The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.

Various approaches to transmitting an ultrasound beam include creating a 3D tissue replica representing tissue intervening between the ultrasound transducer and a target anatomic region; transmitting a ultrasound beam to the target region; measuring the ultrasound beam traversing the 3D tissue replica and arriving at the target region; and based at least in part on the measured first ultrasound beam, estimating a parameter value associated with one or more of the transducer elements for improving ultrasound beam shaping.

An improved method of treating an appendage of a patient using acoustic shock waves has the steps of: providing an appendage in need of an acoustic shock wave treatment; placing an acoustic shock wave applicator on a surface of the appendage; placing a gaseous filled membrane on an opposite surface of the appendage; activating an acoustic shock wave generator or source to emit acoustic shock waves from an acoustic shock wave applicator; and wherein the acoustic shock wave is transmitted from the acoustic shock wave applicator through the surface sending the emitted acoustic shock waves into the tissue of the appendage and exiting the opposite surface of the appendage to the gaseous filled membrane where a reflection of the acoustic shock wave occurs sending reflected acoustic shock waves back through the appendage.

The present invention generally relates to, inter alia, an ultrasound coupling patch for use with ultrasound transducers, and more particularly to ultrasound coupling patches having a gel capture feature.

Human and animal infections are treated using extracorporeal acoustic pressure shock waves that destroy harmful pathogens as bacteria, viruses, funguses and other micro-organisms to disinfect infected tissue.

A new generation of precision medicine with interfaces processing the predictive feedback over the course of hyperthermia treatment sessions is provided. Implementation of MR-thermometry measurements and real-time spatial imaging can resolve many of the limiting factors currently associated with hyperthermia treatment. More significantly, implementation of artificial intelligence (machine learning) mediated image analysis and database construction can provide the international community with standards for monitoring, and thermal dose calibration.

An ultrasonic irradiation device includes: an ultrasonic transducer for external application of focused ultrasound to a body surface; and a tenderness level meter comprising a pressing element that presses the body surface, a pressing unit that presses the pressing element against the body surface, a load measuring unit that measures a pressing force exerted on the body surface by the pressing element, and a pressure recorder for tenderness perception that records a pressing force at which a pressing action of the pressing element causes pain perception. This makes it possible to measure a tenderness level of an ultrasonic irradiation target area without moving an HIFU transducer from above an affected area.

An ultrasonic irradiation device includes an ultrasonic transducer for external application of HIFU, which is focused ultrasound, to a body surface; and an optical imaging member or camera that takes images of part of the body surface corresponding to an ultrasonic irradiation target area. An irradiation position guide or a marker is located on the body surface, the marker is detected by the camera, and position and irradiation angle of the ultrasonic transducer are controlled based on information about a position of the marker. This makes it possible to direct a therapeutic transducer to a proper irradiation position, and monitor body surface condition during ultrasonic irradiation.

A system applies and senses electrical energy to and from tissue within a patient's body. The system includes a steerable delivery catheter, housing a flexible shaft and an electrical generator disposed on or embedded within the flexible shaft. Electrodes coupled to the shaft self-expand radially from a compressed position to an expanded position once the delivery catheter is withdrawn, thereby contacting a wall of the tissue of the patient's body to conduct electrical or other signals. The system may be inserted into the coronary sinus and tributary vein to provide physiological pacing to the His bundle and left ventricle. Further, the system provides for controlled passive transmission of normal electric impulses from the atria to the His bundle and ventricles without the need for an embedded generator.

A method for heat treating biological tissues includes providing a pulsed energy source having energy parameters selected so as to raise a target temperature to a level to achieve a therapeutic effect, while the average temperature rise of the tissue over a prolonged period of time is maintained at or below a predetermined level so as not to permanently damage the target tissue. Application of the pulsed energy source to the target tissue induces a heat shock response and stimulates heat shock protein activation in the target tissue so as to therapeutically treat the target tissue.