Devices, systems and methods of neurostimulation for treating obstructive sleep apnea. The system is adapted to send an electrical signal from an implanted neurostimulator through a stimulation lead to a patient's nerve at an appropriate phase of the respiratory cycle based on input from a respiration sensing lead. External components are adapted for wireless communication with the neurostimulator. The neurostimulator is adapted to deliver therapeutic stimulation based on inputs.

A neuromodulation system configured for providing sub-threshold neuromodulation therapy to a patient. The neuromodulation system comprises a neuromodulation lead having at least one electrode configured for being implanted along a spinal cord of a patient, a plurality of electrical terminals configured for being respectively coupled to the at least one electrode, modulation output circuitry configured for delivering sub-threshold modulation energy to active ones of the at least one electrode, and control/processing circuitry configured for selecting a percentage from a plurality of percentages based on a known longitudinal location of the neuromodulation lead relative to the spinal cord, computing an amplitude value as a function of the selected percentage, and controlling the modulation output circuitry to deliver sub-threshold modulation energy to the patient at the computed amplitude value.

A neuromodulation device generates a therapeutic neuromodulation field to produce a therapeutic effect in therapy-targeted neural tissue, and a priming field to produce a priming effect in priming-targeted neural tissue. The priming effect causes a change in sensitization of the priming-targeted neural tissue to the therapeutic neuromodulation field. The priming field is generated concurrently during generation of the therapeutic neuromodulation field to increase efficacy of the therapeutic effect.

An electroceutical apparatus and self-care method for treating pain by providing Transcutaneous Electrical Nerve Stimulation (TENS) in combination with pulsed Ultrasound or Light Emitting Diode (LED) treatments. In some embodiments, the apparatus includes a pod unit and a controller, and wrap for holding the pod unit on an area of a user's body. In some embodiments, the wrap may include electrodes and the intensity of the TENS treatment may be adjusted by a user via the controller. In some embodiments, the frequency or output of the treatments is fixed and sequentially delivered to the user in a timed manner.

A method or system for generating a clinical effects map for electrical stimulation includes receiving stimulation parameters and at least one clinical response for each of a plurality of stimulation instances; for each of the stimulation instances, determining a radius of a stimulation field according to the stimulation parameters for the stimulation instance; generating the clinical effects map using the at least one clinical response and the stimulation parameters for each of the stimulation instances, wherein, for each of the stimulation instances, the at least one clinical response for the stimulation instance is assigned to the radius of the stimulation field determined for the stimulation instance; and displaying the clinical effects map.

A method for determining an intensity index for electrical stimulation includes receiving stimulation information; determining a stimulation field from the stimulation information; determining at least one stimulation field function using the stimulation field; and analyzing the determined at least one stimulation field function to determine the intensity index. The intensity index corresponds to a stimulation target and indexes at least one dosing reference for electrical stimulation for that stimulation target.

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Methods for electrically stimulating body tissues to improve function or reduce symptoms provide an electrical stimulation system having two or more electrodes that are capable of being switched independently from a hyperpolarizing (depolarizing) state to a hypopolarizing state. Multiple combinations of hyperpolarizing electrodes and hypopolarizing electrodes are created by polarity switching to determine a polarity configuration having the best performance as determined by symptom reporting and clinical diagnostic tests. Polarity switching is triggered manually or is programmed to be switched automatically. Determining the configuration providing electrical stimulation resulting in the greatest benefit allows the system to be operated with one or more electrodes in a hypopolarizing state, thereby reducing energy requirements, tissue tolerance, and tissue fatigue.

Process and electrostimulation equipment employed in controlling pains of various etiologies, the process predicting the development of an electrostimulation protocol in which the variation of electrical pulses intensity is performed in a random fashion, respecting the limits of stimulation efficiency, in order to reduce the physiological phenomenon of nerve fiber accommodation to the stimuli, the electrostimulation portable equipment, having of a bandage, and having a central electronic module and two lateral flaps, which contain the respective electrodes covered by gel layers removable protective sheets. The module houses the internal components and the electric circuit equipment, power battery, which is a coin-shaped lithium-ion battery. The equipment includes power source, step-up regulator, micro controller, power supply seal, boost source, H-bridge, and electrode output, and switch off module.

An implantable pulse generator system includes a nerve stimulation unit providing vagal nerve stimulation (VNS) pulses; an autonomic tone sensor which determines the patient's autonomic status; and a control unit connected to the nerve stimulation unit and the autonomic tone sensor. The control unit controls the nerve stimulation unit to generate VNS with varying intensity, depending on the autonomic status (which is evaluated in a moving window). The control unit gradually increases VNS intensity when the autonomic status indicates a shift toward more sympathetic dominance, and it gradually decreases VNS intensity when the autonomic status indicates a shift toward more parasympathetic dominance, wherein the gradual increase and the gradual decrease of the VNS intensity follow two different paths.