An automatic analysis device includes a processing unit 3 which performs the treatment on a specimen before analysis of the specimen, supply equipment which supplies a reagent to a reaction vessel 11 disposed in the processing unit 3, a liquid temperature adjusting unit 1 which adjusts a temperature of the reagent supplied to the reaction vessel 11 by the supply equipment, a control unit 201, and a first temperature detection unit 4 which detects at least one temperature of a temperature of the air within the processing unit 3 and a temperature of the reagent supplied to the reaction vessel 11, in which the liquid temperature adjusting unit 1 and the control unit 201 execute temperature adjustment of the reagent based on a first temperature detected by the first temperature detection unit 4.

A container may include a storage volume configured to store a payload. A thermal insulation layer may surround the storage volume. A thermoregulation layer may surround the thermal insulation layer. There may be activation of a chemical reaction in the thermoregulation layer. The thermal insulation layer may have R-value per inch configured to expose the payload to a desired temperature to ensure viability of the payload and dampen a temperature spike of the chemical reaction. A system of containers may include a system storage volume with N containers in the system storage volume, wherein N is a whole number of 2 or more. A method of making an insulated container may include preparing an outer skin barrier layer, stacking a thermoregulation layer on the outer skin barrier layer, stacking a thermal insulation layer on the thermoregulation layer, and stacking an inner skin barrier layer on the thermal insulation layer.

Embodiments of the present disclosure generally relate to diagnostic apparatus and uses thereof. The apparatus and methods described herein can be useful for, e.g., rapid detection of SARS- and SARS-related coronaviruses. In an embodiment is provided an apparatus for detecting a nucleotide sequence that includes a fluidic channel coupled to one or more reservoirs, the fluidic channel comprising a sample introduction component, a polymerase chain reaction component, and a detection component. The apparatus further includes a temperature control device to heat or cool the fluidic channel, one or more sensors to detect the presence or absence of a magnetic nanoparticle, and a processor coupled to the one or more sensors and to the temperature control device. In another embodiment is provided a method for detecting an analyte that includes introducing a sample to an apparatus described herein, performing one or more processes to the sample, and detecting the analyte.

A method is provided comprising loading shells into shell retention chambers of a shell management module, the shells including corresponding reservoirs configured to hold individual quantities of liquid, the shell retention chambers arranged in a predetermined pattern on a platform of the shell management module. The method further comprises orienting discharge ends of the shells along an actuation direction within the shell retention chambers, and covering the discharge ends with closure lids to seal bottoms of the corresponding reservoirs.

A method of processing and storing biological cells includes introducing a flowable medium into a microfluidic device, the flowable medium including biological cells; sequestering one or more biological cells from the flowable medium in one or more isolation regions of the microfluidic device; and freezing the microfluidic device including the one or more biological cells sequestered therein.

Methods, sample vessels, and instruments are provided for determining antibiotic resistance of a bacterium.

Provided herein and methods and apparatuses for sequencing nucleic acids. For example, provided is an analytical detection apparatus, including (a) a stage configured to support a flow cell; (b) a detector configured to observe a detection channel of the flow cell when the flow cell is supported by the stage; (c) a plurality of fluid delivery channels, wherein each of the fluid delivery channels fluidically connects a reservoir to the detection channel of the flow cell; and (d) a first heater configured to heat the plurality of fluid delivery channels.

Air-matrix digital microfluidics (DMF) apparatuses and methods of using them to prevent or limit evaporation and surface fouling of the DMF apparatus. In particular, described herein are air-matrix DMF apparatuses and methods of using them in which a separate well that is accessible from the air gap of the DMF apparatus isolates a reaction droplet by including a cover to prevent evaporation. The cover may be a lid or cap, or it may be an oil or wax material within the well. The opening into the well and/or the well itself may include actuation electrodes to allow the droplet to be placed into, and in some cases removed from, the well. Also described herein are air-matrix DMF apparatuses and methods of using them including thermally controllable regions with a wax material that may be used to selectively encapsulate a reaction droplet in the air gap of the apparatus.

Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

Proposed are an all-in-one kit for on-site molecular diagnosis and a molecular diagnosis method using the same. The kit includes a first component including a sample pre-processing part, a nucleic acid adsorption part, and a nucleic acid amplification part, and a second component including a detection part. The sample pre-processing part includes a transfer member for transferring a lysis buffer where a nucleic acid is dissolved and functions to pre-processes a sample. The nucleic acid adsorption part is positioned on the sample pre-processing part and is configured to be slidable onto the nucleic acid amplification part. The nucleic acid amplification part is connected to the sample pre-processing part and functions to elute the nucleic acid from the nucleic acid adsorption part and to amplify the eluted nucleic acid. The detection part functions to transfer the nucleic acid amplified by the nucleic acid amplification part and to detect the nucleic acid.