This invention relates the use of cortisol blockers (glucocorticoid receptor [GR] antagonists) for the treating or preventing treatment resistant prostate cancer, treating or preventing neoplasia, and treating or preventing infection related to acute or chronic injury or disease.

A combined wine glass and wine bottle package includes a wine glass constructed from molded plastic with an upper shell-shaped body defining an upwardly narrowing tapered flume of generally uniform thickness and a contoured lower base defining an annular moat surrounding a central punt. A wine bottle is sized to fit substantially into the wine glass in an inverted orientation with a removable bottle cap nested within the central punt, and with an upper rim of the wine bottle snap-fitted into a shallow groove formed in the wine bottle near a lower end thereof. This entire package is sterile-wrapped in a sealed shrink-wrap plastic or the like. The package can be opened when desired to permit removal of the wine bottle from the wine glass, following by bottle opening and pouring of the contents into the wine glass.

This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy utilizing a GCR antagonist, such as ORG 34517. The rapid, sensitive, and inexpensive test can be used to determine patients who have non-normal cortisol production or disordered circadian rhythms as a method for selecting subjects for GCR antagonist therapy for whom it is likely to have beneficial and/or therapeutic effects, and can also be used to monitor changes in cortisol levels in response to treatment.

A packaging system including a heat shrinkable flexible wall container and a heat shrinkable label is described. The label can be applied to the container prior to heat shrinking. Upon subjecting the labeled container containing the items or goods of interest to a heat shrink operation, the label and flexible wall container both undergo shrinking. The shrinkage characteristics of the flexible wall container and the label are matched to one another. Also described are various methods of packaging using the noted systems.

The invention relates to a film product (10) for packing products, particularly liquids (200), pasty and/or pourable materials, in sealed film packages (100), comprising at least two film layers (20a, 20b), wherein the outwardly facing film layer (20a) is thermally stable, and the inwardly facing film layer (20b) is sealable, and both film layers (20a, 20b) are produced in a water-cooled coextrusion blow molding process.

The invention relates to improvements in or relating to the packaging of food 36 between a first plastic film 16 and a second plastic film 18 using a packaging apparatus 10. A tray 24 is formed from the first plastic film 16, the tray having a floor 33 with at least one channel 32. An absorbent pad 34 is provided on the floor 33 of the tray 24. A portion of food 36 is provided on the floor 33 of the tray 24. The second plastic film 18 is placed on the tray 24 to sandwich the absorbent pad 34 and the portion of food 36 between the plastic films 16, 18. The packaging apparatus 10 is operated to urge the two plastic films 16, 18 together and to create a seal therebetween. At least one duct 76 is formed between said at least one channel 32 and at least one of the second plastic film 18, the absorbent pad 34, and the portion of food 36.

A self-standing container for holding and pre-soaking a cooking plank in a soaking liquid includes flexible walls forming a bag-like container with a chamber to receive the plank and the liquid. The container includes a deployable standing structure to enable the container to be placed in an upright position to conserve counter space. The container with a plank and liquid may be packaged for retail sale and later reuse.

A storage bag includes first and second sidewalls having a top edge, a top portion, and a bottom portion. The bottom portion of the first sidewall includes at least one shift region about which the bag is capable of shifting. The shift region includes a score line, an indentation, or a crimp formed into the first sidewall. The top portions of the sidewalls include a cuff region includes a textured patterned band to provide a visual cue to a user as to where to fold and to cuff the bag. The bag shifts between (i) a flat configuration with the sidewalls positioned adjacent to each other, and (ii) a stand-up configuration with the sidewalls separated from each other. In the stand-up configuration, the bag has a substantially flat base. The cuff region can be shifted to a cuffed position with the cuff region forming the opening to the bag.

The invention provides a heat shrinkable polyester film which has (1) a hot-water heat shrinkage of not less than 55% and not more than 90% in a main shrinking direction of the film when dipped in hot water at 98 C.; (2) a hot-water heat shrinkage of not less than 5% and not more than 12% in a direction orthogonal to the main shrinking direction of the film when dipped in hot water at 98 C.; (3) a difference in specific heat capacity C.sub.p between at a lower and a higher temperature than Tg of not less than 0.1 J/(g.Math. C.) and not more than 0.7 J/(g.Math. C.) when a reverse heat flow is measured with a temperature modulated DSC; and (4) a tensile breaking strength of not less than 70 MPa and not more than 150 MPa in the direction orthogonal to the main shrinking direction of the film.

The combination package includes a beverage glass having an upper shell-shaped body defining an upwardly narrowing tapered flume of generally uniform thickness terminating in a smooth upper rim thereof defining an open mouth, and a lower base opposite the open mouth; and a bottle defining a container for retaining a beverage and a pour spout for dispensing the beverage therefrom, the bottle having a size and shape for select slide-in reception through the open mouth of the beverage glass in an inverted orientation such that the upwardly narrowing tapered flume selectively engages a sidewall of the container for friction-fit engagement therewith, wherein engagement of the bottle with the beverage glass forms the combination package.