Provided are a manufacturing method of a plate precursor having a plurality of needle-like protrusions and a manufacturing method of a microneedle array, which make it possible to manufacture a plate precursor within a short period of time. A manufacturing method of a plate precursor having a needle-like protrusion includes: a preparation step of preparing a cutting tool including at least one blade conforming to an external shape of the needle-like protrusion, and a base material; and a cutting step of cutting the base material by rotating the cutting tool about a tool axis of the cutting tool and revolving the cutting tool around an axis of the needle-like protrusion to be formed on the base material to form the needle-like protrusion having a shape conforming to a shape of the cutting tool.

The present invention includes producing a preliminary mold (10-1 or 20-1) provided with two-dimensional patterns (111 or 211) having a shape of a microneedle array (30) therein; producing microneedle array molds (10 and 10-2 or 20 and 20-2) having a three-dimensional shape by expanding air inside the patterns (111 or 211) having a two-dimensional shape to deform the patterns (111 or 211) having the two-dimensional shape into molds having the three-dimensional shape; and after pouring a biodegradable resin into the microneedle array molds (10 and 10-2 or 20 and 20-2) and solidifying the biodegradable resin, completing the microneedle array (30) by removing the microneedle array molds (10 and 10-2 or 20 and 20-2), thereby providing a mold for production of a microneedle array and a production method of the microneedle array using the same capable of tightly suturing an affected area without inducing pain.

A reusable mold for injection molding and molding method includes a reusable mold member, a mold cavity defined in the mold member, and at least one heat sink recess defined in the mold member for accommodating a heat sink material. The mold member is mounted on a liquid cooled mold platen. Heat is rapidly removed from the mold cavity when the mold member is used to injection mold a molded part through the heat sink material and through an interface between the heat sink material and the liquid-cooled mold platen. The reusable mold injection molds a molded part and rapidly removes heat from the mold cavity via the heat sink material accommodated in the at least one heat sink recess and through the liquid-cooled platen.

A reusable mold for injection molding and molding method includes a reusable mold member, a mold cavity defined in the mold member, and at least one heat sink recess defined in the mold member for accommodating a heat sink material. The mold member is mounted on a liquid cooled mold platen. Heat is rapidly removed from the mold cavity when the mold member is used to injection mold a molded part through the heat sink material and through an interface between the heat sink material and the liquid-cooled mold platen. The reusable mold injection molds a molded part and rapidly removes heat from the mold cavity via the heat sink material accommodated in the at least one heat sink recess and through the liquid-cooled platen.

A method including inserting into a mold a first tool having a first surface. The method further includes printing a second tool from a polymer material and inserting the second tool into the first tool. The second tool having a smaller wall thickness than the first tool and including a second surface opposing and in contact with the first surface of the first tool and a third surface formed on an opposite side of the second tool than the second surface.

Provided is a method for manufacturing a microneedle array, which enables efficient and stable manufacturing of a microneedle array including a needle-shaped protrusion having a constricted shape. The method for manufacturing a microneedle array includes: a first cutting step of forming a needle-shaped protrusion by cutting a base material by a first cutting tool; a second cutting step of forming a constricted shape in the needle-shaped protrusion by cutting a part of the needle-shaped protrusion by a second cutting tool different from the first cutting tool; a mold forming step of molding, from a plate precursor manufactured through the first cutting step and the second cutting step, a resin mold having a needle-shaped hole which has an inverted shape of the plate precursor; a first array manufacturing step of filling the needle-shaped hole of the resin mold with a drug solution and then drying the drug solution; a second array manufacturing step of filling the needle-shaped hole with a base material solution and drying the base material solution, after the first array manufacturing step; and a peeling step of peeling, from the resin mold, a microneedle array manufactured by the resin mold.

A device for expanding and shaping the end of pipes includes a head with means for connecting to an elastically deformable expanding element with a first elongated portion for being introduced into the end of the pipe, the expanding element having a central through hole, and an extracting member including an expansion head suitable to move from outside to inside the central through hole of the expanding element or the other way round, so as to cause deformation, or to allow the expanding element to elastically return to an undeformed state, means for moving said extracting member, wherein: —the connecting means is suitable for steadily constraining the expanding element to the head for a plurality of different pipes and to allow the expanding element to be replaced when worn out, the elongated portion of the expanding element is made of an elastically deformable polyurethane plastic material having certain characteristics.

A device for expanding and shaping the end of pipes includes a head with means for connecting to an elastically deformable expanding element with a first elongated portion for being introduced into the end of the pipe, the expanding element having a central through hole, and an extracting member including an expansion head suitable to move from outside to inside the central through hole of the expanding element or the other way round, so as to cause deformation, or to allow the expanding element to elastically return to an undeformed state, means for moving said extracting member, wherein: —the connecting means is suitable for steadily constraining the expanding element to the head for a plurality of different pipes and to allow the expanding element to be replaced when worn out, the elongated portion of the expanding element is made of an elastically deformable polyurethane plastic material having certain characteristics.

A method of deposition is disclosed. The method can include dispensing a formable material over a substrate, where the substrate includes a non-uniform surface topography, and where the substrate includes an active zone and an exclusion zone. The method can also include curing the formable material in the exclusion zone to form a circular edge between the exclusion zone and the active zone, contacting the formable material with a superstrate, and curing the formable material in the active zone to form a layer over the substrate, wherein curing is performed while the superstrate is contacting the formable material.

Disclosed are a negative pressure driven sucking apparatus and a preparation method thereof. The sucking apparatus comprises a sucking disc body, wherein a negative pressure cavity is formed in the middle of the sucking disc body, and the negative pressure cavity is connected with a vacuum line, and the bottom of the negative pressure cavity having a flexible section, and an annular wedge-shaped microstructure is formed at the bottom of the body surrounding the flexible section. Stable loading and release processes of the annular wedge-shaped microstructure are realized.