The invention provides genetic constructs and recombinant vectors comprising such constructs. The constructs and vectors can be used in gene therapy methods for treating a range of disorders, including glaucoma and deafness, or for promoting nerve regeneration and/or survival.

Disclosed herein are otic formulations and compositions comprising growth factors. These otic formulations and compositions allow for the delivery of the growth factor to the outer, middle, and/or inner ear for the treatment of otic diseases and disorders.

Disclosed herein are otic formulations and compositions comprising growth factors. These otic formulations and compositions allow for the delivery of the growth factor to the outer, middle, and/or inner ear for the treatment of otic diseases and disorders.

Disclosed herein is a controlled drug release system of photoresponsive nanocarriers. Also provided are methods of making the nanocarriers. Also provided are method of using the nanocarriers for the treatment of diseases.

Disclosed herein is a controlled drug release system of photoresponsive nanocarriers. Also provided are methods of making the nanocarriers. Also provided are method of using the nanocarriers for the treatment of diseases.

The invention discloses a Chinese herbal medicine composition for relieving hearing loss and a preparation method and use thereof. The Chinese herbal medicine composition is prepared from at least two of the medicinal and edible raw materials of rhizoma curcumae longae, Dendrobium nobile and fructus Piperis longi, can effectively reduce the content of NO secreted by cells, reduces cell inflammation, and has a good effect of relieving hearing loss induced by LPS. The Chinese herbal medicine composition is not a simple combination of traditional Chinese medicines and has a synergistic effect. The Chinese herbal medicine composition can significantly reduce ABR value, MDA, and glutamic acid of a patient with hearing loss, significantly relieves hearing loss, and can be developed into functional foods and medicines for relieving hearing loss as an active ingredient.

The invention discloses a Chinese herbal medicine composition for relieving hearing loss and a preparation method and use thereof. The Chinese herbal medicine composition is prepared from at least two of the medicinal and edible raw materials of rhizoma curcumae longae, Dendrobium nobile and fructus Piperis longi, can effectively reduce the content of NO secreted by cells, reduces cell inflammation, and has a good effect of relieving hearing loss induced by LPS. The Chinese herbal medicine composition is not a simple combination of traditional Chinese medicines and has a synergistic effect. The Chinese herbal medicine composition can significantly reduce ABR value, MDA, and glutamic acid of a patient with hearing loss, significantly relieves hearing loss, and can be developed into functional foods and medicines for relieving hearing loss as an active ingredient.

The present invention relates to controlled release formulations for treating hearing loss and a method for preparing the same, and more particularly, to controlled release formulations for treating hearing loss prepared by dispersing a steroidal anti-inflammatory agent encapsulated in low molecular weight hyaluronic acid in an aqueous solution of high molecular weight hyaluronic acid and a method for preparing the same.

The present invention relates to controlled release formulations for treating hearing loss and a method for preparing the same, and more particularly, to controlled release formulations for treating hearing loss prepared by dispersing a steroidal anti-inflammatory agent encapsulated in low molecular weight hyaluronic acid in an aqueous solution of high molecular weight hyaluronic acid and a method for preparing the same.

Methods are described for preparing auditory progenitor cells from gingival mesenchymal cells, for uses such as restoring hearing in hearing impaired individuals. In one aspect, a method of treating hearing loss associated with loss of sensory neurons in a human subject is provided, the method comprising the steps of: a. obtaining a population of gingival mesenchymal stem cells (GMSCs); b. optionally expanding the population of GMSCs in vitro; c. encapsulating the population of GMSCs in an elastic three-dimensional scaffold; d. exposing the encapsulated population of GMSCs to a composition comprising one or more growth factors; e. allowing co a sufficient period for the population of GMSCs to differentiate towards auditory progenitor cells; f. optionally retrieving the auditory progenitor cells from the scaffold; and g. introducing the auditory progenitor cells into the inner ear of the subject.