A method is provided for treating a gland or duct of a patient. In a particular embodiment, an obstruction in a gland or duct and the orifice thereof can be alleviated; in another, a substance can be injected thereinto; in yet another, the gland can be aspirated. The method includes the step of inserting an elongated6 probe into a gland or duct via an orifice thereinto. In some embodiments the probe can have a longitudinal lumen therethrough, with at least one distal hole through the probe wall in fluid communication with the lumen. The lumen can be used in concert with a source of suction for removing debris from the gland or duct, and/or with a source of a fluid and pumping means, for injecting a substance into the gland or duct.

This disclosure relates to a cap assembly for a medicament delivery device that has a cap body arranged to be connected to a medicament delivery device for protecting and for removing a medicament delivery member shield. The cap body has an inner cap structure defining a channel extending along the central axis of the cap body, and a gripping member configured to be received in the channel with a friction fit and to receive a medicament delivery member shield. The gripping member has a first leg, a second leg, and a transverse portion extending between the first leg and the second leg, which transverse portion defines the leading edge of the gripping member when received by the channel.

The disclosure relates to medical databases, remote monitoring, diagnosis and treatment systems and methods. In one particular embodiment, a system for remote monitoring, diagnosis, or treatment of eye conditions, disorders and diseases is provided. This method generally includes administering a stream of droplets to the eye of a subject from an ejector device, and storing data related to the administration in a memory of the ejector device. The data may then be monitored and analyzed.

Systems and methods for removing a preservative from a solution, emulsion, or suspension may include an ophthalmic agent, a complexing agent, and a matrix. A method for administering an ophthalmic agent may include: providing a solution, emulsion, or suspension comprising a hydrophobic ophthalmic agent, a preservative, and a complexing agent, wherein the complexing agent is configured to host the hydrophobic ophthalmic agent; and providing a polymeric matrix, wherein the complexing agent is configured to reduce an affinity of the ophthalmic agent for the polymeric matrix and wherein the polymeric matrix is configured to selectively absorb the preservative when the solution, emulsion, or suspension is passed therethrough.

The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.

An activation assembly for a medicament delivery device is presented having a delivery member cover provided with legs and configured to be biased in a proximal direction, a movable sleeve configured to be received between the legs, and an activation sleeve configured to be biased in the proximal direction, wherein the delivery member cover is configured to be moved in an axial direction between a first position and a second position, wherein movement of the delivery member cover from the first position to the second position causes movement of the movable sleeve from a first movable sleeve position to a second movable sleeve position. The delivery member cover axially displaces the activation sleeve in a distal direction when the delivery member cover moves towards the second position, thereby causing a first actuation of a sensor. The activation sleeve is configured to move in the proximal direction when the delivery member cover returns from the second position to the first position, thereby providing a second actuation of the sensor.

A method and assembly for attaching to a container and configured to reduce the volume of a droplet of fluid ejected from the container wherein the assembly is securable to the container without alteration of the container and wherein the volume of the droplet is reduced on a microliter scale. The assembly comprises a base for securing a neck of the container; a tip for securing over a dispensing outlet of the container; and optionally a cap for securing over the tip and connecting to the base.

The present disclosure is directed to compositions comprising oxymetazoline and methods of stabilizing oxymetazoline compositions for long term storage.

An applicator for ophthalmic solutions in single-dose containers includes a structure, an oval rim, a container attachment portion, a hollow and flat support base, and additional features. The structure with open spaces is for inserting, removing, and pressing the single-dose container and allowing the label and the contents of the container to be viewed. The oval rim has a concave upper lip and a concave lower lip to facilitate the positioning of the applicator at an angle between 30 and 60° with respect to a horizontal plane. The features of the applicator enable the device to be used easily, ergonomically, comfortably, and ensure a safe use of the single-dose container in applications after the first use.

Some embodiments disclosed herein relate to devices and methods for controlling placement of intraocular implants within a patient's eye including but not limited to placement within or near the collector ducts of Schlemm's canal located behind the trabecular meshwork. In some embodiments, a handheld peristaltic rotor device having a compression element can be positioned on a corneal surface of the eye and rotated to create a peristaltic movement of blood in one or more episcleral veins to generate blood reflux within Schlemm's canal such that one or more collector ducts, or channels, of Schlemm's canal can be located. In some embodiments, an implant can be implanted near the identified location of the one or more collector ducts, or channels.