Ultrafine bubbles with a diameter of less than 1.0 μm are generated in liquid by causing film boiling in liquid by means of a heater.

An ultrafine bubble generating apparatus and an ultrafine bubble generating method capable of efficiently generating an ultrafine bubble-containing liquid with high purity are provided. In order to this, a heating element provided in a liquid is caused to generate heat, and film boiling is made on an interface between the liquid and the heating element. A film boiling bubble is generated by the film boiling, and ultrafine bubbles are thus generated near the film boiling bubble.

In order to efficiently produce a liquid containing ultrafine bubbles of a desired gas, an ultrafine bubble-containing liquid producing apparatus includes a gas dissolving unit that dissolves a predetermined gas into a liquid, and a UFB generating unit that generates ultrafine bubbles in the liquid in which the predetermined gas is dissolved. A CPU performs control under a first condition in a case of causing the gas dissolving unit to operate in a circulation route passing through the dissolving unit. The CPU performs control under a second condition different from the first condition in a case of causing the UFB generating unit to operate in a circulation route passing through the UFB generating unit.

A method for reducing sequencing by synthesis cycle time using a microfluidic device is provided. The microfluidic device comprises a flow cell having an inlet port, an outlet port, and a flow channel extending between the inlet port and the outlet port, wherein the flow channel receives an analyte of interest and one or more reagents for analyzing and detecting molecules. To aid in the acceleration of the reactions, the microfluidic device comprises a mixing device to increase the rates of diffusion of the reagents from the fluid bulk to an active surface of the flow cell. The mixing device comprises at least one of an electrothermal mixing device, an active mechanical mixing device, and a vibrational mixing device.

The invention is an apparatus for mixing and moving small fluid samples including a microfluidic chip with a fluid flow channel and an injection port, a channel light beam with a channel lens configured to converge a channel light beam and project a channel light beam focal spot into the fluid flow channel;

Provided is a method of producing an ultrafine bubble-containing liquid containing ultrafine bubbles generated by causing film boiling in a liquid with a heat generation member, including: detaching a solid present at a liquid contact surface of the heat generation member in a form of a microscopic substance by using the film boiling; and generating ultrafine bubbles with the detached microscopic substance as a core.

Described herein are systems relating to a continuous-flow instrument that includes all necessary components for digital droplet quantification without the need to introduce key reagents or collect and transfer droplets between stages of instrument operation. Digital quantification can proceed without any additional fluid or consumable handling and without exposing fluids to risk of external contamination.

Described herein are systems relating to a continuous-flow instrument that includes all necessary components for digital droplet quantification without the need to introduce key reagents or collect and transfer droplets between stages of instrument operation. Digital quantification can proceed without any additional fluid or consumable handling and without exposing fluids to risk of external contamination.

Described herein are systems relating to a continuous-flow instrument that includes all necessary components for digital droplet quantification without the need to introduce key reagents or collect and transfer droplets between stages of instrument operation. Digital quantification can proceed without any additional fluid or consumable handling and without exposing fluids to risk of external contamination.

Provided are a method for producing an ultra-fine bubble-containing liquid, an ultra-fine bubble-containing liquid, and a method for utilizing and a device for utilizing ultra-fine bubbles that allow highly concentrated UFBs to be maintained for a long period of time and that are capable of effectively utilizing the UFBs. To this end, the method for producing an ultra-fine bubble-containing liquid includes an ultra-fine bubble generating step and a dispersing step to disperse the ultra-fine bubbles. In the ultra-fine bubble generating step, the ultra-fine bubbles are generated in a liquid by heating a heating element and making film boiling on an interface between the liquid and the heating element. In the dispersing step, a floc, which includes two or more ultra-fine bubbles, is dispersed into multiple ultra-fine bubbles by applying vibration to the liquid in which the floc floats.