Liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a container for storing the liquid drug, an end cap having an ejection opening, a filter element, and a piston that is repositionable relative to the container to selectively eject a volume of liquid drug from the ejection opening. The filter element filters the liquid drug prior to ejection from the ejection opening. The liquid drug cartridge can be coupled with an inhaler that includes an aerosol generator. The aerosol generator includes a vibratable membrane onto which the liquid drug is ejected. The liquid drug is aerosolized by the vibration of the membrane for inhalation by a user.

An actuator for a pressurized metered dose inhaler providing a significant reduction in the non-respirable coarse fraction of the emitted aerosol medicament impacting in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient, due to the fact that the mouthpiece portion has a central rounded opening of a well-defined width and distance from the nozzle aperture and also provided with a cylindrical recess, whose central axis is aligned with the central longitudinal axis of the mouthpiece portion and with the central longitudinal axis of the nozzle channel.

There is provided an aerosol generating device, comprising an inhalation outlet; a chamber for holding a material, the material capable of generating a vapour when heated; a heater for heating material held in the chamber; an air inlet connected by an air inlet passage to the chamber; a vapour-cooling module providing a fluidic connection between the chamber and inhalation outlet, the module configured to cool a vapour passing there through. In use, suction at the inhalation outlet causes air to enter the chamber via the air inlet, thereby transporting the vapour generated in the chamber through the vapour-cooling module to the inhalation outlet, such that the temperature of the vapour exiting the device through the inhalation outlet is substantially lower than the temperature of the vapour generated in the chamber. The aerosol generating device thereby provides a means whereby a vapour generated in the chamber is substantially cooled during transport from the chamber through the mouthpiece to the user.

The present invention provides an end fitting (1) for a spacer assembly and a spacer assembly having such an end fitting for fitting to a drug delivery inhaler device (21). The spacer assembly has a spacer body (17) with opposing first and second axial ends. The end fitting comprises an end panel having an upper end face (2) and a lower end face (3). A lower annular recess (4) is provided on the lower end face for receiving the first axial end (18) of the spacer body in a first configuration. An upper annular recess (12) is provided on the upper end face for receiving the second axial end (20) of the spacer body in a second configuration. The end fitting further comprises an open-ended tubular projection (16) extending from the upper end face and an aperture extending through the end panel from the lower end face to the tubular projection.

An inhalation device for inhaling a vaporized substance that includes metering capabilities to inform a user when a particular amount of substance has been consumed. The inhalation device can include a sensor that senses the vaporized substance and a processor that utilizes data from the sensor to meter the amount consumed. The inhalation device can also define a session, which is a time in which a user can consume a particular amount. During the session, a user can start and stop inhaling and resume inhaling. When the user stops inhaling the inhalation device will halt vapor production and will resume production when the user resumes inhaling.

Provided is a Dry Powder Inhaler (DPI) arrangement comprising a DPI arranged in fluid communication with a spacer device (110) comprising a bag (112) and a body (118) including inlet (114) and opposed outlet (116), the inlet (114) and opposed outlet (116) being provided on, and integral with, the body (118). The body (118) and bag (112) combine to form chamber (120) for operatively receiving vaporised dry powder medication. The inlet (114) and outlet (116) each are in the form of a port that is in fluid flow communication with the chamber (120). The inlet (114) and outlet (116) define, and are separated by, a broad V-formation formed as part of the body (118). The body (118) further includes an elliptical lower perimeter (118.1) defining flange (118.2), for demountably receiving bag (112).

A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

A cartridge for use in an aerosol delivery device, the cartridge including: an outer housing configured to contain at least an aerosolizable composition, the outer housing including an exit portal at a proximal end thereof for passage of an aerosol; and a bottom cap positioned at a distal end of the outer housing that is configured for insertion into a receiving chamber of a control device of the aerosol delivery device. The outer housing defines a front face portion and a rear face portion interconnected with sidewalls, wherein the front face portion has an asymmetrical configuration relative to the rear face portion, such asymmetrical configuration being effective such that the cartridge engages the control device of the aerosol delivery device in only a single orientation. A control device is also provided herein.

A device for monitoring adherence of a patient to a prescribed regimen is provided. The device has a pulmonary delivery device fluid, an adapter in communication with the delivery device and a dispenser in fluid communication with the adapter. A pressurized drug, contained in the pulmonary delivery device, can be delivered from the pulmonary delivery device to the patient through the adapter and the dispenser. A sensor is mounted to the adapter or the dispenser for detecting a temperature or pressure change caused by the movement of the drug from the pulmonary delivery device to the patient and generating a feedback signal based on the change. The feedback signal is further processed for generating a signal indicating a successful deliver of the drug to the patient.

In one embodiment, a device in a network detects an anomaly in the network by analyzing a set of sample data regarding one or more conditions of the network using a behavioral analytics model. The device receives feedback regarding the detected anomaly. The device determines that the anomaly was a true positive based on the received feedback. The device excludes the set of sample data from a training set for the behavioral analytics model, in response to determining that the anomaly was a true positive.