neural stimulation procedure. A neural stimulation circuit can be electrically coupled to the first and second electrodes. The neural stimulation circuit can apply stimulation currents to the nerve fiber through the first and second electrodes during a first stimulation phase of the neural stimulation procedure. The neural stimulation circuit can also apply a modified stimulation current to the nerve fiber through the first electrode during a second stimulation phase of the neural stimulation procedure. The modified stimulation current can be generated based on a difference between (i) a voltage at the first electrode, and (ii) a reference voltage derived from voltages on the first and second electrodes.

Provided are a new sub-type artificial retina device, and a driving method and a manufacturing method of the sub-type artificial retina device capable of minimizing cross-talk. The sub-type artificial retina device and the driving method thereof can effectively control cross-talk, compared to conventional methods. In addition, the manufacturing method of the sub-type artificial retina device can manufacture a sub-type artificial retina device capable of effectively controlling cross-talk through a simple process, and can reduce costs.

A method for providing electrical stimulation to a user as a user performs a set of tasks during a time window, the method comprising: providing an electrical stimulation treatment, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window; for each task of the set of tasks: receiving a signal stream characterizing a neurological state of the user; from the signal stream, identifying a neurological signature characterizing the neurological state associated with the task; and modulating the electrical stimulation treatment provided to the brain region of the user based upon the neurological signature, wherein modulating comprises delivering a portion of the set of portions of the electrical stimulation treatment to the brain region of the user, while maintaining an aggregate amount of the stimulation parameter of the treatment provided during the time window below a maximum limit.

A device includes a substrate, an electrode, an electrical pad, and a signal line. The signal line is coupled to the substrate and covered by an insulation layer. The signal line is coupled to the electrical pad and the electrode. At least one of the electrode and the signal line includes a diamagnetic material and paramagnetic material, wherein a ratio of the diamagnetic material and the paramagnetic material is selected based on the susceptibility properties of a physiological tissue. The term paramagnetic herein refers to magnetic susceptibility greater than that of the surrounding tissue and diamagnetic refers to magnetic susceptibility lower than that of the tissue.