A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent is in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.

The present invention relates to compositions comprising microparticles and methods of using the same. Provided are compositions comprising a nanostructured material with tortuous pores. Also provided are compositions comprising a nanostructured material comprising metal. Pharmaceutical compositions comprising the compositions disclosed herein are also disclosed. The compositions and pharmaceutical compositions disclosed herein enhance wound healing properties of solutions, dispersions, creams, gels, or dressings applied to wounds. Also provided are methods of using the disclosed compositions and pharmaceutical compositions.

There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 g/cm.sup.2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopedic implants, orthopedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.

The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention relates to a method for adhering a first tissue surface to a second tissue surface in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on at least one of the tissue surfaces, and approximating the surfaces for a time sufficient for allowing the surfaces to adhere to each other. The present invention also relates to a method for adhering a material to a biological tissue in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on the surface of the material and/or the biological tissue and approximating the material and the biological tissue for a time sufficient for allowing the material and the biological tissue to adhere to each other.

There is provided a composition comprising covalently linked segments of for example, polycaprolactone and polyethylene glycol that are linked by a cross-linker. Such a composition foams in the presence of a catalyst and a solution containing an oxygen forming chemical like hydrogen peroxide. The foamed composition retains oxygen for delivery to, for example, a wound, where it aids in healing.

Compositions comprising a biguanide derivative like chlorhexidine are disclosed for use in methods of preventing bacterial growth in a wound or surgical site of a subject. The methods involve irrigating or coating the wound or surgical site with the solution and then closing or covering the wound or surgical site without washing the solution from the wound or surgical site with saline or water. Articles such a breast implants, tissue expander, titanium implants, tubes, surgical drains, and devices designed to ease the insertion or for sterile insertion of implants (e.g. funnels) that are coated with a biguanide derivative are also disclosed.

The present invention includes the composition and manufacturing of a product to treat various types of infections, and diseases ailments. The invention embodies a disposable absorbent or nonabsorbent article comprising an unbound/freely associating adsorbent porous carbonaceous material for the entrapment and/or treatment of pathogens and adverse biological by-products. The product form includes three dimensional carriers such as tampons, panty liners, incontinence pads, diapers, sanitary towels, swabs, cotton balls, pouches, and/or plugs, which contain adsorbent porous carbonaceous material that effectively reduces and/or eliminates adverse situations sourcing from pathogens and harmful biological by-products, including fungi, bacteria, viruses, and parasites. The article is used to treat yeast infections, vaginitis, sexually transmitted diseases, tooth infections, abscess, nail-bed and cuticle infections, and other ailments by way of internal insertion and/or completely covering of the body cavity, mucous membrane, and/or affected areas, creating a clear and direct path for contact with pathogens and adverse biological by-products.

The present invention includes the composition and manufacturing of a product to treat various types of infections, and disease ailments. The invention embodies a disposable absorbent or nonabsorbent article comprising an unbound/freely associating adsorbent porous carbonaceous material for the entrapment and/or treatment of pathogens and adverse biological by-products. The product form includes three dimensional carriers such as tampons, panty liners, incontinence pads, diapers, sanitary towels, swabs, cotton balls, pouches, and/or plugs, which contain adsorbent porous carbonaceous material that effectively reduces and/or eliminates adverse situations sourcing from pathogens and harmful biological by-products, including fungi, bacteria, viruses, and parasites. The article is used to treat yeast infections, vaginitis, sexually transmitted diseases, tooth infections, abscess, nail-bed and cuticle infections, and other ailments by way of internal insertion and/or completely covering of the body cavity, mucous membrane, and/or affected areas, creating a clear and direct path for contact with pathogens and adverse biological by-products.

Thus, the present invention provides a composition in powder form comprising highly dispersed silica particles, polymethylsiloxane particles, and at one or both of a cationic surfactant and an antimicrobial substance, wherein at least 25% by weight of the cationic surfactant is present in primary polymethylsiloxane particles carrying the cationic surfactant on their surface and/or in agglomerates of these primary particles, and/or at least 25% by weight, of the antimicrobial substance is present in primary highly dispersed silica particles carrying the antimicrobial substance on their surface and/or in agglomerates of these primary particles.

The present invention relates to improved hemostatic compositions comprising cellulose-based fibers supplemented with compounds, preparation and use thereof.