An exemplary method of printing medications on digestible substrates is described. Single component nonmagnetic toners with active pharmaceutical ingredients (API) embedded or dissolved in the toner are used. The binders for the toner are digestible. The printing process includes loading the single component non-magnetic toners from a sump to a donor roll and developing them either directly onto the substrate or through the use of an intermediate member. Traditional xerographic charge and exposure can be used to make the tablet imprints. Dosage is controlled through solid area or halftone development (when charge and exposure are used). The printed first layer may undergo cold or warm pressure fusing. This medicament layer is then subjected to another station to print a second layer of medical tablet. Multiple stations may be used to build up a complete personalized tablet. Optionally, a final station prints protective overcoat materials to finalize the tablet.

In the coating apparatus for granular bodies is disposed a rotatable hollow cylindrical drum in which there is an introduction apparatus for granular bodies and at least one movable separating element therein, with which a cycle zone can be partly separated from a downstream cycle zone and a movement of the at least one separating element that leads to release is achievable. An interior of the drum is divided into at least one cycle zone and a further cycle zone. A spray apparatus is disposed in one cycle zone, and an outlet in a cycle zone arranged downstream. A separating element is movable from a closed position into an open position. A separating element has a clear space above the closed subregion and an opening between one cycle zone and a cycle zone arranged thereafter, through which granular bodies can pass.

The present invention proposes an implant coating and drying device, including a chip sorter, a slide maker, a coating pool, a tablet pipe, a tablet conveying device, and a drying device. The chip sorter is connected to the slide maker, the shape of the coating pool is a circular arc. The coating pool is filled with coating solution. The inlet of the tablet pipe is connected with the slide maker, and the outlet of the tablet pipe is connected with the drying device, the tablet conveying device is used to deliver the implant tablet within the tablet pipe. The present invention proposes an implant coating and drying device, which has the advantages of simple structure and convenient operation, and avoids the defect of the prior art that the implant tablets adhere to each other, the coating is damaged, and the release degree of the implant tablet cannot be stabilized. The present invention proposes the implant coating and drying device is suitable for mass production.

The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.

A solid dosage product having a tailored dissolution profile comprises a carrier block defining a plurality of compartments where each respective compartment is configured to receive one or more active pharmaceutical ingredient and the carrier block being digestible within an animal such that each respective active pharmaceutical ingredient is controllably released; and one or more coating layers applied to the carrier block. A method for manufacturing a solid dosage product having a tailored dissolution comprises manufacturing a digestible carrier block where the carrier block defines a plurality of compartments with each respective compartment configured to receive an active pharmaceutical ingredient; filling a respective compartment with a respective active pharmaceutical ingredient; and coating the carrier block with one or more coating layers.

A coating apparatus includes an open/close valve having a motor that allows control of opening operation and closing operation in accordance with electric signals applied from a controller. The coating apparatus further includes a suck back valve having a motor that allows control of a volume variation in a flow path for suck back that is in communication with an upstream side and a downstream side of a pipe in accordance with electric signals from the controller. The controller allows control of start of the closing operation of the open/close valve and start of suction operation of the suck back valve through application of the electric signals to the respective motors. This achieves simple adjustment of liquid cut-off.

Described is a nozzle for spraying substances, in particular dispersions, emulsions or suspensions.

An apparatus for coating pharmaceutical particles such as drug dosage forms or pellets is provided which includes a drum assembly mounted for rotation about a cylindrical axis of the drum and which includes an outer drum section and an inner perforated drum section mounted concentrically on an interior of the outer drum section such that an annular chamber is formed between the perforated inner drum section and the outer drum section. Two or more baffle plates are attached between an outer surface of the inner perforated drum and an inner surface of the outer drum which are configured to act as baffles to restrain or regulate the flow of air which define two or more compartments depending on the number of baffle plates. One end of the drum assembly includes an end plate with a central aperture for use in loading pellets into the drum and provide access to coating constituents that are pumped into the drum interior during the coating process. An air distribution plate is attached at the other end of the drum and has air flow passageways and is interfaced with an air introduction plate having air inlet and outlet passageways. As the drum rotates the air flow passageways in the distribution plate alternately come into flow communication with the air inlet and outlet passageways in the air introduction plate thereby providing a flow path of air into the perforate inner drum and out of the drum assembly.

A coating apparatus (1) and method are disclosed for coating tablets in a rotating drilled container (2) at the outlet of which a rotating annular element (11) operates that is coaxial with the container, in which in an initial transition phase the annular element rotates in a direction that is opposite the rotation direction of the container to retain the tablets inside the container, forming a bed of tablets until a desired level is reached, and in a stationary phase the annular element rotates in a direction that is the same as the rotation of the container to permit the exit of the tablets, until the quantity of tablets entering the container is the same that the quantity exiting.

The present invention proposes an implant coating and drying device, including a chip sorter, a slide maker, a coating pool, a tablet pipe, a tablet conveying device, and a drying device. The chip sorter is connected to the slide maker, the shape of the coating pool is a circular arc. The coating pool is filled with coating solution. The inlet of the tablet pipe is connected with the slide maker, and the outlet of the tablet pipe is connected with the drying device, the tablet conveying device is used to deliver the implant tablet within the tablet pipe. The present invention proposes an implant coating and drying device, which has the advantages of simple structure and convenient operation, and avoids the defect of the prior art that the implant tablets adhere to each other, the coating is damaged, and the release degree of the implant tablet cannot be stabilized. The present invention proposes the implant coating and drying device is suitable for mass production.