A system for subatmospheric pressure therapy in connection with healing a wound is provided. The system includes a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source. The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent conduit in fluid communication with the collection canister and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit.

Disclosed embodiments relate to apparatuses and methods for a skin perfusion pressure determination device. In some embodiments, a skin perfusion pressure determination device can include a sensor module having a first sensor for sensing a first parameter associated with a pressure exerted on a target area by the sensor module and a second sensor for sensing a second parameter associated with an amount of blood perfusion at the target area. In some embodiments, the first sensor and the second sensor can be arranged such that, when the sensor module is pressed against the target area the first sensor produces an output corresponding to the sensed first parameter and the second sensor produces an output corresponding to the sensed second parameter.

A wound dressing is disclosed. A wound dressing comprises a first adhesive layer, an electrode assembly, a monitor interface and a multiplexer. The first adhesive layer comprises a proximal surface configured for attachment of the wound dressing to a skin surface of a user. The electrode assembly comprises a plurality of electrodes including a first set of first electrodes. The monitor interface is configured to form a mechanical and electrical connection with a monitor device. The monitor interface comprises a coupling part and a plurality of terminals including a first terminal. The multiplexer comprises a number of N input pins and a number of M output pins. The N input pins include a first set of first input pins for connection to first electrodes of the first set of first electrodes, the first set of first pins including a first primary input pin and a first secondary input pin, and the M output pins include a first output pin. The first primary input pin is connected to a first primary electrode of the first set of first electrodes and the first secondary input pin is connected to a first secondary electrode of the first set of first electrodes, and the first output pin is connected to the first terminal of the monitor interface. The multiplexer is configured to connect the first primary input pin to the first output pin in a first multiplexer configuration and to connect the first secondary input pin to the first output pin in a second multiplexer configuration.

A natural peptide comprising a cellular growth promoting fragment of a protein selected from SEQ ID NO's: 1 to 13, and a composition comprising a plurality of growth promoting peptides, is described. Also disclosed is the use of the peptides and compositions in prevention of ageing of human skin, treatment of diseases or conditions characterised by damaged epithelial cells or tissue such as colon cancer and peripheral inflammatory disorders, and wound treatment. Specific pea and rice protein derived peptides are described in SEQ ID NO's: 15 to 505, and 546 to 704.

The invention relates to an absorbent dressing comprising an adhesive silicone-coated side strip, which is particularly suitable for use in the care of chronic wounds, such as ulcers or eschars, or acute wounds, such as burns. The absorbent dressing includes a breathable impermeable substrate (4) and an absorbent non-woven fabric (6). The substrate is formed by assembling a continuous film (4a) and an openwork reinforcement that is coated with an adhesive silicone gel (4b) without blocking the openings in the reinforcement. A non-absorbent web (5) is secured to a complementary non-woven fabric (7), such as to encase the above-mentioned absorbent non-woven fabric (6) without being secured at any point to the latter. The encased absorbent non-woven fabric is subsequently assembled to the substrate (4) along part of said silicone-coated surface of the substrate.

A wound dressing for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies, includes an active ingredient, such as collagenase, which serves to debride wounds in-situ. In one example, purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.

The invention relates to a wound dressing for placement on a wound located on a skin surface with an electrode arrangement for forming a dielectric barrier plasma discharge by way of at least one electrode that can be supplied with a high AC voltage and is completely embedded in a flat dielectric, wherein the dielectric forms a wound-side application side and the electrode has intermediate spaces dispersed across its surface that are aligned with passage openings of the dielectric, the passage openings of the dielectric having smaller dimensions than the intermediate spaces of the electrode, so that the dielectric also completely covers the electrode in the area of the passage openings and extends from the wound-side application side to a rear side of the dielectric opposite the wound-side application side and is permeable to a fluid, characterized in that a fluid absorption layer for absorbing a fluid conducted through the passage openings of the dielectric from the wound-side application side to the rear side, which has a super-absorber or consists of such a super-absorber, rests against the opposite rear side of the dielectric.

A bacteria-responsive color-changing, core-shell nanofiber, comprising polyurethane (PU), a hemicyanine-based chromogenic probe localized in the core-shell nanofiber near the surface of the shell, polyvinylpyrrolidone (PVP) dopant in the shell, the hemicyanine-based chromogenic probe further comprising a labile ester linkage that is enzymatically cleavable by bacterial lipase released from clinically relevant strains of bacteria including Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA).

An adhesive bandage having a backing material and a hydrocolloid pad disposed thereon effectively removes wound exudate while enabling facile removal. The bandage includes a backing material comprising a sheet having an adhesive layer disposed thereon having a first color. The hydrocolloid pad has an absorbency (24 hr) of between about 2 and about 6 g/g, and includes a hydrocolloid layer forming a first surface thereof and a polymeric film layer having a second color associated therewith different than the first color of the backing material forming a second surface thereof. The hydrocolloid pad is disposed in facing relation and adhered to the adhesive layer of backing material. The first surface having a dry peel strength of between about 0 and about 700 gf, a wet peel strength of between about 0 and 150 gf.

This invention describes a wound dressing product for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies. The present invention pertains to the principle of continuous wound debridement which makes necrotic tissue more susceptible for removal and hence enhances progressive wound healing. The dressing contains an active ingredient, such as collagenase which serves to debride wounds in-situ. In the present invention purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.