A wound dressing includes a dressing member or body which has a wound-facing side intended to be placed adjacent a wound, such a surgical wound. The wound-facing side of the wound dressing is provided with a plurality of microstructures in the form of denticles. Each of the denticles includes a body that extends from a base of the denticle laterally over, but not connected to, the dressing member. The denticles are arranged in an overlapping manner such that the body of one denticle overlaps the body of one or two other adjacent denticles. The denticles create a microstructured surface that resists bioadhesion, and which, upon flex of the wound dressing, create mechanical interference with each other that can dislodge organisms that manage to adhere to the wound-facing side of the wound dressing in spite of the microstructured surface.

An artificial flower, plant, or other botanical is produced from an aqueous agar-based solidifying mixture. The artificial botanical may be colored as desired by adding one or more colorants. The artificial botanical may also be scented by adding a perfume, odorant, or other scent. Because the artificial botanical is produced using the aqueous agar-based solidifying mixture, no animal-based gelatin products are. The artificial botanical may thus also be edible and satisfies vegan diets. The artificial botanical may thus also be flavored by adding a flavoring, such as fruit, concentrate, or sweetener. The artificial botanical may be all-natural and edible by adding mica powder as the colorant and by adding glycerin as the flavoring.

A functional polymeric cutting edge structure and methods for manufacturing cutting edge structures using polymeric materials are provided. A razor blade for use in a razor cartridge or a blade box for assembly in a razor cartridge frame may be formed using the present invention.

A nucleic acid film fabrication method, includes: a mixing step in which a nucleic acid is added in powder form to distilled water or deionized water to prepare a mixed solution; a stirring step in which the mixed solution is stirred; a mixed solution application step in which the mixed solution is applied to a mold corresponding in shape to a final product of a nucleic acid film; and a drying step in which the mixed solution applied to the mold is dried to be formed into the nucleic acid film, wherein the mold has a groove formed thereon in a thickness direction thereof, such that the nucleic acid film passing through the drying step has a protrusion protruding from one surface thereof toward human skin to correspond to the groove.

A method employs a first polymeric material to deposit first and second pattern layers laterally shifted from each other such that laterally shifted pattern layers form between them an empty volume with a variable cross-section that varies along with the first and second pattern layers. A second polymeric material is cast in the empty volume between the first and second pattern layers to cast a complex-shaped 3D object identical in shape to the empty volume between the first and second pattern layers. Radiation is applied to cure the first and second polymeric materials. The first polymeric material is a water breakable material composition including acrylamide, methacrylamide, acrylate, acrylic acids, and acrylic acid salts, hydroxy(meth)acrylate, carboxy(meth)acrylate, acrylonitrile, carbohydrate monomers, methacrylate and polyfunctional acrylics.

The present invention relates to a microneedle comprising a plurality of portions, wherein the plurality of portions comprise a distal end portion and a proximal end portion, at least two of the plurality of portions are made of different polymers, and the distal end portion is made of at least one polymer with high swellability and high viscoelasticity.

The present invention provides a method for the preparation of an asymmetric membranes. More particularly, the new method relates to the use of a crosslinker contacted via vapour or liquid phase with the surface layer of a cast polymer film, followed by the immersion of said film in a coagulation bath. The formation of a crosslinked skin layer and the solidification of the membrane bulk can thus be decoupled in time.

A transdermal drug delivery patch includes a flexible base layer, and a plurality of microneedles disposed at one surface of the base layer and including a biodegradable polymer and a drug. Each of a plurality of microneedles is formed as a star-shaped pyramid including a plurality of protrusions extending in a radial direction, and a concave shape is formed between two protrusions adjacent along a circumferential direction among a plurality of protrusions.

A template (100) for controlling application of material (620) around a protuberance (610) is disclosed. The protuberance (610) extends from a workpiece (600) and has a base (612). The template (100) comprises a first portion (110) and a second portion (130), removably attached to the first portion (110). The first portion (110) comprises a first inner peripheral edge (111) that at least partially defines a positioning opening (115) and that is geometrically complementary to at least a portion of the base (612) of the protuberance (610). The first portion (110) also comprises a first-portion environment-facing surface (114). The second portion (130) comprises a second-portion environment-facing surface (136), which partially overlaps with and is removably attached to the first-portion workpiece-facing surface (114), forming an interface (120) between the first-portion workpiece-facing surface (114) and the second-portion environment-facing surface (136).

A transdermal drug delivery patch according to an exemplary embodiment of the present invention includes: a flexible base layer; and a plurality of microneedle disposed at one surface of the base layer. Each of the plurality of microneedles includes a biodegradable polymer and a drug and has an empty space inside. Each of the plurality of microneedles is formed as a star-shaped pyramid including a plurality of protrusions extending in a radial direction, and a part between two protrusions adjacent along the circumferential direction among the plurality of protrusions is concave.