Provided herein are membrane separation systems and methods suitable for use in separating carbonylation catalyst from a beta-lactone product stream. Such membrane separation systems utilize a cross flow separation technique and employ a sweep stream.

A gas separation system for controlling a concentration of a first gas species and a second gas species in an outlet gas comprises a splitter unit. The splitter unit comprises a gas membrane system having a gas inlet port. The gas inlet port is in fluid connection with an air intake. A membrane is a selective barrier and allows some things to pass through but stops others.

The present disclosure provides a system for refining long chain dicarboxylic acid, comprising: a first membrane filtration unit, for a first membrane filtration of a long chain dicarboxylic acid fermentation broth or a treated liquid therefrom; a first decolorization unit, for carrying out a first decolorization treatment to the filtrate obtained after the membrane filtration; a first acidification/crystallization unit, for carrying out a first acidification/crystallization of a filtrate obtained after the membrane filtration to give a solid-liquid mixture; a first separation unit, for a solid-liquid separation of the solid-liquid mixture; a drying unit, for drying the solid separated by the separation unit to give a first solid. By using the refining system according to the present disclosure, the purity of the obtained product is high, and the disadvantages such as poor quality of the product obtained by crystallization from a solvent and environment pollution caused by a solvent can be overcome.

Embodiments of the disclosure provide a method for evaluating dialyzers used in different medical applications (e.g., hemodialysis). Red blood cell volume lost in a dialyzer is monitored by obtaining blood flowrate measurements and hematocrit measurements at input ports and output ports of the dialyzer. The flowrate and hematocrit measurements are used to determine an accumulation of red cell blood volume in the dialyzer. The measurements may be obtained in a lab environment with an in-vitro blood source or may be obtained in a clinical setting with an in-vivo blood source from a patient.

A spiral wound module assembly including a plurality of serially arranged spiral wound modules axially aligned within a chamber of a pressure vessel, wherein each spiral wound module includes at least one membrane envelope wound about a permeate collection tube and wherein the permeate collection tubes of each spiral wound module are in sealed fluid communication with each other and with a permeate adaptor tube that extends to a permeate outlet port, and wherein the assembly is characterized by including a monitoring system including a set of sensors in contact with the inner periphery of the permeate adaptor tube and a micro-processing unit located within the vessel and connected to the sensors.

A spiral wound module assembly including a plurality of serially arranged spiral wound modules axially aligned within a chamber of a pressure vessel, wherein each spiral wound module includes at least one membrane envelope wound about a permeate collection tube and wherein the permeate collection tubes of each spiral wound module are in sealed fluid communication with each other and with a permeate adaptor tube that extends to a permeate outlet port, and wherein the assembly is characterized by including a monitoring system including a set of sensors in contact with the inner periphery of the permeate adaptor tube and a micro-processing unit located within the vessel and connected to the sensors.

The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.

The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.

A method includes measuring, by a flow sensor (70), a flow rate of a permeate fluid (48) flowing through a filter (20) of a membrane filtration system (12). Further, the method includes receiving, by a control unit (86), the measured flow rate of the permeate fluid (48) and determining, by the control unit (86), a first flux rate of the filter (20) based on the measured flow rate of the permeate fluid (48). Furthermore, the method includes comparing, by the control unit (86), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (12), by the control unit (86), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system (12) is further based on a determined normalized water permeability value of the filter (20).

A method includes measuring, by a flow sensor (70), a flow rate of a permeate fluid (48) flowing through a filter (20) of a membrane filtration system (12). Further, the method includes receiving, by a control unit (86), the measured flow rate of the permeate fluid (48) and determining, by the control unit (86), a first flux rate of the filter (20) based on the measured flow rate of the permeate fluid (48). Furthermore, the method includes comparing, by the control unit (86), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (12), by the control unit (86), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system (12) is further based on a determined normalized water permeability value of the filter (20).