A vibrating gastrointestinal capsule and method of use thereof for treating Parkinsonism in a subject, the method including: (a) providing a vibrating gastrointestinal capsule having a housing; a vibrating agitation mechanism adapted such that, in a vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; and a power supply disposed within the housing and adapted to power the vibrating agitation mechanism; (b) ingesting the capsule, by the subject; and (c) controlling the vibrating agitation mechanism such that at least a portion of the vibrating mode of operation occurs within the stomach and/or the small intestine of the subject.

A system for monitoring a joint of a patient includes multiple sensors to be disposed near a joint and to measure or observe actions or physical quantities associated with the joint; and at least one communications module coupled to the sensors to receive data from the sensors and to transmit sensor information to an external device. The system also includes a patient device and clinician device which can be used to, for example, monitor and display information obtained from the sensors, determine range of motion measurements from the sensor data, show progress in physical therapy, take a photograph or video of the site on the patient, obtain a pain score, and include friends for providing encouragement during physical therapy.

Provided herein are compositions for the ingestible administration of lisinopril. In some embodiments the compositions comprise lisinopril and silicon. In some embodiments, the compositions comprise lisinopril, silicon, magnesium metal, and copper (I) chloride. Also provided herein are apparatuses comprising the compositions provided herein. Also provided herein are methods for using the compositions and apparatuses provided herein.

Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

Example implants, systems and methods using sensors for orthopedic surgical assessment and/or planning are described herein. An example system can include a wearable sensor device for pre-operative use by a patient before an orthopedic surgery to generate pre-operative sensor data. The system can also include an implantable sensor device (e.g., a bone implant) to generate and aggregate post-operative sensor data associated with the patient after the surgery. The system can retrieve the pre-operative sensor data and the post-operative sensor data and predict, analyze or assess an outcome of the surgery.

A measurement device suitable to measure a force, pressure, or load applied by the muscular-skeletal system is disclosed. The measurement module includes a unitary circuit board that couples electronic circuitry to sensors. In one embodiment, the sensors are integrated in the unitary circuit board. Using more than one sensor allows the position of applied load by the muscular-skeletal system to be measured. In one embodiment, the sensors of a sensor array can be elastically compressible capacitors. A load plate can underlie the sensor array. Similarly, a load plate can overlie the load plate. Load plates are rigid structures for distributing a force, pressure, or load. The measurement device can include an articular surface for allowing movement of the muscular-skeletal system. A remote system can be in proximity to the measurement device. The remote system can receive, process, and display data from the measurement module in real-time.

The current disclosure relates to methods and devices for measuring concentrations of analytes in the gastrointestinal tract of a subject by orally administering a smart pill to the subject, the smart pill comprising two or more sensors, a reference electrode, a power source, a communication interface and electronic circuits, each sensor being able to measure an analyte in the gastrointestinal tract of said subject, wherein the two or more sensors measure different analytes, measuring a concentration of two or more analytes using the two or more sensors, wherein one of the sensors is a pH sensor for measuring hydrogen ions, and wherein the pH sensor is able to locate the smart pill in the gastrointestinal tract by correlating the measured hydrogen ion concentration to a location in the gastrointestinal tract, and transmitting, using the communication interface, the measured concentrations from the two or more sensors to a base device located outside of the body of the subject.

Disclosed are systems and methods for detecting analyte levels. These systems and methods may include a sensor configured for at least partial placement in an analyte-containing medium. The sensor may include one or more transducers and one or more diffusion barriers. The diffusion barriers may be arranged to delay diffusion of analyte to one transducer relative to another transducer. This delay may be used for purposes such as calculating and/or compensating for lag between a measured analyte level and a physiological analyte level of interest.

A noise-separating cardiac monitor is provided. An implantable housing includes an external surface. A wireless antenna is shaped to wrap around an interior periphery of the implantable housing. Electrodes are provided on a ventral surface of the implantable housing to capture P-wave signals and R-wave signals. Electronic circuitry is provided within the wearable housing and includes a low power microcontroller. A front end circuit includes a signal lead operable to sense cardiac electrical potentials through one of the electrodes, a reference lead operable to sense the cardiac electrical potentials through another electrode, and a reference generator configured to inject a driven reference to the reference lead. The signal lead includes a coupling capacitor and a protection resistor associated with thermal noise. The thermal noise is not contained in the driven reference and not introduced to the reference lead. A non-volatile memory is electrically interfaced with the microcontroller.

A system and method for collecting operation data associated with a medical apparatus including an internal device implanted in a subject and an external device that is magnetically-coupled to and drives the internal device. The medical apparatus may be monitored to obtain raw data associated with the operation of the medical apparatus and one or more calculations may be performed on the raw data, wherein the raw data and/or calculated values may be associated with voiding frequency and voiding volume of the subject. A report may be generated from the raw data and/or calculated values. In addition, one or more signals may be sent to the external device and/or a docking station, or communicated by other means, to indicate to the subject that the operation of the medical apparatus should be altered.