A drum coater for applying a surface layer on bulk-like materials includes a rotatably mounted drum for accommodating bulk-like materials, inlet and outlet openings, at least one spray nozzle for applying the surface material, a drying device for a drum interior, at least first and second radially-offset mixing tools in the drum, the first mixing tool protruding into the drum interior. The at least one second mixing tool has at least one mixing surface such that the first mixing tool is at least partially arranged on the drum inner surface and the at least one second mixing tool has at least one opening on the at least one mixing surface. A mixing tool to be used in a drum coater to gently blend and/or homogenize bulk-like materials has a first mixing surface angled relative to a second mixing surface, at least one mixing surface having at least one opening.

A method of producing a tablet in which an uncoated tablet is coated by a coating agent, the method including: a coating process of coating uncoated tablets with a coating agent by spray coating the coating agent onto tablets that are churned and tumbled inside a container, and drying the tablets inside the container by supplying drying air into the container and exhausting air from the container, wherein spray coating conditions, including air supply temperature, air supply rate, and spray speed, are controlled according to the weight of the coating agent with which the uncoated tablets are coated, such that the humidity of air exhausted during spray coating is within a range of from 14% RH to 30% RH.

The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

A frame for holding a small object while coating the small object with a coating composition includes a first plate and a second plate coupled to the first plate and movable relative to the first plate. The first plate includes a platform having a longitudinal axis. The second plate includes a wall adjacent a hole, wherein the hole receives the first plate's platform and is configured to allow the wall to move relative to the platform in a direction along the platform's longitudinal axis. When the first and second plate are coupled together, the first plate's platform and the second plate's wall define a receptacle of the frame that is operable to hold a small object.

The present invention relates to a tablet composition comprising a granulate consisting of a co-precipitate on a substrate, wherein the co-precipitate comprises enzalutamide in amorphous form and a cellulosic concentration enhancing polymer. The invention further relates to the use of said composition as a medicament, particularly in the treatment of castration-resistant prostate cancer.

Described herein are solid pharmaceutical compositions of brown algae extracts and methods for making solid pharmaceutical compositions of brown algae extracts. In some embodiments, the brown algae extract is derived from Ecklonia cava.

The purpose of present invention to provide a method for the production of an easy-to-take solid preparation, which is mainly characterized in that a coating processing for the easy-to-take property is simply performed by using a gelling agent in a dry process, without going through a wet condition, the easy-to-take solid preparation and the like.

The present invention relates to a dry-process method for the production of an easy-to-take solid preparation wherein a compression-molded core is coated with a coating agent comprising a gelling agent that will show slipperiness when it is brought into contact with water, comprising directly applying only powder of the coating agent to a mortar inner surface, the bottom end surface of an upper-pestle, and the top end surface of a lower-pestle, and subsequently loading and integrally compression-molding a core-molding material; a powder composition for coating the solid preparation, which comprises a water-soluble polymer to be used in the aforementioned production method, and the like.

The present invention relates to oral dosage forms of diclofenac, and processes for their manufacture, that provide a rapidly absorbed dose of diclofenac without requiring milling of diclofenac to submicron sizes.

The present invention relates to a process of manufacture of dosage forms for oral administration of meloxicam, or a salt thereof.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.