A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.

A separation membrane module a tubular housing, a monolith type membrane structure housed in the housing, and a first flow regulation portion housed in the housing. The housing has an inner circumferential surface and a first opening formed in the inner circumferential surface and configured to allow a sweep gas to flow therethrough. The membrane structure has an outer circumferential surface and a first slit formed in the outer circumferential surface and configured to allow the sweep gas to flow therethrough. The first flow regulation portion has a first flow regulation surface configured to regulate a flow of the sweep gas between the first opening and the first slit.

Described is a gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet. The gas exchanger also includes: a hollow fiber bundle disposed within the housing between the core and the outer wall; and a gas inlet compartment for receiving an oxygen supply and directing the oxygen supply to first ends of the hollow fiber bundle, wherein the gas inlet compartment includes at least one restriction element configured to allow the oxygen supply to reach only a portion of the hollow fiber bundle.

Provided is a fuel cell membrane humidifier in which humidification efficiency is improved by preventing differential pressure loss in a humidification module. The fuel cell membrane humidifier performs moisture exchange between a first fluid and a second fluid and includes a mid-case, a second fluid inlet through which the second fluid is introduced into the mid-case, a second fluid outlet through which the second fluid is discharged to outside, a partition wall configured to divide an inner space of the mid-case into a first space and a second space, and at least one cartridge located in the mid-case and configured to accommodate a plurality of hollow fiber membranes therein. A cross-sectional area of the second fluid inlet is equal to or greater than a total area of windows constituting a first mesh hole unit and arranged in a mesh shape in the at least one cartridge for fluid communication with the first space.

In some embodiments thereof, the present invention describes TFF (Tangential Flow Filtration) filtration devices that utilize tubular membranes for the separation of cells and particles. These devices encompass several innovative features, including the use of membrane tubes with either circular or non-circular cross-sections. These tubes are closely surrounded by both tube housing and filter housing to regulate the pressure of the liquid exiting the filter housing. Additionally, the membrane tubes may feature internal cores within their lumens and/or structures along their inner walls. These internal features serve to regulate flow patterns and pressures within the tubes. One notable aspect of this invention is the inclusion of features on the tube housing or tube core that effectively regulate pressure resistance and feed flow patterns. These features lead to a reduction in the required recirculation rate and contribute to improved transmembrane pressure profiles, making these membrane filters highly effective for cell retention in cell culture and other applications. The patent also introduces various filter designs that incorporate tubular membranes into TFF filtration devices to achieve multiple goals, including a more consistent TMP (Transmembrane Pressure) profile for efficient separation, reduced recirculation rates to generate adequate shear rates, higher packing densities of membrane surface areas within the same filter design, and enhanced manufacturability and recyclability of the filters. Overall, this invention represents a significant advancement in the field of TFF filtration, offering innovative solutions for a wide range of applications in the separation of cells and particles.

A cross-flow filtration device comprises a retentate plate, a permeate plate, and a membrane sandwiched between the retentate plate and the permeate plate. The retentate plate comprises at least one feed channel extending from a distribution manifold, and at least one drain channel extending from a collection manifold, and a feed channel is fluidly connected to a drain channel via through-holes extending from a first side of the retentate plate, from a feed channel, to an opposing second side of the retentate plate, and through-holes extending from the second side of the retentate plate to the first side of the retentate plate, into a drain channel. One or more of the through-holes extending from the feed channel have a chamfered inlet.

Described is a gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet. The gas exchanger also includes: a hollow fiber bundle disposed within the housing between the core and the outer wall; and a gas inlet compartment for receiving an oxygen supply and directing the oxygen supply to first ends of the hollow fiber bundle, wherein the gas inlet compartment includes at least one restriction element configured to allow the oxygen supply to reach only a portion of the hollow fiber bundle.

A gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet. The gas exchanger also includes a hollow fiber bundle disposed within the housing between the core and the outer wall, and a gas inlet compartment for receiving an oxygen supply and directing the oxygen supply to the first ends of the hollow fiber bundle, wherein the gas inlet compartment includes at least one restriction element configured to allow the oxygen supply to reach only a portion of the hollow fiber bundle.

A filter flow management system includes a cartridge having an inlet through which fluid flow can be introduced to the cartridge, a plurality of channels situated within the cartridge and designed to remove particulates from the fluid flow, at least one channel being in fluid communication with the inlet to receive the fluid flow, and a reservoir into which fluid flow flowing through the at least one channel can be directed and subsequently redirected into at least one other channel.

A reverse osmosis arrangement is described, the first chamber (5) having a first port (7) and a second port (8) and the second chamber (6) being connected to a permeate outlet (9), wherein the first port (7) is connected to a first pump (13). Such a reverse osmosis arrangement should be operated with high efficiency. To this end the second port (8) is connected to a second pump (14).