To provide a gnetin C high content melinjo extract rich in the content of gnetin C which is useful for prevention and/or treatment of diseases such as metabolic syndrome, diabetes mellitus, hypertension, gout, cancer, collagen disease, periodontal disease and the like and further for beauty care and/or protection of skin and of which intake/dosage or use amount can be reduced. An extract is extracted from melinjo fruit, by using an extraction solvent which is a mixed solvent obtained by blending at least one of an emulsifier, a cycrodextrin and an acid into water and/or an organic solvent.

Disclosed is a genome stability enhancer comprising, as an active ingredient, at least one member selected from the group consisting of enzymatically degraded royal jelly, gnetum or its extract, and gnetin C.

Disclosed is a genome stability enhancer comprising, as an active ingredient, at least one member selected from the group consisting of enzymatically degraded royal jelly, gnetum or its extract, and gnetin C.

It is an object of the present invention to provide a composition for improving intestinal flora. The composition for improving intestinal flora includes gnetin C and/or a glycoside thereof for proliferating Akkermansia having an effect of improving the intestinal flora.

It is an object of the present invention to provide a composition for improving intestinal flora. The composition for improving intestinal flora includes gnetin C and/or a glycoside thereof for proliferating Akkermansia having an effect of improving the intestinal flora.

The present invention relates to a method for treating a coronavirus infectious disease and a complication thereof, including: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture including Ephedra sinica, Armeniacae Semen amarum, Glycyrrhizae radix et rhizoma, Gypsum fibrosum, Descurainiea semen, stephaniae Tetrandrae radix, Scutellariae radix, Poria, rhizoma alismatis, Polyporus umbellatus, Atractylodis rhizoma, Asteris radix et rhizoma, Tussilago farfara, Pinelliae rhizoma, and Rhei radix et rhizoma.

The present invention relates to a method for treating a coronavirus infectious disease and a complication thereof, including: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture including Ephedra sinica, Armeniacae Semen amarum, Glycyrrhizae radix et rhizoma, Gypsum fibrosum, Descurainiea semen, stephaniae Tetrandrae radix, Scutellariae radix, Poria, rhizoma alismatis, Polyporus umbellatus, Atractylodis rhizoma, Asteris radix et rhizoma, Tussilago farfara, Pinelliae rhizoma, and Rhei radix et rhizoma.

A method for treating pleural effusion includes: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture comprising Poria, Polyporus, Rhizoma Alismatis, Atractylodis Rhizoma, Pimenta Officinalis, Zingiberis Rhizoma, Aconiti Lateralis Radix Praeparata, Phellodendron Amurense, Angelica Sinensis, Astragalus Membranaceus, Stephaniae Tetrandrae Radix, Descurainiea Semen, Ephedra Sinica, Armeniacae Semen Amarum, Ginseng Radix et Rhizoma, Anredera Cordifolia and Velvet Antler.

A method for treating pleural effusion includes: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture comprising Poria, Polyporus, Rhizoma Alismatis, Atractylodis Rhizoma, Pimenta Officinalis, Zingiberis Rhizoma, Aconiti Lateralis Radix Praeparata, Phellodendron Amurense, Angelica Sinensis, Astragalus Membranaceus, Stephaniae Tetrandrae Radix, Descurainiea Semen, Ephedra Sinica, Armeniacae Semen Amarum, Ginseng Radix et Rhizoma, Anredera Cordifolia and Velvet Antler.

Provided herein are tumor-antigen VCX/Y specific peptides and engineered VCX/Y specific T cell receptors. Also provided herein are methods of generating VCX/Y-specific immune cells and their use for the treatment of cancer. In addition, the VCX/Y-specific peptides may be used as a vaccine.