An ultrasound transducer array is incorporated in a light-weight, conformable, and wearable patch that may be used to deliver, monitor, and control localized transcranial focused ultrasound (tFUS). The patch may include full-duplex transmit-receive circuitry that may be used for continuous monitoring of transcranial focused ultrasound (tFUS) application. The circuitry may include a circulator. The ultrasound transducer array may be coupled to an aperture interface having irregularly sized or shaped channel conductors to provide a coarse aperture for the array. The coarse aperture may be designed using a method that provides a reduced channel count.

Devices for providing an acoustic wave to a target location include at least one transducer device and at least one beam-forming processor to cause the at least one transducer device to produce a first acoustic wave, the first acoustic wave includes a plurality of pulses having a pulse repetition frequency, where a pulse width of each pulse is in a range of 10 ns to 10 μs and the pulse repetition frequency is in a range of 1 Hz to 50 Hz, receive data associated with a second acoustic wave, wherein the second acoustic wave is a reflection of the first acoustic wave, determine a characteristic of the second acoustic wave, and determine whether to change a beam path of an acoustic wave produced by the at least one transducer device based on the characteristic of the second acoustic wave. Methods and computer program products are also disclosed.

A method can include targeting a region of interest below a surface of skin, which contains fat lobuli and delivering ultrasound energy to the region of interest. The ultrasound energy generates a conformal lesion with said ultrasound energy on a surface of a fat lobuli. The lesion creates an opening in the surface of the fat which allows the draining of a fluid out of the fat lobuli and through the opening. In addition, by applying ultrasound energy to fat cells to increase the temperature to between 43° C. and 49° C. degrees, cell apoptosis can be realized, thereby resulting in reduction of fat.

Methods and systems for modulation and mapping of brain tissue in a subject using an ultrasound assembly are provided. An exemplary method for modulation uses an ultrasound assembly including a housing and an ultrasound transducer joined to the housing. The method includes securing the housing to the head of the subject with the ultrasound transducer aligned with a region of the brain tissue to target the region of the brain tissue for modulating, and providing focused ultrasound at an acoustic pressure to the targeted region using the ultrasound transducer to induce cavitation proximate the targeted region. The method further includes detecting a cavitation signal magnitude from the induced cavitation corresponding to the acoustic pressure and modulating the targeted region.

The present invention relates to an apparatus for treating a pathology, comprising: an ultrasonic generation device (1), a remote control unit (2) to supply electricity to the device (1), electrical connection means (31, 32) between the device (1) and the control unit (2), remarkable in that the control unit (2) is programmed to assess the quality of the acoustic coupling between the ultrasonic device (1) and a tissue to be treated.

An ultrasonic diagnosis and therapy apparatus according to an embodiment may include an ultrasound output unit including a plurality of ultrasound output elements, a circuit board that can be attached and detached through a connecting board connected to the ultrasound output unit to determine a function of the ultrasound output unit, and a control unit configured to control a setting value of each of the plurality of ultrasound output elements, wherein therapy and diagnosis functions are selectively or simultaneously implemented by changing the circuit board. With the ultrasonic diagnosis and therapy apparatus, it is possible to selectively or simultaneously implement the therapy and diagnosis functions by selectively mounting different types of circuit boards that determine the type and function of ultrasound outputted from the ultrasonic transducers.

Systems and methods are provided for performing transcranial diagnostic procedures using a transcranial ultrasound transducer array. The array elements are positioned and oriented such that far field regions respectively associated therewith spatially overlap within the brain of a patient. The array elements may be oriented approximately normal to the skull, permitting efficient coupling of ultrasound energy into the brain. The array elements are controlled to generate ultrasound pulses, where the timing of the pulses is controlled, based on registration between the array elements and volumetric image data, such that ultrasound energy is focused at a target within spatially overlapping far fields of the array elements. The transcranial ultrasound transducer array elements may be positioned and oriented relative to the skull such that their respective ultrasound beams are focused within the skull and diverging with the brain.

Various approaches to focusing an ultrasound transducer includes causing the ultrasound transducer to transmit ultrasound waves to the target region; causing the detection system to indirectly measure the focusing properties; and based at least in part on the indirectly measured focusing properties, adjusting a parameter value associated with at least one of the transducer elements so as to achieve a target treatment power at the target region.

A catheter US transducer container and method of manufacture thereof including a housing, one or more cooling channels oriented longitudinally along a longitudinal axis of the container, a sealing cooling channel cover, one or more PE elements positioned on a floor of the cooling channel, the cooling channel having a trapezoid cross section at any point along the PE element.

A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multichannel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multimodal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data.