A medical apparatus for an organ has a substrate that conforms to a shape of the organ, and a plurality of processing units connected to the substrate and distributed throughout the substrate. Each of the processing units has a sensor, processing device and actuator. The sensor senses a condition of the organ and provides a sensed signal. The processing device receives the sensed signal from said sensor, analyzes the sensed signal and provides a control signal. The actuator applies an output pulse to the organ in response to the control signal from the processing device.

A system can utilize interleaving periods or waveforms to stimulate patient tissue and sense signals using the stimulation electrodes. For example, the system can utilize alternating therapeutic periods and sensing periods. As another example, the system can alternate between biphasic waveforms having opposite temporal orders of positive and negative phases. As another example, waveforms that differ in a parameter, such as amplitude or pulse width, can be interleaved to provide different information in the respective sensed signals.

A method for generating stimulation parameters, an electrical stimulation control apparatus and an electrical stimulation system are provided. After receiving a brainwave signal, the brainwave signal is decomposed to obtain a first sub-signal and a second sub-signal. Then, the first sub-signal is analyzed to obtain an intrinsic frequency series, and the second sub-signal is converted to a Boolean signal. Subsequently, the intrinsic frequency series and the Boolean signal, which serve as a set of stimulation parameters, are outputted to the stimulator, enabling the stimulator to generate a stimulus signal.

Methods and apparatuses for stimulation of the vagus nerve to treat inflammation including adjusting the stimulation based on one or more metric sensitive to patient response. The one or more metrics may include heart rate variability, level of T regulatory cells, particularly memory T regulatory cells, temperature, etc. Stimulation may be provided through an implantable microstimulator.

A neuromimetic stimulating apparatus includes a feedback detector configured to detect a feedback signal from a target to be stimulated, a controller configured to analyze a waveform of the detected feedback signal and determine a parameter based on the analyzed waveform of the detected feedback signal, and a signal generator configured to generate a stimulus signal corresponding to the detected feedback signal based on the determined parameter.

A neuromodulation system is provided herein. The system can include a cuff electrode, an electronics package, which can be part of a neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.

A method for assisting and tracking a user with a neurological disorder includes receiving, from a user interface, a selection of a physical activity that the user wishes to perform. The method further includes sending a control signal to a neurostimulation device, the control signal including instructions for the neurostimulation device to implement a neurostimulation therapy regimen corresponding to the selected physical activity that the user wishes to perform. The method also includes receiving an activity feedback signal from at least one sensor, the activity feedback signal including information regarding performance of the selected physical activity when performed by the user. The method further includes sending a monitoring signal to a remotely located caregiver device, the monitoring signal including activity data derived from the information regarding performance of the selected physical activity.

A method for estimating neural activation arising from stimulation by a stimulation system includes identifying different neural elements stimulated by the stimulation; obtaining a neural response signal resulting from the stimulation by the stimulation system; and decomposing the neural response signal to estimate neural activation of each of the different neural elements.

Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus.