A system for the therapeutic treatment of joints comprising a composite material comprising a biodegradable polymer matrix and a plurality of piezoelectric particles adapted to generate local electric charges in response to an external stimulation made by means of ultrasound, said plurality of piezoelectric particles being dispersed in the matrix. The composite material also comprises a plurality of stamina cells dispersed in the biodegradable polymer matrix and a plurality of carbon-based particles. The system also comprises a releasing device, arranged to deposit the composite material in a joint cavity at predetermined areas of the cartilage, and a stimulator device arranged to emit ultrasound at a predetermined frequency, a predetermined intensity and for a predetermined time of application, in such a way that, when the device is located near a joint wherein the composite material has been deposited, said ultrasound stimulate the plurality of piezoelectric particles.

The present invention discloses an advance in enhanced stability, enhanced solubility, and enhanced uniqueness towards a micro needling stamper device by proposing an improved process by presenting a technique where skin care products are delivered by way of a needling device is presented. The device has a suction that operates in the casing of the needles. When the stamping of the microneedles occurs, this suction feature lift the skin from it's a regular lying surface. The suction feature promotes blood circulation which will promote cell repair and aide in regeneration. This vacuum like suction separates different layers of tissues, thus microtrauma from the needles is more confined to the layer desired; the epidermis. This also triggers an inflammatory response flooding the area with white blood cells, platelets, and other healing aids for the re-generation process.

The present disclosure generally relates to methods, devices and systems relating to applying drugs or therapeutic agents to biological conduits, e.g., vascular lumens. More specifically, the present invention comprises enhancing the uptake of drugs or therapeutic agents encapsulated in microbubbles in combination with ultrasound energy as well as applying drugs or therapeutic agents in a cyclic manner using a pulse generator that may be matched in frequency with a patient's blood pulsing.

An ultrasonic mask according to an embodiment comprises: a first substrate; a first wire disposed on the upper surface of the first substrate; a second substrate disposed above the first substrate; a second wire disposed on the lower surface of the second substrate; a piezoelectric member between the first substrate and the second substrate; a first electrode connected to the first wire and disposed on the lower surface of the piezoelectric member; and a second electrode connected to the second wire and disposed on the upper surface of the piezoelectric member, wherein the first wire and the second wire have curvatures (mm) of 5R to 15R, and the piezoelectric member generates an ultrasonic wave having a frequency band of 20 kHz to 1 MHz.

A method for treating central nervous system tumors is a patient comprising: treating the patient intravenously with therapeutic agent including Cremophor EL-free paclitaxel, and disrupting a blood-brain barrier within the brain of the patient by the use of an ultrasound device and intravenous microbubble injection. In other methods, the subject is treated with a therapeutic agent comprising an albumin-bound paclitaxel that crosses the blood brain barrier. In this manner, the disruption of the blood-brain barrier increases the concentration of paclitaxel in the brain as compared to the concentration of paclitaxel in the brain without blood-brain barrier disruption and intravenous microbubble injection.

An apparatus having an implantable ultrasound generating treating device to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, includes several ultrasound generating transducers, which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers each have one or several operating frequencies. The transducers include the group of transducers having several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers. The apparatus is also used to treat brain disorders.

Methods for treating a subject for a parasympathetic bias mediated condition are provided. Aspects of the methods include modulating at least a portion of the subject's autonomic nervous system to increase the sympathetic/parasympathetic activity ratio in a manner effective to treat the subject for the parasympathetic bias mediated condition. In some instances, the subject is known to have parasympathetic bias. Also provided are devices that find use in practicing various embodiments of the methods.

Described herein are compositions featuring TRPA1 polypeptides and polynucleotides, methods for expressing such polypeptides and polynucleotides in a cell type of interest, and methods for inducing the activation of the TRPA1 polypeptide in neurons and other cell types using ultrasound.

Embodiments of the present invention are directed to devices and apparatus for administering collagen modifier compounds to the dermis of skin.

According to some embodiments there is provided a method for controlling a treatment effect on blood vessel tissue during an ultrasonic treatment, the method comprising positioning an ultrasonic transducer device in the blood vessel lumen; controlling a treatment effect by controlling fluid flow, wherein controlling comprises deploying a fluid restrictor at a location relative to the transducer effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. According to some embodiments there is provided an ultrasonic transducer device sized for placement in a body lumen, and comprising a fluid restrictor effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. In some embodiments, the fluid is blood.