An injection device comprises a housing (12) having a longitudinal axis. The injection device further comprises a dose selector (16) capable of setting a dose to be ejected from the injection device and a dose indicator comprising a units wheel (18) operatively connectable to the dose selector so that rotation of the dose selector about the longitudinal axis also rotates the units wheel, and a tens wheel (19) selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. A biasing means biases the dose indicator axially-rearwardly in the housing. An internal surface of the housing is provided with a tens housing feature selectively engageable with the tens wheel to prevent rotation thereof. An internal surface of the housing is provided with a units housing feature capable of moving the units wheel axially-forward against said biasing means such that the units wheel engages and moves the tens wheel axially-forward and free of said tens housing feature so as to allow rotation thereof.

The present disclosure is generally directed to a drive mechanism for use in a drug delivery device having a cylindrical cartridge, i.e. a handheld injection device for selecting and dispensing a number of user variable doses of a medicament. The drive mechanism includes a base element, a toothed piston rod, which is guided within and movable relative to the base element, and a drive gear having a pinion, which is rotatably held in the base element and in meshed engagement with the toothed piston rod. The toothed piston rod includes multiple rigid rod pieces which are connected by hinges. The rigid rod pieces comprise a flat plate provided with a straight toothed rack.

An injection device for setting and injecting a dose of a medicament comprises a housing) extending along an axial direction (z), a dose setting mechanism arranged in the housing, a dose dial displaceable relative to the housing for setting of the dose, a dose tracker (50; 150) operably connectable to the dose dial (12), the dose tracker is at least one of translationally or rotationally displaceable relative to the housing during setting of a dose, wherein a positional state of the dose tracker relative to the housing is indicative of a size of the dose, and a preselector configured to define a maximum dose positional state of the dose tracker relative to the housing, and a first marker provided on one of the dose tracker and the preselector and configured to indicate the positional state of the dose tracker relative to the preselector.

Embodiments including an injection device having a housing with an outer surface, an inner surface, a proximal end and a distal end, and a defining a chamber extending between the proximal end and the distal end are provided herein. The device may include a plunger having a first end and a second end, the plunger being movable proximally and distally within the chamber of the housing, the plunger comprising a plunger rod extending from the first end to the second end of the plunger; and a plunger limiting mechanism configured to interface with the plunger rod, to limit the proximal movement of the plunger and prevent removal of the plunger from the housing.

An adjustable dosage limiting device includes a member that interfaces to a plunger flange of a syringe and a barrel loop that slides along a barrel of the syringe. A locking mechanism, when engaged, fixes a distance between the member that interfaces to a plunger flange and the barrel loop, and hence, locks the barrel loop in place with respect to the plunger flange. Once locked in place, the adjustable dosage limiting device limits a dosage provided by the syringe based upon a distance between the member that interfaces to a plunger flange and the barrel loop as set by the locking mechanism.

A medicament delivery device is presented for administering a therapeutic substance from a multi-chamber cartridge. The medicament delivery device performs a mixing process to create the therapeutic substance for delivery within the multi-chambered cartridge, where the delivery device includes a distal part comprising a dose setting mechanism having a housing, a dose setting knob, an injection button, a piston rod capable of moving axially along the longitudinal axis of the housing during dose delivery, and a return ring configured to reset the piston rod to a starting position. The delivery device also includes a proximal part comprising a cartridge holder configured to accept a multi-chambered cartridge, where the cartridge holder comprises a screw driven sleeve configured for attachment to the distal part and where rotation of the screw driven sleeve performs a medicament mixing process within the multi-chambered cartridge.

Therapeutic agent delivery devices having integrated pain mitigation are provided. Aspects of the devices include a therapeutic agent delivery system; and an actuator component, where the therapeutic agent delivery system is present in a receiving space of the actuator component. The therapeutic agent delivery system includes dmg container, a needle and a tissue contacting tip. The actuator component includes a therapeutic agent delivery system actuator and a pain mitigation system. Also provided are methods of using the devices, as well as kits that include various components of the systems.

Ratchet-based drive systems for more reliable and safer drug delivery are provided. The ratchet-based drive systems restrict angular movement and/or linear movement of components that cause a plunger to expel a liquid drug from a drug container. Movement of the components can be restricted to correspond to a predetermined or desired portion of the liquid drug. In the case that control of the drive system is lost or fails, the maximum amount of drug that could be delivered is limited to a known amount, thereby reducing the likelihood of an overdose.

A drive mechanism for an injection device includes an inner body fixable inside a housing. An elongated shaft of the inner body extends in an axial direction. The shaft includes an outer thread and a blocking structure on an outer circumference. A tubular-shaped display member has an inner thread engaged with the outer thread of the inner body (20). A dose member is axially displaceable between a dose setting position and a dose dispensing position relative to the display member. The dose member includes at least one blocking element displaceable, pivotable or bendable in radial direction between a blocking position and a release position and engageable with the blocking structure for inducing a radial displacement of the blocking element. In the blocking position, the blocking element axially abuts with the blocking structure and with the display member to block an axial displacement of the dose member from the dose setting position towards the dose dispensing position.

An injection device for setting and injecting a dose of a medicament is provided. The injection device includes: an elongated housing extending along a longitudinal axis (z) and comprising a sidewall, a dose tracker having a portion arranged inside the housing, the dose tracker comprising at least one tracking stop feature, wherein a positional state of the dose tracker relative to the housing is indicative of a size of the dose, and a preselector comprising a preselector stop feature. Wherein the tracking stop feature and the preselector stop feature are configured to mutually engage and to block a displacement of the dose tracker beyond a predefined maximum dose positional or rotational state. The preselector is at least one of translationally or rotationally displaceable relative to the housing along a displacement path between at least two preselection positional states.