Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications. In particular embodiments, aspects of the foregoing modulation therapies may be implemented by systems and devices that have simplified functionalities.

A skull-implantable electrode assembly for delivering pulses of electric current to a patient's brain, comprising an electrode housed in an insulated conduit and threaded through an electrically-conductive cannulated skull screw. Details of the exterior construction are discussed, as well as electrode arrangements and methods of treating a medical ailment of a patient.

A therapy method (for a patient having post-traumatic stress disorder (PTSD)) includes providing an exposure event to the patient which is related to a traumatic event that contributed to the PTSD. A therapy method (for a patient having a phobia disorder) includes providing an extinction event to the patient which is related to something that contributed to the phobia disorder. A therapy method (for a patient having an obsessive-compulsive disorder (OCD)) includes providing a therapy event to the patient which is related to something that contributed to the OCD. A therapy method (for a patient having an addiction disorder) includes providing a therapy event to the patient which is related to one or more things that contributed to the addiction disorder. Each of the therapy methods further includes providing vagus nerve stimulation to the patient electrically in temporal proximity to the corresponding exposure event, extinction event or therapy event.

The present invention provides, inter alia, methods, apparatus, and systems useful for ameliorating impulse control disorders known to be extremely disabling and common to many neurological and psychiatric conditions using closed-loop (responsive) neuro stimulation.

Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications. In particular embodiments, aspects of the foregoing modulation therapies may be implemented by systems and devices that have simplified functionalities.

A cholinergic deep brain stimulator is provided that can be used to increase brain acetylcholine levels. This increase in acetylcholine levels improves cognition and may be used to remediate disorders in which cognitive loss is a prominent symptom including Alzheimer's Disease, vascular dementia, traumatic brain injury, or drug addiction.

Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications. In particular embodiments, aspects of the foregoing modulation therapies may be implemented by systems and devices that have simplified functionalities.

A pulse generator includes a processor. The processor is configured to: sense the electrophysiological activity of a patient by using an electrode wire to obtain an electrophysiological signal of the patient; input the electrophysiological signal of the patient into a state classification model to obtain a state classification result of the patient; acquire desired configuration information of the pulse generator corresponding to the state classification result of the patient; detect whether the current configuration information of the pulse generator matches the desired configuration information, if not, execute the step of updating, and if yes, execute the step of sensing after a first preset duration; and update one or more stimulation parameters of the pulse generator by using the desired configuration information of the pulse generator and execute the step of sensing after a second preset duration, where the second preset duration is less than the first preset duration.

The present invention relates to methods of treating or preventing addiction and relapse use of addictive agents where the method comprises: (a) administering to a subject a co-therapy treatment with an auricular or peri-auricular electro-acupuncture or neurostimulation device, (b) co-treatment with at least one non-narcotic detoxification agent and (c) administering to the subject an opioid antagonist. The methods and compositions of the invention are useful in the treatment or prevention of addiction to any agent, including alcohol, nicotine, marijuana, cocaine, and amphetamines, as well as compulsive and addictive behaviors, including pathological gambling and pathological overeating.

Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal for stimulating and/or sensing activity of media proximal to the devices. The media can include tissue and/or fluid. A method of controlling an apparatus in communication with a brain machine interface. The method can include measuring a first neural activity in a first neural area and measuring a second neural activity in a second neural area. The first neural activity can be associated with a first intent. The method can include creating and delivering, via the processor, one or more first control signals to the apparatus upon comparing the second neural activity with the first neural activity, and confirming, based on this comparison, that the second neural activity is associated with the first intent.