A disposable filter cup and stem assembly with a filter disc or membrane secured between the cup and the stem. A frangible filter cup disengagement strip is formed on the filter cup about an end adjacent the stem. The filter disc or membrane is secured in the assembly in close proximity to the disengagement strip. Force applied to the disengagement strip separates the filter cup from the stem to expose the top, upstream surface of the filter disc or membrane and to permit removal of the filter disc from the assembly in an intact, substantially horizontal position. A disposable filter capsule assembly formed with a frangible filter capsule disengagement strip encloses a filter disc or membrane and permits separation of the capsule into two sections so as to expose an upstream surface of the filter disc or membrane and to permit removal of the filter disc or membrane in an intact condition after fluid processing. Disposable filter capsules with capsule halves having mated snap-fit surfaces and optional O-ring or luer lock type sealing surfaces, permit access to enclosed filter discs or membranes after fluid processing. Upon separation of the filter capsule halves, the upstream surfaces of the enclosed filter discs or membranes are exposed and the discs or membranes are accessible for removal in intact condition. O-ring free media holders constructed with weld spots permit access to enclosed free media by disengaging the weld spots after fluid processing.

The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first shell (16) disposed on a front face (5) of said base (2) and a second shell (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20).

A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

This disclosure relates to the use of a hydrophobic hollow fiber filter for the filtration of cell cultures and other biological perfusions, due to its resistance to fouling, as well as the ability to filter solutions with a high solid content. A hydrophobic hollow fiber filter may be used within a filter housing in conjunction with a process vessel and a traditional separation system. When the system is used with alternating tangential flow or tangential flow filtration, the hydrophobic hollow fiber filter results in more effective filtration of the filtrate, leading to greater concentration of the retentate, even in solution containing high levels of solids.

A single-use filtration device (10) comprises a plurality of single-use filter capsules (12) connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder (14). The filter capsules (12), in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules (12), are preconfigured for a desired filtration process.

Cassettes for tangential flow filtration (TFF) are disclosed which reduce assembly and disassembly required for aseptic filtration. Packaging systems and methods for the TFF cassettes are also disclosed.

The present disclosure relates to a filter capsule that supports direct integrity testing of an internal filter element. The filter capsule includes a filter housing having an inlet port, an outlet port, a passage running longitudinally between the inlet port and outlet port and holding a filter element, and an aseptic vent assembly. The filter housing also includes an integrity test assembly that can be used as a direct connection for integrity testing hardware, as opposed to upstream of the filter capsule. In one embodiment, the integrity test assembly comprises a body having a bore formed through its interior and a movable plunger within the bore. The plunger includes a handle to move the plunger between a closed position and an open position. Various seals between the plunger and the bore form a fluid tight seal between various portions of the plunger and the bore.

The proposed prefabricated filtration module (10) is provided for a modular filtration system, in particular a cross-flow filtration system, for low-volume screening applications. The prefabricated filtration module (10) includes fluid ports (24) and a plurality of components adjusted to low-volume screening applications, which are firmly integrated into the filtration module (10). The entire filtration module (10) is designed as a single-use filtration module.

A plasma separator includes a vertical chamber with a membrane or membranes partially or fully covering the internal chamber walls and forming an inner cavity to accommodate whole blood. The plasma separator further includes a plasma collection space separated from the inner cavity with one or more membranes and a plasma removal port.

In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.