Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

Disclosed is a micro-needle including a tip formed using medicine that penetrates into the skin and melts therein; and at least one guide groove each in a stepped shape inward from the outer surface of the tip, and provided to the tip. The micro-needle configured as above may be used to administer a fixed quantity of medicine within a relatively short period of time. Also, since a guide space stepped based on the tip is provided to a base that supports the tip, a large amount of medicine may easily penetrate into the skin.

The production of multicomponent parts (4) which include a functional part (3), in particular a hollow needle, onto which a plastic molding (2), in particular a syringe barrel (2), is molded. In order to be able to convert the injection molding device quickly and conveniently, the device has a changing device (11), by which it is possible optionally to move functional part holders (7, 8, 9), matched to different types of functional parts, and/or a functional part holder (8) and a placeholder element (10) into the use position thereof in front of a mold cavity (6) of the injection mold (5) of the injection molding device (1).

Provided are a transdermal absorption sheet capable of achieving control of the dissolution rate and suppression of diffusion of a drug, and a method of producing the same. A transdermal absorption sheet includes a sheet portion, and a plurality of needle-like protruding portions formed by a plurality of frustum portions arranged on the sheet portion and needle portions arranged on the frustum portions, in which at least one of the needle-like protruding portions has a cavity portion extending from the sheet portion to the frustum portion.

A product having a microneedle array is provided wherein the composition distribution has been adjusted with good accuracy. A droplet-delivery apparatus of a microneedle-array manufacturing apparatus is configured capable of delivering, to each recessed part, droplets of a raw-material liquid in a prescribed amount that is less than the capacity of the recessed part. An aligning apparatus can align the relative position of the droplet-delivery apparatus and a mold such that the droplets from the droplet-delivery apparatus are caused to land in each of the recessed parts. The droplet-delivery apparatus delivers a plurality of the droplets to each of the recessed parts; and the aligning apparatus aligns the relative position of the droplet-delivery apparatus and the mold such that a second droplet lands in each of the recessed parts on the center part side of a first droplet.

Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.

A microneedle including a projection having a through hole formed in the projection in a direction that the projection extends, and a tubular member having an end surface configured to support the projection when the end surface is pressed against a skin and a fluid is supplied through the through hole of the projection to the skin. The projection has a length H along the direction that the projection extends and the supporting surface has an area S such that a ratio of S/H is in a range of from 2.1 to 10.5.

The invention relates to a method for producing a hollow injection-moulded part, in particular a primary packaging means for medical applications by an injection moulding method, comprising the following method steps: a) Providing a first female die tool having a first mould cavity and a mould core formed as a male die tool; b) Introducing a mould core into the first mould cavity so that a first cavity is formed and the mould core extends beyond the mould cavity in the axial direction (X), thereby bringing the mould core into operative contact with the first female die tool and/or with a receiving member; c) Injecting a first plastic material into the first cavity so that a first portion of the injection-moulded part is formed; d) Transferring the first portion of the injection-moulded part to a second cavity; e) Injecting a second plastic material into the second cavity so that a second portion is formed directly on the first portion of the injection-moulded part.

Provided are a production method of a mold, a manufacturing method of a pattern sheet, a production method of an electroform, a production method of a mold using an electroform, and an original. The production method includes: preparing an original having an inclined portion which is formed in an enclosed shape on an outer peripheral portion of a protruding pattern formed at a center portion on a base and gradually increases in thickness from inside toward outside, and a thermoplastic resin sheet; and forming a recessed pattern on the thermoplastic resin sheet by pressing the original which is heated against the thermoplastic resin sheet at a position where a flat surface of the original and a surface of the thermoplastic resin sheet are separated from each other, cooling the original in the state where the original is pressed, and separating the original from the thermoplastic resin sheet.

A novel design of a polymer retention hub created having an innovative feature used to permanently attach a thin wall nozzle core without use of adhesives or ancillary parts to form a conjunct nozzle. Additional polymer in the correct amount is molded into a polymer retention hub in close proximity to a location where a mechanical lock must be formed to join the two components together. The inventive design of the polymer retention hub is configured to produce an enclosed cavity with the strength required for separation of a nozzle core from a standard taper.