A device for measuring a neural response evoked by a stimulus. First and second sense electrodes are positioned at distinct locations along a neural pathway. A neural stimulus is applied and first and second recordings of a neural response evoked by the stimulus are obtained from the respective sense electrodes. The first recording and the second recording are compared to determine propagation properties of the evoked neural response.

A system and method for adaptive illumination, the imaging system comprising an excitation source having a modulator, which generates a pulse intensity pattern having a first wavelength when the excitation source receives a modulation pattern. The modulation pattern is a data sequence of a structural image of a sample. An amplifier of the imaging system is configured to receive and amplify the pulse intensity pattern from the modulator. A frequency shift mechanism of the imaging system shifts the first wavelength of the pulse intensity pattern to a second wavelength. A laser scanning microscope of the imaging system receives the pulse intensity pattern having the second wavelength.

A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell.

The techniques of the disclosure describe example medical devices, systems, and methods for delivering stimulation therapy comprising a first set of a plurality of pulses having a first amplitude, and a second set of a plurality of pulses having a second amplitude greater than the first amplitude. The second amplitude is adjusted to an adjusted second amplitude based on second amplitude being less than or greater than activation threshold. The first amplitude is adjusted based on adjusted second amplitude, and therapy is delivered based at least one the adjusted first amplitude.

The subject matter of the present disclosure generally relates to techniques for neuromodulation of tissue that include applying energy (e.g., electromagnetic energy) into the target tissue to cause altered activity of a neuron in the tissue. In certain embodiments, the altered activity causes a change in one or molecules in the tissue or blood.

The techniques described herein are example medical devices, systems, and methods for sensing evoked potentials in a tissue of the patient, and, based on the sensed evoked potentials, adjusting one or more parameters defining the electrical stimulation therapy delivered to the patient. In one example, a system controls delivery of an electrical stimulation therapy from an implantable medical device to a patient according to at least one therapy program, wherein the electrical stimulation therapy is configured to provide pain relief to the patient without substantially resulting in paresthesia perceived by the patient. The system periodically adjusts the electrical stimulation therapy delivered to the patient in response to detected compound action potentials, wherein the adjustment to the electrical stimulation therapy is configured to eliminate action potentials in tissue of the patient evoked by the delivered electrical stimulation, and wherein the controlling and the adjusting are performed via one or more processors.

Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including a head mounted display to monitor one or more physiologic signals from the face or head of the subject is disclosed. A method for analyzing an ocular parameter of the subject to determine a sympathetic and a parasympathetic outflow thereto is disclosed.

A microelectrode array comprises three or more flexible oblong, electrically co-operating microelectrodes in wire and/or ribbon form disposed substantially in parallel. The microelectrodes are electrically insulated except for at a distal section thereof. The array further comprises electrically non-conducting microfibres connecting central portions of the microelectrodes in oblique directions in respect of the array axis. In a preferred array variety the microelectrodes are joined by a glue that is dissolvable or degradable in aqueous body fluid. Also disclosed is a combination of two or more arrays of the invention.

An anesthetic syringe comprising a nerve detector and an illuminated indicator. The nerve detector is configured to receive a radiative energy from a nerve in a tissue and send a signal to the illuminated indicator. The illuminated indicator shows a direction to move the syringe to a tissue location proximal to the nerve for injecting a local anesthetic drug. The syringe may accommodate a standard drug cartridge and may provide manual or automatic movement of a plunger.