A prosthetic component suitable for long-term implantation is provided. The prosthetic component measures a parameter of the muscular-skeletal system is disclosed. The prosthetic component comprises a first structure having at least one support surface, a second structure having at least one feature configured to couple to bone, and at least one sensor. The prosthetic component is a housing for the at least one sensor and electronic circuitry. The electronic circuitry is hermetically sealed from an external environment. The at least one sensor couples to the support surface of the first structure. The support surface of the first structure is compliant. The first and second structure are coupled together housing the at least one sensor and electronic circuitry.

Embodiments of the present disclosure relate to implantable medical devices (IMDs). In an exemplary embodiment, an IMD comprises: a housing including a plurality of feedthroughs extending through the housing, a first electrode, a second electrode, and a biocompatible circuit board disposed around an outer surface of the housing. The biocompatible circuit board comprising a plurality of traces, wherein a first trace of the plurality of traces is coupled to the first electrode and a first feedthrough of the plurality of feedthroughs, and a second trace of the plurality of traces is coupled to the first electrode and a second feedthrough of the plurality of feedthroughs.

Embodiments herein include systems and methods for detecting, predicting and/or assessing acute kidney injury. In an embodiment, a monitoring system to detect acute kidney injury is included. The monitoring system can include a sensor circuit configured to collect renal data including at least one of systemic renal data, direct renal data, urinary tract data, and renal-relevant extracorporeal data. The monitoring system can also include a memory circuit to store collected renal data, an evaluation circuit to assess renal status, and a telemetry circuit. The evaluation circuit can determine whether acute kidney injury has occurred or is likely to occur by comparing the renal data to at least one of threshold values, personal historical values, patient population values and patterns indicative of acute kidney injury. The evaluation circuit can initiate a warning notification if acute kidney injury has occurred or is likely to occur. Other embodiments are also included herein.

Enzymatic and non-enzymatic detectors and associated membrane apparatus, and methods of use, such as within a fully implantable sensor apparatus. In one embodiment, detector performance is controlled through selective use of membrane configurations and enzyme region shapes, which enable accurate detection of blood glucose level within the solid tissue of the living host for extended periods of time. Isolation between the host's tissue and the underlying enzymes and reaction byproducts used in the detectors is also advantageously maintained in one embodiment via use of a non-enzyme containing permeable membrane formed of e.g., a biocompatible crosslinked protein-based material. Control of response range and/or rate in some embodiments also permits customization of sensor elements. In one variant, heterogeneous detector elements are used to, e.g., accommodate a wider range of blood glucose concentration within the host. Methods of manufacturing the membranes and detectors, including methods to increase reliability, are also disclosed.

A miniaturized medical device comprises an electronic functional device for performing a function of said miniaturized medical device. The miniaturized medical device further comprises a wake-up device for transferring said functional device from a switched-off state to an operational state. Herein, the wake-up device comprises an electrical detection circuit configured to generate a wake-up signal and a switch device. The switch device comprises a switch member, a magnet device attached to the switch member and at least one switch contact. The switch member is excitable by a time-varying magnetic field to perform an oscillating movement for acting onto said at least one switch contact to perform a switching action of the switching device in the electrical detection circuit and to in this way generate the wake-up signal.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Modules, systems and methods for clearing substances from a living body are disclosed. A module may include an instructions receiver configured to receive wireless transmissions of instructions from a master controller located outside of the body when the module is inside the body; an energy receiver configured to receive wireless transmission of non-destructive energy from the master controller located outside of the body when the module is inside the body; an energy converter configured to convert the non-destructive energy received to destructive energy; and an energy emitter configured to emit the destructive energy.

An apparatus and method apply magnetic fields by generators external to a body or body part with sensors within an in vivo source that are sensitive to applied magnetic fields Through the use of these applied magnetic fields and sensitive sensors, disclosed embodiments can realize much better spatial resolution than is conventionally possible.

A system and method is outlined for a wearable external device that communicates with a fully implantable miniaturized biosensor platform providing fast spatial detection and accurate assessment of the position and orientation of the implant within highly scattering tissue. The device and method provides spatial (x, y) position, depth (z) and rotational (φ) state of the implantable biosensor platform. The spatial (x, y) position allows the ability to turn-on only one out of an entire array of LEDs that is in line-of-sight with the implant in order to conserve power. Similarly, the depth and rotational coordinates information is used to adjust the output light intensity of the selected light emitters to compensate the power delivered to the implant. The above attributes render the system compatible for usage during intense physical activity and for added user comfort through improved skin ventilation.

A medical implant including an implant body for insertion into a human and/or animal body. The implant body includes at least one first and at least one second contact portion, wherein the at least one first and the at least one second contact portions contact two tissue regions performing a relative movement with respect to one another. The at least one first and the at least one second contact portions are movable relative to one another, wherein a relative movement of the contact portions may be converted into an electrical signal.