Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.

An attachment for a device for generating an air flow or dispensing a fluid, which attachment is designed to be at least partially introduced into an external auditory canal of a human or animal ear, the attachment including a connection piece for connecting the attachment to the device for generating an air flow, and a tongue-type guide vane for conducting air that flows out of the device for generating an air flow via the connection piece, the guide vane having a bottom.

A temperature-controlled massage node that imparts either or both a heating or cooling effects is provided, which may be attached to a massager to impart a heating or cooling effect on a user with a massage effect, or optionally, without a massage effect. The temperature-controlled massage node may be affixed to the massager or may be removably coupled. The temperature-controlled massage node may be powered by the same power source as the massager or may include an independent power source located, for example, in the massage node. The massage node may be used with a massager that provides percussive massage effects, such as a massage gun, or may be used with a vibrating massager. Optionally, the massage node may include independent power, a controller and a motor to supply both a vibrating massage effect and hot and cold effect, either alone or in combination.

A temperature-controlled massage node that imparts either or both a heating or cooling effects is provided, which may be attached to a massager to impart a heating or cooling effect on a user with a massage effect, or optionally, without a massage effect. The temperature-controlled massage node may be affixed to the massager or may be removably coupled. The temperature-controlled massage node may be powered by the same power source as the massager or may include an independent power source located, for example, in the massage node. The massage node may be used with a massager that provides percussive massage effects, such as a massage gun, or may be used with a vibrating massager. Optionally, the massage node may include independent power, a controller and a motor to supply both a vibrating massage effect and hot and cold effect, either alone or in combination.

A cryolipolysis applicator including a receptacle made of a wall and including an opening bordered by the wall, the receptacle defining a cavity, the applicator including a pipe leading into the cavity and able to be connected to a suction system which is capable of sucking a fat fold into the cavity. The wall is made of an inner shell and of an outer shell surrounding the inner shell, the space between the inner shell and the outer shell being sealed shut with the exception of an inlet port and an outlet port, the inlet port and outlet port being connected by a circuit which extends within the space, the circuit being able to receive a cooling fluid.

The present invention generally relates to improved medical devices, systems, and methods, with exemplary embodiments providing improved cooling treatment probes and cooling treatment methods and systems. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling of the skin of the patient during a cooling treatment. Additionally, embodiments may limit adverse side effects such as hyperpigmentation. It has been found that the freezing behavior (frequency and time to freeze) can be modified by adjusting the thermal parameters of the cooling applicator. Accordingly, in some aspects of the invention, a method of treating the skin may be provided where the thermal parameters of the cooling applicator are adjusted during treatment.

The present invention relates to a pen for the treatment of dermatological disorders, such as warts and the like, by means of a coolant. The pen includes a distal part having a holder for the storage of a coolant and a proximal part with an applicator for the administration of the coolant to the dermatological surface for treatment. These parts extend axially and are in coolant communication by means of a coolant passage in the proximal part, in which a valve body is provided for closing off and/or opening the passage. The passage is provided with at least one bypass for the coolant. In addition, the invention relates to a method for the administration of the pen.

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

A device (1, 20, 100, 200) to treat vaginal atrophy comprising a treatment module (2, 21, 101, 201) configured for insertion into the vagina and having a microtrauma module. The micro trauma module is configured to deliver negative pressure mechanical microtrauma therapy to a wall of the vagina when inserted. The microtrauma module comprises a plurality of apertures (6, 106, 206) in fluidic connection with a vacuum pump, the device being arranged to generate a negative pressure at the apertures (6, 106).