One or more ultrasonic transducers are driven to direct a therapeutic ultrasound signal into tissue. The therapeutic ultrasound signal has a resonant ultrasound frequency to harmonically excite and damage abnormal tissue but not harmonically excite healthy tissue.

Provided is a magnetic resonance imaging (MRI) receiver coil device and methods of manufacture. An MRI receiver coil device comprises a thin-film substrate layer configured in a dome shape and a coil array positioned around a circumference of an exterior surface of the thin-film substrate layer. A thin-film cover layer is positioned over the exterior surface of the thin-film substrate layer such that the coil array is positioned between the thin-film cover layer and the thin-film substrate layer. The MRI receiver coil device further comprises an end ring engaging the thin-film substrate layer and the thin-film cover layer such that a watertight seal is formed around the coil array between the thin-film substrate layer, the thin-film cover layer, and the end ring. The coil array comprises a plurality of coil elements, each coil element comprising a loop of conductive trace material with at least one capacitive segment.

In some aspects, the described systems and methods provide for a device wearable by or attached to a person, comprising at least one annular array transducer configured to provide ultrasound radiation to at least one region of the brain of the person. In some embodiments, the annular array transducer is configured to provide the ultrasound radiation to perform non-invasive neuromodulation or neurostimulation in the at least one region of the brain of the person.

Methods and systems for treating skin, such as stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis or a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth with a conformal selective deposition of ultrasound energy without damaging an intervening tissue. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.

The present disclosure provides an extracorporeal focused ultrasound treatment device for a pelvic disease. The treatment device includes an ultrasonic transducer and a treatment couch. Sound emitting surface of the ultrasonic transducer is a spherical surface having a first notch, a second notch and a third notch, the first notch and the second notch are respectively positioned at two intersections of the spherical surface and a diameter perpendicular to the main great circle, and the third notch connects the first notch with the second notch; a cross-section of the sound emitting surface parallel to the main great circle is in a shape of an arc; and an ultrasonic wave generated by the sound generation unit is focused at a center of the sphere corresponding to the sound emitting surface. The treatment couch is configured for a human body to lie in a lithotomy position.

Systems and methods for non-invasive fat reduction can include targeting a region of interest below a surface of skin, which contains fat and delivering ultrasound energy to the region of interest. The ultrasound energy generates a thermal lesion with said ultrasound energy on a fat cell. The lesion can create an opening in the surface of the fat cell, which allows the draining of a fluid out of the fat cell and through the opening. In addition, by applying ultrasound energy to fat cells to increase the temperature to between 43 degrees and 49 degrees, cell apoptosis can be realized, thereby resulting in reduction of fat.

Techniques are provided for detection and treatment of tumors using ultrasound. An early detection test may be performed on a patient. A location of a tumor may be determined based on the early detection test. Properties of the tumor may be determined based on the early detection test. Moieties may be functionalized based on the properties of the tumor. The moieties maybe introduced into the patient. The location of the tumor may be imaged using ultrasound, magnetic resonance elastography, or computed tomography to generate images of the location of the tumor. A treatment plan based on the images of the location of the tumor may be implemented using ultrasound.

Apparatus and methods for deactivating bronchial nerves extending along the secondary bronchial branches of a mammalian subject to treat asthma and related conditions. An ultrasonic transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the secondary bronchial section to be treated. The ultrasonic transducer emits circumferential ultrasound so as to heat tissues throughout circular impact volume (13) as, for example, at least about 1 cm.sup.3 encompassing the bronchus to a temperature sufficient to inactivate nerve conduction but insufficient to cause rapid ablation or necrosis of the tissues. The treatment can be performed without locating or focusing on individual bronchial nerves. The apparatus and methods utilized for lung tumor ablation.

A method and system of neural stimulation and imaging of nervous system of a subject. The method includes the steps of providing an interface device operable to generate an ultrasonic beam for neuroniodulation and imaging of a targeted neural structure of a subject, implanting the interface device in the subject, and providing and disposing an external coil array over the targeted neural structure of the subject, wherein the external coil array is wirelessly powering and communicating with the interface device.

A device for treatment of a tissue (8) of a living being, including a transducer (4) for emitting a beam of ultrasound waves mounted on a movable treatment head (1), an ultrasonic imaging device (2, 3), optionally an inflatable balloon (5) surrounding the treatment head (1) and containing a coupling fluid, and a control unit for controlling movement of the treatment head (1) and operation of the transducer (4) and the imaging device (2, 3). In order to avoid displacement of tissues (7, 8) during displacement of the treatment head (1) and increase imaging quality, the treatment head (1) is adjustable to at least two of a treatment position (T), a monitoring position (M) and a travel position (S).