A system for processing a sample includes a unitary body. The unitary body including a snap lid, the snap lid having a capillary. The unitary body including a lysing container. The unitary body including a test element and a sliding actuator.

Provided herein are methods of amplifying and detecting biothreat pathogens in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).

The present invention aims to provide a fluid handling device which can be manufactured more conveniently, can easily open and close a channel, and can be miniaturized. The fluid handling device of the present invention includes: a first channel; a second channel; and a valve disposed between the first channel and the second channel, in which the valve includes: a groove-shaped valve seat disposed in a board, and a flat plate-shaped flexible layer covering the groove-shaped valve seat, and the valve communicates between the first channel and the second channel when the flat plate-shaped flexible layer and a bottom of the groove-shaped valve seat are spaced apart from each other, and blocks communication between the first channel and the second channel when the flat plate-shaped flexible layer and an inner wall of the groove-shaped valve seat are in contact with each other.

Systems and methods for detecting the presence of a target nucleic acid in a sample via a recombinase polymerase amplification (RPA) reaction followed by a FEN1 cleavage detection reaction are disclosed. One aspect of the present disclosure relates to systems involving a sample collection device for collecting a sample and performing an RPA reaction on the sample, followed by the detection of the amplified product via a two-step FEN1 cleavage detection reaction which generates a fluorescent signal indicative of the presence of amplified product.

A system for generating data relating to a tissue core comprises a core needle biopsy module configured to obtain a tissue core from a locus within the body, and a tissue disintegration module operably connected to the core needle biopsy module and configured to receive a tissue core from the core needle biopsy module and convert at least a portion of the tissue core into gaseous tissue molecules. The system also comprises first vacuum pump means configured to convey a tissue core from the needle biopsy module to the tissue disintegration module, and second vacuum pump means configured to convey gaseous tissue molecules from the tissue disintegration module to an analyser module.

The disclosure relates to a method for pretreating a sample for metals determination. The method includes: providing an aqueous sample mixture comprising a sample containing or suspected of containing one or more metals for detection; contacting the aqueous sample mixture with a first electrode (anode) comprising electrically conducting boron-doped diamond (BDD); electrically contacting the aqueous sample mixture with a second electrode (cathode); applying an electrical potential between the first electrode and the second electrode (i) to provide an electrical current therebetween and through the aqueous sample mixture, (ii) to generate hydroxyl ion (OH.sup.−) species at the first electrode, (iii) to oxidize and free the one or more metals for detection in the sample, thereby forming a pretreated aqueous sample comprising free metal ions in aqueous solution and corresponding to the one or more metals in the original sample; and withdrawing the pretreated aqueous sample comprising the free metal ions in aqueous solution. The pretreated aqueous sample can be analyzed for metal content using any desired conventional analysis technique.

Fluidic systems and reagent carriers suitable for storing reagents in a desirable manner are generally provided. In some embodiments, a reagent carrier stores a liquid film comprising a solid reagent and/or stores different reagents in different locations. In some embodiments, a fluidic system comprises a reagent carrier constrained such that it comprises an elongated axis positioned within 30° of a vertical axis of the fluidic reservoir.

The present invention provides a detection device comprises a testing element and a transparent area, wherein the testing element comprises a detection area which is configured to detect a presence of an analyte in a liquid sample; the transparent area is configured to read the test result on the detection area through the transparent area; a part of the transparent area contacts a part of the detection area, or the detection area and the transparent area are arranged in one sealed space, thus to make the air in the sealed space not exchange with the air outside the sealed space; the scheme can reduce the mist to ensure the test result is displayed clearly.

A biological sample collection system includes: a sample collection vessel having a sample collection chamber for receiving a biological sample; a sealing cap including a reagent chamber for storing a sample preservation reagent and being configured to associate with the sample collection vessel; and a selectively movable valve at least partially disposed within the sealing cap. The selectively movable valve includes a post with an interior chamber and fluid vent and a valve head associated with a distal portion of the post that initially occludes the fluid vent when the valve is in the closed configuration. Associating the sealing cap with the sample collection vessel causes a physical rearrangement of the post and the valve head in order for the fluid vent to become unoccluded by the valve head, thereby placing the valve in an open configuration and allowing fluid communication between the reagent chamber and the sample collection vessel.

The present invention relates to a liquid handling and processing tool for analyzing a biological sample. Furthermore, the present invention relates to a fluid processing and detection module for processing a liquid sample and for detecting analyte in the sample.