Systems and methods for clinical neuronavigation in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a brain stimulation target, including obtaining functional magnetic resonance imaging (fMRI) image data of a patient's brain, where brain imaging data describes neuronal activations within the patient's brain, determining a brain stimulation target by mapping at least one region of interest to the patient's brain, locating functional subregions within the at least one region of interest based on the fMRI image data, determining functional relationships between at least two brain regions of interest, generating parameters for each functional subregion, generating a target quality score for each functional subregion based on the parameters and selecting a brain stimulation target based on its target quality score and the patient's neurological condition.

Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.

In methods for treating a patient, a time varying magnetic field is applied to a patient's body and causes a muscle contraction. The time-varying magnetic field may be monophasic, biphasic, polyphasic and/or static. The method may reduce adipose tissue, improve metabolism, blood and/or lymph circulation. The method may use combinations of treatments to enhance the visual appearance of the patient.

An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone whereby the ferric element force can be adjusted by a force delivery element.

Exemplary magnetic hyperthermia treatment systems and methods involve placing a conducting particle having a diameter of 500 microns within a tumor of a patient; and heating the conducting particle with an oscillating magnetic field. In some cases, the particle has a diameter or dimension with a value within a range of about 20 microns to about 1000 microns. In some cases, particle has a diameter or dimension with a value that is greater than 1000 microns.

A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.

Provided are systems and methods for decalcifying aortic valves and/or other valves, blood vessels, and/or cardiac tissues in a mammalian (e.g., a human) patient (e.g., a patient having or suspected of having calcific aortic valve disease (CAVD)). A transcatheter (aortic) valve decalcification system/method can include applying one or more pulsed magnetic fields to the calcium deposit(s) within a valve or other vessel or tissue within the patient. The system can include a catheter having pulsed magnetic field ribbons disposed therein, and the catheter can be provided to the patient.

A method of targeting magnetic neurostimulation to a patient suffering a mood disorder is initially obtained by creating a brain network model through evaluation of data sensed from the brain of the patient. A determination is made of a brain target location of a first brain region which is based at least partly on a functional connection of the first brain region to a second brain region reflected in the brain network model. A magnetic stimulation signal is transmitted to the brain target location for treatment of the mood disorder of the patient where the magnetic stimulation signal is provided by a transcranial magnetic stimulator.

A static magnetic field generator for treatment of cancer according to an embodiment of the present disclosure includes a static magnetic field generating unit, and a space in which a static magnetic field is formed by the static magnetic field generating unit, wherein the formed static magnetic field has a magnitude range of 0.1 mT to 4 T.

The present invention relates to a treatment device using a magnetic field, which includes a module-type functional cushion that is couplable to a sitting type treatment device generating a pulse magnetic field.

The treatment device using the magnetic field in accordance with an embodiment of the present invention includes: a magnetic field generating coil for generating a magnetic field that is applied to a body of a user; a blower for supplying a fluid for cooling the magnetic field generating coil; a duct for guiding the fluid between the blower and the magnetic field generating coil; and a functional cushion disposed on an area in which the magnetic field is generated by the magnetic field generating coil in a couplable manner and having a shape on which buttocks of the user is seated.