Provided is a method for manufacturing a transdermal absorption sheet which suppresses the cost of manufacturing equipment and prevents deterioration of a pharmaceutical preparation or a raw material thereof, and an intermediate. A mold filled with a first polymer solution is stored in a drying container in an aseptic environment, and the first polymer solution in the mold stored in the drying container is dried outside an aseptic environment. In a case where a surface of the drying container in which the mold is stored is irradiated with an electron beam from an electron beam source, a shield that shields an electron beam is arranged at a position on a straight line connecting the electron beam source and the needle-like recessed portions.

The present disclosure includes dental appliances and methods of making and using such appliances. One method for forming a dental appliance includes forming a liquid thermoset polymer material into a semi-solid first shape, thermoforming the semi-solid first shape of thermoset polymer material onto a dentition mold, and curing the thermoset polymer on the dentition mold with a curative trigger to complete a molecular cross-linking reaction.

A nucleic acid film fabrication method, includes: a mixing step in which a nucleic acid is added in powder form to distilled water or deionized water to prepare a mixed solution; a stirring step in which the mixed solution is stirred; a mixed solution application step in which the mixed solution is applied to a mold corresponding in shape to a final product of a nucleic acid film; and a drying step in which the mixed solution applied to the mold is dried to be formed into the nucleic acid film, wherein the mold has a groove formed thereon in a thickness direction thereof, such that the nucleic acid film passing through the drying step has a protrusion protruding from one surface thereof toward human skin to correspond to the groove.

The present disclosure relates to an apparatus and a process which can continuously produce microneedles using a conveyor system and decomposition or vacuum. By using the microneedle production method and apparatus according to the present disclosure, continuous mass production of microneedles is available, and therefore it is possible to reduce the input of manpower and produce a large amount of products compared to the conventional production method.

The present invention relates to a method for preparing a plurality of imprints on an inner surface of a polymeric substrate comprising the steps of: a) contacting a liquid polymeric mixture with a mold having an imprint forming surface thereon; b) curing the liquid polymeric mixture of step a) to form said polymeric substrate having said plurality imprints on said inner surface, when cured; and c) removing said mold from said polymeric substrate. There is also provided a method of forming the mold having the imprint forming surface thereon.

Embodiments of the invention are directed to a molding system and kit for molding a modeling compound. The molding system is generally comprised of an openable interlocking molding device, the openable interlocking molding device is configured to cast external features onto a modeling compound surface by securing the modeling compound within a molding cavity of the openable interlocking molding device. Further, the molding system includes a substrate with movable joints that is configured to be enveloped by the modeling compound prior to casting the external features onto the modeling compound by the interlocking molding device.

The present innovation is an innovative process for the manufacturing of jewelry or jewels with silver or gold adornments, such as bracelets, necklaces, earrings, pendants, among other artifacts, from the re-utilization of strings of tennis rackets disposed of by players, forming a polymer mass that is treated to generate the pieces, such as beads, which make up the final artifact.

Provided is a method for manufacturing a transdermal absorption sheet which makes it possible to manufacture a transdermal absorption sheet with a stable shape. The method for manufacturing a transdermal absorption sheet includes a step of forming a drug layer (110) on needle-like recess portions (42) of a mold (50) having the needle-like recess portions (42), a step of supplying a polymer layer forming solution (112) to the inside of a step portion (52) of the mold (50), a step of drying the polymer layer forming solution (112) so as to form a polymer layer (114) and a transdermal absorption sheet (120), and a step of peeling off the transdermal absorption sheet (120) from the mold (50). In the step of peeling off, pressing force is applied to a part of the step portion (52) in a second direction (B) opposite to a first direction (A) in which the transdermal absorption sheet (120) is released from the mold (50), and the transdermal absorption sheet (120) is aspirated with a vacuum suction pad (160) from a side opposite to the mold (50) so that the transdermal absorption sheet (120) is peeled off from the mold (50) in the first direction (A).

Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle.

A method of applying material to a workpiece around a protuberance, extending from the workpiece, comprises advancing a template toward the workpiece to insert the protuberance into a positioning opening, located in a first portion of the template. The method also comprises removably attaching at least a second portion to the workpiece and separating the first portion of the template from the second portion along an interface while at least the second portion remains attached to the workpiece. The method further comprises applying the material to the workpiece around the protuberance such that the material overlaps a second inner peripheral edge of the second portion of the template, but does not overlap a visual material-placement indicator. The method also comprises detaching the second portion of the template from the workpiece.