A coating apparatus and method are disclosed for coating tablets with a film, in which the tables transit through a drilled first container where they are coated, then exit the first container and are removed from a rotating element provided on the periphery of a plurality of removal members that are spaced angularly apart from one another, in which each removal member removes a quantity of tablets, raises the removed tables as far as a certain height and then discharges the tablets into a chute that conveys the tablets into a second rotating drilled container, with delicate transfer of the coated tablets from one container to the next.

Method for coating bulk material comprises: starting a coating apparatus (1; 101) according to a start procedure on a discrete load of bulk material to be coated; operating the coating apparatus (1; 101) in stationary mode, by introducing a continuous flow of uncoated bulk material into the coating apparatus (1; 101) and obtaining at the outlet of said coating apparatus (1; 101) a continuous flow of coated bulk material having a predetermined stationary coating weight gain (W %); in which the coating apparatus (1; 101) comprises a first rotatable tubular container (2; 102) provided with a first dispensing device (5; 105) for dispensing coating material on the bulk material (M) in a plurality of internal successive adjacent spray zones between a first inlet and a first outlet of the first container (2; 102); a second rotatable tubular container (6; 106) arranged to receive bulk material (M) coming from the first container (2), the second rotatable tubular container (6; 106) being provided with a second dispensing device (9; 109) for dispensing coating material on the bulk material (M) in a plurality of internal successive adjacent spray zones between a first inlet and a second outlet of the second container (6, 106); conveying means arranged to convey the bulk material (M) from the first container (2; 102) to said the second container (6, 106); and in which the start procedure comprises in succession: dispensing coating material onto the load, maintaining the coating material inside the first container (2; 102) until coated bulk material is obtained with said predetermined stationary coating weight gain (W %); a transition phase to the stationary mode in which a flow of the load of coated bulk material is transferred from the first container (2; 102) to the second container (6; 106) and is supplied with an equal flow rate of bulk material to be coated to the first container (2; 102); dispensing coating material on the same flow rate of bulk material to be coated entering the first container (2; 102) activating in sequence the spray zones inside first container (2; 102) to obtain at the first outlet a coated bulk material with an established weight gain (U %); dispensing coating material on the same flow rate of bulk material to be coated having the established weight gain (U %) entering the second container (6; 106), activating in sequence the spray zones inside the second container (6; 106) to obtain a coated bulk material with the predetermined stationary coating weight gain (W %).

The invention relates to a method for producing pharmaceutical tablets, in which method pressed tablet articles are formed and given a coating, wherein the pressed tablet articles are, before they are given a coating, stored in an intermediate storage area (10) for a product-specific hardening period and are then automatically removed from the intermediate storage area (10) for further processing, wherein a system control unit (17), in which the product-specific hardening periods can be or are stored, detects the time at which the pressed tablet articles are placed into the intermediate storage area (10) and once the product-specific hardening period has come to an end, initiates the automatic removal of the pressed tablet articles. The invention further relates to a system for producing pharmaceutical tablets, having at least one tablet press (2) and at least one coater (14), which is arranged downstream of the tablet press (2) and which gives the pressed tablet articles formed in the tablet press (2) a coating, wherein the system has containers (8), which are configured to receive the pressed tablet articles ejected from the tablet press (2), the system comprises an intermediate storage area (10) having at least two storage spaces (11), the system has a handling system (9) that brings the containers (8) to the intermediate storage area (10) and removes them therefrom, and the system comprises a system control unit that controls the handling system (9), wherein in the system control unit (17), product-specific hardening periods can be or are stored and the system control unit (17) detects the content of a container (8), the storage space (11) assigned to a container (8) in the intermediate storage area (10), and the start of the hardening period and, once the hardening period has come to an end, actuates the handling system (9) to remove the corresponding container (8) from the intermediate storage area (10) and to transport it for further processing.

A tamperproof dosage form for oral administration comprising: a caplet comprising first and second ends, a middle region extending between said first and second ends, parallel and oppositely disposed top and bottom faces, and a land interposed between the top and bottom faces and extending along a perimeter of the caplet on a plane parallel to a caplet length axis; and first and second shells, each comprising an open end and a closed dome-shaped end, each fitted over at least a portion of the caplet, the portion comprising at least the first and/or second ends of the caplet and at least part of the middle region. An adhesive substance being arranged between the caplet and the shells at least over a portion of the top and/or bottom faces proximal to the first and second ends of the caplet and a corresponding portion of an inner surface of the closed dome-shaped end of the shells to fixedly join the shells to the caplet.

The present invention relates to a method of manufacturing an orally disintegrating dosage form which masks a bitter or unpleasant taste. A composition including a ratio of excipients and a coated active substance prevents a coating layer on the active substance from being destroyed during manufacture.

In an apparatus and method of manufacturing a multi-column multi-medicine oral dissolving film according to the present invention, all processes from film feeding, medicine coating, and medicine drying to product packaging are implemented as continuous automation processes, and under the automation processes, different kinds of medicines are coated on a base film in multiple columns in a signal layer by using a plurality of nozzles supplied with the different kinds of medicines, so that it is possible to improve productivity through the automation processes, to ensure product quality due to efficiency during drying caused by maintaining the thickness of the product, and to provide a convenience in the case of taking various kinds of small-amount medicines at one time or in the case of separately and selectively taking different kinds of medicines.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

A continuous skin packaging and coating apparatus and a coating method for tablets. The continuous skin packaging and coating apparatus comprises a lower coating film unreeling roller, a waste edge reeling roller, an upper coating film unreeling roller, a lower coating film heating component, an upper coating film heating component, a first mold provided with a first tablet placing hole, a second mold provided with a second tablet placing hole, a heat-sealing plate, a cutting component, a blank tablet implanting component, and an operating mesa. The lower coating film unreeling roller and the waste edge reeling roller are provided on either side of the operating mesa. The lower coating film heating component, the blank tablet implanting component, the upper coating film unreeling roller, the upper coating film heating component, the heat-sealing plate, and the cutting component are sequentially provided above the operating mesa. The first mold is provided under the operating mesa below the blank tablet implanting component. The second mold is provided under the operating mesa below the heat-sealing plate. The upper coating film heating component is provided below the upper coating film unreeling roller.

The disclosure encompasses systems and methods for performing high temperature and high humidity curing of tablets using air flow delivered from a recirculating air handler to a pan coater of a tablet coating device. The recirculating air handler may be integrated into a preexisting tablet coating device so that the air flow may be delivered by the preexisting air handler or by the recirculating air handler as desired.