A timing unit and method useable with a computer and user input includes a circuit and a timer. The timer establishes a reference signal having periodic occurrence and receives a trigger signal from the user input. The circuit generates information that represents the periodic occurrences of the reference signal and response timing data representing a relationship between the trigger signal and one of the occurrences. A communication channel is provided between the circuit and the computer.

Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

An ocular cranial nerve monitoring system (OCNMS) that provides continuous measurement of pupillary reactivity in the eye. The system features a sensor component that produces a stimulating light and a recording light and records reflected recording light so as to calculate pupillary diameter and response to stimulation as measured by latency, velocity, and/or amplitude. This system of the present invention may be used for indirect assessment of the 2nd and 3rd cranial nerve (CN 2, CN3) pathways and/or intracranial pressure in patients and may be used intraoperatively. The data obtained from this system may allow for immediate corrective actions, which may help prevent permanent deficits and improve patient safety and surgical outcomes. In some instances, the system may help avoid unnecessary or invasive procedures (e.g., catheters inserted for intracranial pressure monitoring).

Methods for treating a human patient diagnosed with cancer with therapeutic neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological processes associated with the progression of cancer. One aspect of the present technology is directed to methods that attenuate neural traffic along target sympathetic nerves innervating tissue proximate a primary malignant tumor. Other aspects are directed to methods that at least partially inhibit sympathetic neural activity in a renal nerve of a patient diagnosed with cancer or who has a high risk of developing cancer. Targeted sympathetic nerve activity can be attenuated to improve a measurable physiological parameter corresponding to the progression of cancer in the patient. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.

A time series of image data is provided to a computer as the basis for performing an ICA to identify a number of candidate correlation patterns. The number of candidate correlation patterns includes a number of neurophysical events and false patterns due to noise. This is followed by a differentiation in the computer between the neurophysical events and the false patterns, for example based on a metric, which indicates the intensity of the candidate correlation patterns in a sub-region of the brain, or by a computer-implemented classifier. Such techniques can be used in conjunction with functional magnetic-resonance imaging.

A wearable system for use by a user includes a photodetector configured to detect a photon of a light pulse after the photon reflects from a target internal to the user. The photodetector includes a single photon avalanche diode (SPAD) and a capacitor configured to be charged, while the SPAD is in a disarmed state, with a bias voltage by a voltage source, and supply, when the SPAD is put in an armed state, the bias voltage to an output node of the SPAD such that a voltage across the SPAD is greater than a breakdown voltage of the SPAD.

A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.

Concepts presented herein relate to an interface module that can be electrically coupled to an electrical stimulation generator, a radio frequency generator and an instrument. A selection module is coupled to the interface module and operates in a first mode to deliver electrical stimulation signals from the electrical stimulation generator to the instrument and in a second mode to deliver radio frequency signals from the radio frequency generator to the instrument.

Systems, devices, and methods for neurostimulation using a combination of implantable and external devices to treat pain are disclosed.

A device for monitoring eye movement and pupil response that comprises a first optical pathway for displaying one or more images to the eyes of a patient and a second optical pathway for obtaining images of the eyes of a patient. The device further comprises at least one screen for displaying an image to the left eye of the patient which is not visible to the right eye of the patient and for displaying an image to the right eye of the patient which is not visible to the left eye of the patient; a first camera for capturing images of the left eye of the patient; and a second camera for capturing images of the right eye of the patient at substantially the same time as the first camera is capturing images of the left eye of the patient. The device also comprises at least one IR light source for illuminating the eyes of the patient; and a processor for processing the obtained images and measuring pupil response and/or eye movements.